Effect of Diode Laser With Dye and Remineralizing Agent on Surface Area of White Spot Lesions by Using Digital Subtraction Radiograph Techniques.

NCT07818655 | Completed DMC

• 1 other identifier: REC-OP-26-01
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The current study was conducted to compare effect of diode laser and perio green dye with reminerlizing agent on surface area white spot lesions by using digital subtraction radiographic techniques.

Conditions

White Spot Lesion of Tooth

Outcome Measures

Primary Outcomes (1)

• surface area measurement white spot lesion (image anylsis)

  The I sensor was a USP-driven digital sensor intended to acquire dental intraoral radiograph images. It was combined with the customized poisoning device supplied with the system. One month after the finalization of the remineralization protocol, another radiographic examination was undertaken. Before subtraction, gamma correction was applied to standardize the density and contrast, and images were obtained and saved as Tagged Image File Format (TIFF) and jpg. used image software for each area (Image J software), and follow-up images were subtracted from the base

  one month

Study Arms (3)

fluoride group

ACTIVE COMPARATOR

The first group (A1B1): The teeth with WSLs were treated with fluoride varinsh with laser application.

Drug: remin pro

The teeth with WSLs were treated with Remin Pro with laser application

ACTIVE COMPARATOR

The teeth with WSLs were treated with Remin Pro with laser application. The second group (A1B2): The contralateral teeth were treated with Remin Pro without laser application.

Drug: remin pro

Xremin pur

ACTIVE COMPARATOR

The teeth with WSLs were treated with Xremin pur with laser application.

Drug: remin pro

Interventions

remin pro DRUG

effect of diode laser and perio green dye with reminerlizing agent on surface area white spot lesions by using digital subtraction radiographic technique

Also known as: xpur remin

The teeth with WSLs were treated with Remin Pro with laser application; Xremin pur; fluoride group

Eligibility Criteria

• Age: 13 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• The patients should be 13e40 years old. The patients should have good oral hygiene, general health, and no systemic disease.

You may not qualify if:

• presence of enamel hypoplasia, dental fluorosis, and carious cavity. These patients have diminished salivary flow or significant tooth wear, and concurrent participation in other clinical trials

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

ALAzaher

Cairo, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Al-Azhar University

Model Details: The first group (A1B1): The teeth with WSLs were treated with Remin Pro with laser application. The second group (A1B2): The contralateral teeth were treated with Remin Pro without laser application.The third group (A2B1): The teeth with WSLs were treated with X Pur Remin with laser application. The fourth group (A2B2): The contralateral teeth were treated with X Pur Remin without laser application. The fifth group (A3B1): The teeth with WSLs were treated with Pro Fluoride Varnish with laser application. The sixth group (A3B2): The contralateral teeth were treated with Pro-Fluoride Varnish without laser.

Study Record Dates

• First Submitted: August 25, 2026
• First Posted: September 14, 2026
• Study Start: May 5, 2022
• Primary Completion: June 5, 2022
• Study Completion: April 20, 2023
• Last Updated: September 14, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)