Analysis of Life-threatening ARrhythMias After Acute Coronary Syndrome

NCT07824050 | Recruiting

• 2 other identifiers: nWMO-2026.062project code 24PPS046
• Study Type: observational
• Target: 2,775
• Locations: 1 country
• Sites: 1

Brief Summary

Patients admitted with an acute coronary syndrome (ACS) are at increased risk of malignant cardiac arrhythmias (MA), such as sustained ventricular tachycardia and ventricular fibrillation. Therefore, patients with ST-elevation myocardial infarction (STEMI) are continuously monitored for a minimum of 24 hours after onset symptoms. Longer monitoring is advised in patients at intermediate to high risk of cardiac arrhythmias, however this risk stratification is not evidence based. Hospitalization, particularly in STEMI patients, is advised for a minimum of 48-72 hours. AMI care requires a substantial commitment of bed capacity and staff, resulting in high healthcare costs. In patients who have undergone acute PCI (such as STEMI patients or NSTEMI patients with persistent symptoms), monitoring is primarily aimed at early recognition of MA and signs of persistent or recurrent ischaemia after the intervention. In NSTEMI/UAP patients still awaiting invasive treatment, the emphasis lies on detecting increasing ischaemia in the as-yet untreated coronary vessel, as well as identifying arrhythmias that may arise as a result. The true incidence of MA cannot be precisely established due to heterogeneity in the literature, and moreover varies between patients with ST-elevation myocardial infarction, non-ST-elevation myocardial infarction, and unstable angina pectoris, owing to differences in disease process and care pathway. A better understanding of the current incidence and risk of MA in patients with ACS may contribute to optimizing the monitoring of this patient group, thereby enabling more efficient use of hospital beds and healthcare staff. This prospective quality registry therefore aims to establish the current incidence of MA in ACS patients and to identify potential predictors of MA, while also taking into account other acute complications such as asystole and pulseless electrical activity (PEA).

Conditions

Acute Coronary Syndromes (ACS); Ventricular Tachycardia (VT); Ventricular Fibrillation; Pulseless Electrical Activity; Asystole; Cardiac Arrest (CA); Myocardial Infarction (MI); Non-ST Elevation (NSTEMI) Myocardial Infarction; ST Elevation (STEMI) Myocardial Infarction; Unstable Angina (UA)

Keywords

Incidence; predictors; timing; in-hospital complication; Ventricular Tachycardia; Ventricular Fibrillation; Cardiac Arrest; acute myocardial infarction; acute coronary syndrome

Outcome Measures

Primary Outcomes (1)

• Occurrence of one (or more) malignant arrhythmia(s) (sustained VT or VF) during admission

  Occurrence of one (or more) malignant arrhythmia(s) (sustained VT or VF) during admission, defined as from the moment of physical hospital admission until discharge. (For OHCA patients, the index arrhythmic event preceding hospital admission is not counted as a malignant arrhythmia event; only events occurring from the moment of physical hospital admission onward are included.) (Events of sustained VT or VF occurring during admission of an ACS patient following cardiac surgery, such as CABG, will not be included.)

  During admission

Secondary Outcomes (1)

• Asystole/PEA

  During admission

Study Arms (1)

Patients aged 18 years or older admitted with acute coronary syndrome

Patients aged 18 years or older with acute coronary syndrome (ACS) (ST-elevation myocardial infarction, non-ST-elevation myocardial infarction or unstable angina pectoris) or out-of-hospital cardiac arrest (OHCA) due to ACS, admitted to the emergency cardiac care unit, emergency department, coronary care unit (CCU), intensive care unit (ICU), or cardiology ward.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged 18 years or older with acute coronary syndrome (ACS) (ST-elevation myocardial infarction, non-ST-elevation myocardial infarction, and unstable angina pectoris) or out-of-hospital cardiac arrest (OHCA) due to ACS, admitted to the emergency cardiac care unit, emergency department, coronary care unit (CCU), intensive care unit (ICU), or cardiology ward.

Sponsors & Collaborators

• Catharina Ziekenhuis Eindhoven: lead
• Anna Ziekenhuis Geldrop: collaborator
• St.Jans Gasthuis Weert: collaborator

Study Sites (1)

Catharina Hospital Eindhoven

Eindhoven, North Brabant, 5623 EJ, Netherlands

RECRUITING

MeSH Terms

Conditions

Acute Coronary Syndrome; Tachycardia, Ventricular; Ventricular Fibrillation; Heart Arrest; Myocardial Infarction; Non-ST Elevated Myocardial Infarction; ST Elevation Myocardial Infarction; Angina, Unstable

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Tachycardia; Arrhythmias, Cardiac; Cardiac Conduction System Disease; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Infarction; Ischemia; Necrosis; Angina Pectoris; Chest Pain; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Luuk C Otterspoor, Dr. M.D.

  Catharina Ziekenhuis Eindhoven

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Maud E Kortman, M.D.

CONTACT

040 - 239 91 11; maud.kortman@catharinaziekenhuis.nl

Luuk C Otterspoor, Dr. M.D.

CONTACT

luuk.otterspoor@catharinaziekenhuis.nl

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 7 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr. M.D.

Study Record Dates

• First Submitted: September 11, 2026
• First Posted: September 17, 2026
• Study Start: July 14, 2026
• Primary Completion (Estimated): April 1, 2029
• Study Completion (Estimated): April 1, 2029
• Last Updated: September 17, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

NL (1)