An Open-Label, Multicenter, Phase IB/II Clinical Study of HRS-7172 in Combination With Antitumor Therapy in Participants With Solid Tumors

NCT07806058 | Not Yet Recruiting Phase 1

• 1 other identifier: HRS-7172-201
• Study Type: interventional
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

This is a Phase IB/II clinical trial designed to evaluate HRS-7172 in combination with antitumor drugs in participants with advanced pancreatic cancer harboring RAS mutations or amplifications. The study process includes a screening period (from signed informed consent to first dose), a treatment period (from first dose to last dose), and a follow-up period (safety and survival follow-up after last dose). A Safety Monitoring Committee (SMC), composed of the principal investigator and sponsor representatives, will be established during the study to review the safety and efficacy data generated. The SMC will make decisions on study-related matters, including but not limited to combination regimen dose exploration, combination regimen selection, efficacy expansion cohort selection, expansion initiation timing, and recommended dose for expansion (RDE). This study aims to evaluate the safety, tolerability, and efficacy of HRS-7172 in combination with other antitumor therapies in participants with advanced or metastatic pancreatic cancer harboring RAS mutations or amplifications.

Conditions

Pancreatic Cancer

Outcome Measures

Primary Outcomes (3)

• RDE in advanced pancreatic cancer with RAS mutation or amplification

  From the signing of the informed consent form to the end of the safety follow-up. Estimated to be 2 years

• Incidence and severity of adverse events (AEs) (per NCI-CTCAE V6.0 criteria)

  From the signing of the informed consent form to the end of the safety follow-up. Estimated to be 2 years

• ORR assessed by the investigator

  From the signing of the informed consent form to the end of the safety follow-up. Estimated to be 2 years

Secondary Outcomes (7)

• Objective Response Rate (ORR) as assessed by the investigator

  From signing of the informed consent form to the end of the safety follow-up. Estimated to be 2 years

• Disease Control Rate (DCR) as assessed by the investigator

  From signing of the informed consent form to the end of the safety follow-up. Estimated to be 2 years

• Duration of Response (DoR) as assessed by the investigator

  From signing of the informed consent form to the end of the safety follow-up. Estimated to be 2 years

• Progression-Free Survival (PFS) as assessed by the investigator

  From signing of the informed consent form to the end of the safety follow-up. Estimated to be 2 years

• Overall Survival (OS)

  From signing of the informed consent form to the end of the safety follow-up. Estimated to be 2 years

Study Arms (8)

Treatment group A-low dose: HRS-7172 + AG + SHR-1316

EXPERIMENTAL

Drug: HRS-7172 + AG + SHR-1316

Treatment group A-high dose: HRS-7172 + AG + SHR-1316

EXPERIMENTAL

Drug: HRS-7172 + AG + SHR-1316;

Treatment group A1: HRS-7172 + AG

EXPERIMENTAL

Drug: HRS-7172 + AG;

Treatment group A2: HRS-7172 + AG + SHR-1316

EXPERIMENTAL

Drug: HRS-7172 + AG + SHR-1316;

Treatment group B-low dose: HRS-717 + HRS-4642+SHR-1316

EXPERIMENTAL

Drug: HRS-717 + HRS-4642+SHR-1316;

Treatment group B-high dose: HRS-717 + HRS-4642+SHR-1316

EXPERIMENTAL

Drug: HRS-717 + HRS-4642+SHR-1316;

Treatment group B1: HRS-717 + HRS-4642

EXPERIMENTAL

Drug: HRS-717 + HRS-4642;

Treatment group B2: HRS-717 + HRS-4642+SHR-1316

EXPERIMENTAL

Drug: HRS-717 + HRS-4642+SHR-1316;

