Efficacy Evaluation of Microwave Ablation Assisted by Diaphragm Hydrodissection for Hepatocellular Carcinoma and Comparative Analysis With Surgical

NCT07815054 | Not Yet Recruiting

• 1 other identifier: 2026-362
• Study Type: observational
• Target: 200
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to evaluate the local efficacy and safety of hydrodissection-assisted microwave ablation for patients with hepatocellular carcinoma, and to compare its therapeutic outcomes with surgical resection for hepatocellular carcinoma. The main questions it aims to answer are: Is hydrodissection-assisted microwave ablation safe and effective for treating hepatocellular carcinoma? How does the therapeutic effect of hydrodissection-assisted microwave ablation compare with surgical resection for hepatocellular carcinoma? Patients who receive either microwave ablation or surgical resection will Undergo a 2-year follow-up period.

Conditions

Hepatocellular Carcinoma (HCC)

Keywords

Hepatocellular Carcinoma; microwave ablation; Progression-Free Survival; Overall Survival; Diaphragm Hydrodissection

Outcome Measures

Primary Outcomes (1)

• Progression-free survival (PFS)

  the time from initiation of treatment to disease progression or death.

  Up to 2 years after treatment

Secondary Outcomes (1)

• Overall survival (OS)

  Up to 2 years after treatment

Study Arms (2)

Hydrodissection-assisted microwave ablation cohort

Patients with hepatocellular carcinoma receiving hydrodissection-assisted microwave ablation under routine clinical care. No study-specific intervention will be assigned by researchers.

Procedure: Microwave Ablation Assisted by Diaphragm Hydrodissection

Surgical resection cohort

Patients with hepatocellular carcinoma receiving surgical resection under routine clinical care. No study-specific intervention will be assigned by researchers.

Procedure: Surgical Resection

Interventions

Microwave Ablation Assisted by Diaphragm Hydrodissection PROCEDURE

For subphrenic hepatocellular carcinoma treated with microwave ablation, ultrasound-guided injection of normal saline into the diaphragm is performed during ablation to establish a hydrodissection barrier and optimise lesion visualisation.

Hydrodissection-assisted microwave ablation cohort

Surgical Resection PROCEDURE

Patients with subphrenic hepatocellular carcinoma who undergo surgical resection are managed according to clinical diagnostic and therapeutic standards for hepatocellular carcinoma.

Surgical resection cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with hepatocellular carcinoma who underwent diaphragm hydrodissectionassisted microwave ablation or surgical resection at our hospital. All patients were definitively diagnosed with hepatocellular carcinoma based on combined imaging and pathological findings.

Sponsors & Collaborators

• The First Hospital of Jilin University: lead

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases

Central Study Contacts

dezhi Zhang Associate Chief Physician, MD

CONTACT

+8618186876068; dezhi@jlu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Chief Physician，Abdominal Ultrasound Department

Study Record Dates

• First Submitted: September 7, 2026
• First Posted: September 11, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): September 30, 2028
• Study Completion (Estimated): September 30, 2029
• Last Updated: September 11, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share