Outcomes of Traumatic Intracranial Hemorrhage in the Elderly

NCT07822724 | Not Yet Recruiting

• 1 other identifier: Traumatic ICH in the Elderly
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

This observational study aims to describe the clinical and radiological characteristics of older adults (aged 65 years and older) who experience traumatic bleeding in the brain, also known as traumatic intracranial hemorrhage. In older patients, even minor head injuries like a simple ground-level fall can lead to significant brain bleeding due to age-related changes, frailty, and the frequent use of blood-thinning medications. The researchers will prospectively monitor geriatric patients admitted to the hospital with a traumatic brain bleed confirmed by a CT scan who are being treated conservatively (without surgery). During the hospital stay, the research team will collect data on the patients' pre-injury health status, current clinical condition, and specific findings on their brain scans. The main goal of the study is to assess the patients' functional recovery and survival by the time they are discharged from the hospital. By observing these cases, the study seeks to identify which specific clinical signs and radiological factors help predict poor or favorable outcomes, ultimately aiming to improve the management and care of older adults with head trauma.

Conditions

Subdural Hematoma; Epidural Hematoma; Traumatic Brain Injury

Keywords

Traumatic Intracranial Hemorrhage; Geriatric; Elderly; Head Trauma; Traumatic Brain Injury; Prognostic Factors

Outcome Measures

Primary Outcomes (1)

• Functional outcome assessed by the Glasgow Outcome Scale-Extended (GOSE)

  Functional outcome will be evaluated using the Glasgow Outcome Scale-Extended (GOSE). The GOSE scale ranges from 1 to 8, where higher scores indicate a better functional outcome. The results are subsequently categorized to define an unfavorable outcome as a GOSE score of 1-4, and a favorable outcome as a GOSE score of 5-8.

  Baseline

Study Arms (1)

Geriatric Patients with Traumatic Intracranial Hemorrhage

This cohort consists of conservatively managed patients aged 65 years or older with a history of blunt or traumatic head injury and CT-confirmed intracranial hemorrhage. Patients who are managed surgically or those with a penetrating brain injury are excluded from this cohort. Because this is an observational study, no experimental interventions are administered to the participants.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of geriatric patients (aged 65 years or older) admitted to the Neurosurgery Department at Assiut University Trauma Hospital. These patients present with a history of blunt or traumatic head injury and have CT-confirmed intracranial hemorrhage. The study focuses specifically on patients who are managed conservatively.

You may qualify if:

• Age 65 years or older.
• History of blunt or traumatic head injury.
• CT-confirmed intracranial hemorrhage.
• Conservatively managed patients.
• Availability of clinical and radiological data.
• Consecutive eligible patients during the defined study period.

You may not qualify if:

• Non-traumatic intracranial hemorrhage.
• Age less than 65 years.
• Incomplete medical records.
• Patients with major pre-existing intracranial pathology that prevents proper analysis.
• Penetrating brain injury.
• Surgically managed patients.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Brain Injuries, Traumatic; Hematoma, Subdural; Hematoma, Epidural, Spinal; Intracranial Hemorrhage, Traumatic; Craniocerebral Trauma

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Trauma, Nervous System; Wounds and Injuries; Intracranial Hemorrhages; Cerebrovascular Disorders; Vascular Diseases; Cardiovascular Diseases; Hematoma; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of Neurosurgery

Study Record Dates

• First Submitted: September 11, 2026
• First Posted: September 16, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): November 1, 2027
• Last Updated: September 16, 2026

Record last verified: 2026-09