Dose-Response and Phase-Specific Effects of Graded Cognitive Load on Functional Mobility in Older Adults: A Kinematic Analysis

NCT07814053 | Not Yet Recruiting

• 1 other identifier: P.T.REC/012/006633
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will be conducted to investigate the effect of dose-response and phase-specific effects of Graded Cognitive Load affect on functional mobility in Older Adults

Conditions

Older People

Keywords

Dose-Response and Phase-Specific; Graded Cognitive Load; Functional Mobility; Older Adults

Outcome Measures

Primary Outcomes (1)

• Timed Up and Go (TUG) Completion Time

  A smartwatch will be used to assess the completion time of the TUG test. The total time required to complete the TUG test under each cognitive load condition will be recorded in seconds and used as the primary measure of functional mobility performance. Increased TUG completion time will indicate deterioration in functional mobility under cognitive interference conditions

  up to one day

Secondary Outcomes (12)

• sit-to-stand phase time

  up to one day

• walking phase time

  up to one day

• turning phase time

  up to one day

• stand-to-sit phase

  up to one day

• gait speed

  up to one day

Study Arms (1)

Dual-Task Cognitive Loading Protocol

EXPERIMENTAL

sixty Participants will perform the time-up-and-go test under four standardized experimental conditions designed to investigate the dose-response and phase-specific effects of graded cognitive load on functional mobility in older adults.

Other: Dual-Task Cognitive Loading Protocol

Interventions

Dual-Task Cognitive Loading Protocol OTHER

Participants will perform the TUG test under four standardized experimental conditions: 1\. Single-Task Condition (Baseline) : Participants will perform TUG test without any additional cognitive task. 2-Low Cognitive Load Condition:Participants will perform the TUG test while simultaneously performing simple backward counting by ones starting from a randomly assigned number between 90 and 100. 3-Moderate Cognitive Load Condition :Participants will perform the TUG test while simultaneously performing serial backward counting by threes starting from a randomly assigned number between 90 and 100. 4-High Cognitive Load Condition:Participants will perform the TUG test while simultaneously performing serial subtraction by sevens (Serial 7s task) starting from a randomly assigned number between 90 and 100.

Dual-Task Cognitive Loading Protocol

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 60 years
• Ability to ambulate independently without assistive devices
• Ability to follow verbal instructions and perform dual-task activities
• Medically stable and capable of participating in functional mobility assessment Cognitive function within normal range, defined as Mini-Mental State Examination (MMSE) score ≥ 24 out of 30, indicating absence of significant cognitive impairment .
• Functionqal independence in basic activities of daily living, defined as Barthel Index score ≥ 90 out of 100
• Body Mass Index (BMI) between 18.5 and 29.9 kg/m², as values ≥ 30 kg/m² (obesity) may adversely affect gait and balance performance.

You may not qualify if:

• Any neurological disease that affects walking or balance, such as stroke or Parkinson's disease
• Any musculoskeletal condition that limits lower-limb movement or affects normal walking patterns
• Severe cognitive impairment defined as Mini-Mental State Examination (MMSE) score \< 24
• Visual, vestibular, or hearing problems that affect safe walking or balance control
• History of lower-limb injury or surgery within the last 6 months
• Serious medical conditions that make participation unsafe, such as unstable cardiac or respiratory disease

Sponsors & Collaborators

• Cairo University: lead

Central Study Contacts

mostafa seliem, master

CONTACT

01554049062; mostafasleim92@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator : mostafa abd-elsamei mohamed

Model Details: Dose-Response and Phase-Specific Effects of Graded Cognitive Load

Study Record Dates

• First Submitted: September 5, 2026
• First Posted: September 10, 2026
• Study Start: September 20, 2026
• Primary Completion (Estimated): February 20, 2027
• Study Completion (Estimated): February 20, 2027
• Last Updated: September 10, 2026

Record last verified: 2026-09