Impact of Iron Supplementation During Pregnancy

NCT07814378 | Not Yet Recruiting

• 1 other identifier: 2026-2980
• Study Type: observational
• Target: 800
• Locations: 1 country
• Sites: 2

Brief Summary

During pregnancy, iron deficiency is the most common cause of anemia. Anemia is very common during pregnancy and after childbirth. Around half of pregnant women develop anemia, and after delivery, up to 85% of women may be affected. This study looks at whether iron given through a vein (intravenous iron) can improve blood levels and how women feel and function in everyday life before and after giving birth.

Conditions

Anemia; Iron Deficiency Anaemia in Childbirth; Pregnancy

Keywords

Pregancy; Iron deficiency; Anemia

Outcome Measures

Primary Outcomes (1)

• Proportion of patients achieving an increase in hemoglobin concentration of ≥1 g/dL

  Proportion of patients with an increase in hemoglobin concentration of ≥1 g/dL from before the first intravenous iron administration to the last available measurement before delivery

  between iron supplementation and follow-up: 2-4 weeks

Interventions

Iron DRUG

Iron supplementation will be performed according to Hamza et al., Recommendations of the AGG (Obstetrics Working Group, Section for Maternal Diseases) for the Management of Anemia in Pregnancy - Part 1 (Iron Deficiency Anemia) (https://www.thieme-connect.com/products/ejournals/pdf/10.1055/a-2628-7308.pdf)

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: Pregnancy
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

anemia walk-in clinic

You may qualify if:

• Pregnancy

You may not qualify if:

• Thalassemia
• Sickle cell disease
• Aplastic anemia
• Hemochromatosis
• Chronic inflammatory diseases associated with anemia of chronic disease
• Severe renal insufficiency
• Intravenous iron administration within 3 months prior to enrollment

Sponsors & Collaborators

• Johann Wolfgang Goethe University Hospital: lead
• Wuerzburg University Hospital: collaborator

Study Sites (2)

University Hospital Frankfurt, Department for Anaesthesiolgy, Intensive Care, and Pain Therapy

Frankfurt, Germany

Location

University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine

Würzburg, Germany

Location

MeSH Terms

Conditions

Anemia; Iron Deficiencies

Interventions

Iron

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases; Iron Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Metals, Heavy; Elements; Inorganic Chemicals; Transition Elements; Metals

Central Study Contacts

Suma Choorapoikayil, PhD

CONTACT

049-069-6301-83169; Choorapoikayil@med.uni-frankfurt.de

Patrick Meybohm, MD

CONTACT

+49 931 201-30001; meybohm_p@ukw.de

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 4, 2026
• First Posted: September 11, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): August 30, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: September 11, 2026

Record last verified: 2026-09

Locations

DE (2)