NCT07815717

Brief Summary

Habitual knuckle cracking is a widespread behavior caused by intra-articular pressure changes and gas release in synovial joints; however, its long-term effects on hand sensorimotor function, joint laxity, and overall biomechanics remain debated, with no structured clinical exercise interventions currently established. This prospective, randomized controlled trial aims to evaluate the effectiveness of a 4-week targeted stabilization exercise program focusing on the radiocarpal, metacarpophalangeal (MCP), and proximal interphalangeal (PIP) joints in young adults aged 18 to 30 years with habitual knuckle cracking. Participants are randomly allocated to either an intervention group receiving twice-weekly stabilization training (8 total sessions) or an un-exercised control group. The study hypothesizes that structured joint stabilization exercises will significantly improve wrist and finger joint position sense (proprioception), enhance upper extremity functional performance, and reduce joint laxity compared to the control group.

Trial Health

65
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Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
42

participants targeted

Target at P25-P50 for not_applicable

Timeline
6mo left

Started Oct 2026

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress2%
Oct 2026Mar 2027

First Submitted

Initial submission to the registry

September 8, 2026

Completed
3 days until next milestone

First Posted

Study publicly available on registry

September 11, 2026

Completed
20 days until next milestone

Study Start

First participant enrolled

October 1, 2026

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 25, 2027

Expected
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

March 28, 2027

Last Updated

September 11, 2026

Status Verified

September 1, 2026

Enrollment Period

5 months

First QC Date

September 8, 2026

Last Update Submit

September 8, 2026

Conditions

Keywords

Joint InstabilityProprioception

Outcome Measures

Primary Outcomes (2)

  • Change from Baseline in Joint Position Sense (JPS) Absolute Error at 4 Weeks

    Baseline and 4 weeks

  • Change from Baseline in Joint Laxity

    Baseline and 4 weeks

Secondary Outcomes (2)

  • Change from Baseline in Upper Extremity Functional Performance using the QuickDASH questionnaire

    Baseline and 4 weeks

  • Change from Baseline in Pain Intensity on Visual Analog Scale (VAS)

    Baseline and 4 weeks

Study Arms (2)

Stabilization Exercise Group

EXPERIMENTAL
Other: Stabilization Exercise Program

Non-Exercise Control Group

NO INTERVENTION

Interventions

A 4-week supervised hand and wrist stabilization exercise program conducted 2 times per week (8 total sessions, 30-45 minutes per session). The protocol targets the radiocarpal (wrist), metacarpophalangeal (MCP), and proximal interphalangeal (PIP) joints. Exercises focus on enhancing joint position sense (proprioception), motor control, isometric and dynamic stabilization, and balanced muscle co-activation around the digits and wrist complex. Progression is individualized based on participant tolerance, maintaining movements within non-painful ranges to prevent joint strain. All sessions are supervised by a physical therapist.

Stabilization Exercise Group

Eligibility Criteria

Age18 Years - 30 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Age between 18 and 30 years,
  • Voluntary agreement to participate and signing the Informed Consent Form following detailed study briefing,
  • Willingness to attend all assessment and intervention sessions.

You may not qualify if:

  • Having an occupation that requires intensive or repetitive use of the upper extremities and fingers,
  • History of prior musculoskeletal injury involving the upper extremity or hand,
  • Presence of physical or sensory impairments (such as visual or auditory deficits) that could interfere with study procedures,
  • History of congenital or acquired orthopedic, neurological, or rheumatological conditions affecting hand or wrist range of motion and function,
  • History of hand or wrist trauma requiring medical, conservative, or surgical management within the past 6 months,
  • Presence of active skin lesions in the intervention region, including burns, cellulitis, vesicles, bullae, psoriasis, open or closed wounds, scar tissue, active infection, or malignancy,
  • Body Mass Index (BMI) ≥30 or a history of morbid obesity.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Joint Instability

Condition Hierarchy (Ancestors)

Joint DiseasesMusculoskeletal Diseases

Central Study Contacts

Borna FARHOOMAND, PT, MSc

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
MSc, Physiotherapist

Study Record Dates

First Submitted

September 8, 2026

First Posted

September 11, 2026

Study Start

October 1, 2026

Primary Completion (Estimated)

February 25, 2027

Study Completion (Estimated)

March 28, 2027

Last Updated

September 11, 2026

Record last verified: 2026-09