Hair Regrowth Following Partial Thickness Removal of SSCIS

NCT07809191 | Not Yet Recruiting

• 1 other identifier: 26-044
• Study Type: interventional
• Target: 15
• Locations: 0 countries
• Sites: N/A

Brief Summary

Participants are being approached to participate in this study because they are undergoing surgery for a skin cancer known as squamous cell carcinoma in situ (SCCIS) on the scalp. Standard surgical techniques may remove deeper structures that contain hair follicles, which can result in permanent hair loss. This study evaluates whether a modified surgical technique, known as partial thickness excision, can preserve hair growth and improve cosmetic outcomes. Participation involves minimal risk beyond the standard risks of Mohs surgery. If patients choose to participate, their surgery will be performed using this technique, and photographs will be taken over time to evaluate hair regrowth and healing.

Conditions

Squamous Cell Carcinoma (Skin); Squamous Cell Carcinoma in Situ; Alopecia

Keywords

mohs micrographic surgery; partial thickness excision

Outcome Measures

Primary Outcomes (1)

• Hair Growth measured clinically by hair density percentage compared to baseline photo

  To evaluate hair growth following partial thickness excision of SCCIS at 3 and 6 months post-procedure.

  3 and 6 months post-procedure.

Secondary Outcomes (3)

• Clearance of SCCIS measured by Mohs surgeons' interpretation of margins on surgical slides.

  Immediately following the final Mohs stage during the index procedure

• Patient Satisfaction measured via patient satisfaction questionnaire

  3 and 6 months post-procedure

• Complications

  2 weeks post-procedure, 3 months post-procedure, and 6 months post-procedure

Study Arms (1)

Partial Thickness Excision

EXPERIMENTAL

Participants will receive excision of their squamous cell carcinoma in situ of the scalp via partial thickness excision (removal of epidermal and superficial dermal tissue) in an effort to preserve hair follicles and hair growth potential.

Procedure: Partial Thickness Excision

Interventions

Partial Thickness Excision PROCEDURE

Participants will receive excision of their squamous cell carcinoma in situ of the scalp via partial thickness excision (removal of epidermal and superficial dermal tissue) in an effort to preserve hair follicles and hair growth potential.

Partial Thickness Excision

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults ≥ 18 years old
• Histologically confirmed SCCIS
• Lesions located in the hair-bearing scalp
• Ability to provide informed consent

You may not qualify if:

• Invasive, poorly differentiated, or high-risk SCC features (e.g., perineural invasion)
• Recurrent SCC at the same site
• Prior radiation therapy to the scalp
• Scarring alopecia or active inflammatory scalp disease at the treatment site
• Immunosuppression that, in the investigator's judgement, increases oncologic risk
• Use of topical minoxidil, oral minoxidil, finasteride, spironolactone, or other hair-growth promoting agents

Sponsors & Collaborators

• The Cooper Health System: lead

MeSH Terms

Conditions

Carcinoma, Squamous Cell; Squamous Intraepithelial Lesions; Alopecia

Condition Hierarchy (Ancestors)

Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Squamous Cell; Morphological and Microscopic Findings; Pathological Conditions, Signs and Symptoms; Hypotrichosis; Hair Diseases; Skin Diseases; Skin and Connective Tissue Diseases; Pathological Conditions, Anatomical

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: August 4, 2026
• First Posted: September 9, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): July 17, 2027
• Study Completion (Estimated): July 17, 2028
• Last Updated: September 9, 2026

Record last verified: 2026-07