Diode Laser Versus LED for Maxillary Canine Retraction in Orthodontic Patients

NCT07810699 | Recruiting

• 1 other identifier: 26.442.HV
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the effects of diode laser and light-emitting diode (LED) photobiomodulation on maxillary canine retraction during fixed orthodontic treatment. Participants requiring bilateral maxillary first premolar extraction will receive both interventions using a split-mouth design. One maxillary canine will receive diode laser photobiomodulation, while the contralateral maxillary canine will receive LED photobiomodulation. Maxillary canine movement will be evaluated at 4, 8, 12, and 16 weeks during retraction to compare the amount and rate of tooth movement between the two interventions. Pain associated with orthodontic tooth movement will also be assessed. Pulp oxygen saturation (SpO₂) of the maxillary canines will be measured to evaluate changes in pulpal oxygenation during orthodontic canine retraction. SpO₂ will be assessed at baseline and at predefined follow-up time points, including 20 minutes, 24 hours, 7 days, and 4 weeks. Changes in SpO₂ will be compared between the diode laser and LED sides. Cone-beam computed tomography (CBCT) will be used to evaluate changes in maxillary canine root length and alveolar bone dimensions before and after canine retraction. The study is expected to determine whether diode laser and LED photobiomodulation differ in their effects on orthodontic canine retraction, pulpal oxygenation, pain, and associated dental and alveolar bone changes.

Conditions

Malocclusion Class I

Keywords

Orthodontic tooth movement; Photobiomodulation; Diode laser; Light-emitting diode; SpO₂

Outcome Measures

Primary Outcomes (1)

• Amount of Maxillary Canine Retraction

  The amount of maxillary canine retraction will be measured in millimeters using digital intraoral scans. Canine movement will be assessed by comparing the position of the maxillary canine at baseline and at each follow-up time point. The amount of retraction on the diode laser side will be compared with that on the contralateral LED side within the same participant.

  Baseline, 4 weeks, 8 weeks, 12 weeks, and 16 weeks

Secondary Outcomes (4)

• Pain Intensity Following Orthodontic Canine Retraction

  1 day, 3 days, and 7 days after photobiomodulation

• Change in Maxillary Canine Root Length

  Baseline and 16 weeks

• Change in Alveolar Bone Dimensions Around the Maxillary Canine

  Baseline and 16 weeks

• Change in Pulp Oxygen Saturation of the Maxillary Canine

  Baseline, 20 minutes, 24 hours, 7 days, and 4 weeks after initiation of canine retraction.

Study Arms (2)

Diode Laser

EXPERIMENTAL

The maxillary canine allocated to the diode laser side will receive diode laser photobiomodulation during orthodontic canine retraction. Photobiomodulation will be applied according to the study protocol and repeated at 4-week intervals during the 16-week observation period.

Device: Diode Laser Photobiomodulation

LED

ACTIVE COMPARATOR

The contralateral maxillary canine allocated to the LED side will receive light-emitting diode (LED) photobiomodulation during orthodontic canine retraction. Photobiomodulation will be applied according to the study protocol and repeated at 4-week intervals during the 16-week observation period.

Device: LED Photobiomodulation

Interventions

LED Photobiomodulation DEVICE

The contralateral maxillary canine will receive light-emitting diode (LED) photobiomodulation during orthodontic canine retraction. LED irradiation will be applied at 12 points around the canine root, including six points on the buccal side and six points on the palatal side. The LED will be applied for 5 seconds at each point, with an energy density of 6 J/cm² and a wavelength range of 430-480 nm. The intervention will be repeated at 4-week intervals during the 16-week canine retraction period.

LED

Diode Laser Photobiomodulation DEVICE

Diode laser photobiomodulation at a wavelength of 810 nm will be applied to the maxillary canine during orthodontic retraction. Irradiation will be delivered at 12 points around the canine root, including six points on the buccal side and six points on the palatal side. The root area will be divided into cervical, middle, and apical regions. The laser will be applied for 10 seconds per region, delivering 1 J per region and a total energy of 6 J per tooth. The energy density will be 5.1 J/cm². The intervention will be repeated at 4-week intervals during the 16-week canine retraction period.

Diode Laser

Eligibility Criteria

• Age: 15 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Patients with complete permanent dentition and cervical vertebral maturation at CS5 or CS6 according to the Baccetti classification.
• Angle Class I malocclusion.
• Indication for fixed orthodontic treatment requiring bilateral extraction of the maxillary first premolars.
• Similar position, morphology, and dimensions of the maxillary canines on both sides.
• No previous orthodontic treatment.
• Willingness to participate in the study and provision of informed consent.

You may not qualify if:

• Patients with bleeding or coagulation disorders, diabetes mellitus, bone diseases, or periodontal diseases.
• Use of medications that may affect orthodontic tooth movement or coagulation, including aspirin, heparin, warfarin, nonsteroidal anti-inflammatory drugs, or glucocorticoids.
• History of maxillofacial trauma or craniofacial anomalies.
• Smoking.
• Pregnancy.
• Requirement for extraction of teeth other than the first premolars.

Sponsors & Collaborators

• Can Tho University of Medicine and Pharmacy: lead

Study Sites (1)

Saigon Dental Clinic - Dr. Lam

Can Tho, CAN THO, Vietnam

RECRUITING

Central Study Contacts

Lam Le

CONTACT

+84 918130809; lenguyenlam@ctump.edu.vn

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 2, 2026
• First Posted: September 9, 2026
• Study Start: January 3, 2026
• Primary Completion (Estimated): July 1, 2027
• Study Completion (Estimated): July 1, 2027
• Last Updated: September 9, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

VN (1)