Interventions

HRS-7172 + AG; DRUG

HRS-7172 + AG; low/high dose

Treatment group A1: HRS-7172 + AG

HRS-7172 + AG + SHR-1316; DRUG

HRS-7172 + AG + SHR-1316; high dose

Treatment group A-high dose: HRS-7172 + AG + SHR-1316

HRS-717 + HRS-4642+SHR-1316; DRUG

HRS-717 + HRS-4642+SHR-1316; low dose

Treatment group B-low dose: HRS-717 + HRS-4642+SHR-1316

HRS-717 + HRS-4642; DRUG

HRS-717 + HRS-4642; low/high dose

Treatment group B1: HRS-717 + HRS-4642

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Capable of giving informed consent, have signed and dated the IRB/EC-approved informed consent form, and are willing and able to comply with scheduled visits, examination requirements, and other study procedures.
• Aged 18 to 70 years (inclusive) at the time of signing the informed consent form, regardless of sex.
• ECOG performance status of 0 or 1.
• Locally advanced or metastatic pancreatic cancer confirmed by histology and cytology, with RAS mutation/amplification detected by tissue or blood genetic testing.
• Participants who have received at most one prior line of standard therapy.
• Life expectancy ≥ 12 weeks.
• At least one measurable lesion as defined by RECIST v1.1.
• Participants must provide formalin-fixed, paraffin-embedded tumor tissue blocks or unstained tumor specimens.
• Adequate organ and bone marrow function.
• Female participants of childbearing potential must agree to use contraception and refrain from donating eggs from the time of signing the informed consent form until 6 months after the last dose of the study drug; serum human chorionic gonadotropin (HCG) test must be negative within 7 days prior to the first dose, and must not be breastfeeding. Male participants whose partners are women of childbearing potential must agree to use contraception and refrain from donating sperm from the time of signing the informed consent form until 5 months after the last dose of the study drug.

You may not qualify if:

• Participants with untreated or active central nervous system (CNS) metastases or leptomeningeal metastases (including history thereof).
• Concurrent other malignancies ≤ 3 years prior to the first dose, with the following exceptions: adequately treated carcinoma in situ of the cervix, basal cell or squamous cell skin carcinoma, localized prostate cancer after radical surgery, ductal carcinoma in situ after radical surgery, and papillary thyroid carcinoma after radical surgery (hormonal therapy for non-metastatic prostate cancer or breast cancer is permitted).
• Participants with uncontrollable tumor-related pain as determined by the investigator. Participants requiring analgesic therapy must have a stable analgesic regimen at study entry; symptomatic lesions eligible for palliative radiotherapy should have completed treatment before study entry.
• Severe cardiovascular or cerebrovascular diseases.
• Gastrointestinal diseases affecting drug administration/absorption, including but not limited to dysphagia, malabsorption syndrome, refractory nausea, vomiting, diarrhea, Crohn's disease, and ulcerative colitis; intestinal obstruction or related symptoms and signs within 6 months prior to the start of study treatment, unless surgically treated with complete resolution; clinically significant acute or chronic pancreatitis; other gastrointestinal conditions deemed unsuitable for enrollment by the investigator.
• Clinically significant bleeding events (including but not limited to hematemesis, melena, hematochezia, etc., excluding hemorrhoidal bleeding or isolated fecal occult blood positive) within 6 months prior to the start of study treatment, or a definite bleeding tendency, high bleeding risk, coagulation disorder, or thrombotic tendency.
• Clinically symptomatic moderate or severe ascites (i.e., requiring therapeutic paracentesis or drainage within 2 weeks prior to the start of study treatment; participants with only small-volume ascites on imaging without clinical symptoms may be enrolled); uncontrolled or moderate or greater pleural effusion or pericardial effusion.
• Severe infection within 4 weeks prior to the start of study treatment, including but not limited to bacteremia, severe pneumonia, or other serious infectious complications requiring hospitalization; active infection of CTCAE ≥ Grade 2 requiring systemic antibiotic therapy within 2 weeks prior to the first dose; excluding participants receiving prophylactic antibiotic therapy (e.g., for prevention of urinary tract infection).
• History of immunodeficiency, including HIV positive; active hepatitis B (positive HBsAg at screening with HBV DNA quantification ≥ 1000 copies/mL or 500 IU/mL) or hepatitis C (anti-HCV positive with HCV RNA positive).
• Active pulmonary tuberculosis infection within 1 year prior to enrollment as determined by history or imaging, or a history of active pulmonary tuberculosis infection more than 1 year ago without standard treatment.
• Adverse reactions from prior antitumor therapy that have not recovered to CTCAE ≤ Grade 1 (except alopecia, Grade 2 peripheral neurotoxicity, laboratory values meeting enrollment criteria, or other conditions determined by the investigator not to affect study drug treatment).
• Systemic antitumor therapy (including chemotherapy, biological therapy, targeted therapy, immunotherapy, radical radiotherapy, etc.) within 4 weeks prior to the start of study treatment.
• Major organ surgery (excluding needle biopsy), significant trauma within 4 weeks prior to the first dose of study drug, or planned elective surgery during the study; minor traumatic procedures (biopsy, endoscopy, and drainage) within 7 days prior to the first dose.
• Receipt of live attenuated vaccines within 28 days prior to the first dose of study drug, or anticipated need for live attenuated vaccines during the study treatment period.
• Pregnant or lactating women, or female participants planning to become pregnant during the study period or within 7 months after the last dose of study drug.

Sponsors & Collaborators

• Jiangsu HengRui Medicine Co., Ltd.: lead

Study Sites (1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, 200032, China

Location

MeSH Terms

Conditions

Pancreatic Neoplasms

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases

Central Study Contacts

Ning/Yirong Dou/Cheng, PhD/MD

CONTACT

0518-82342973; ning.dou@hengrui.com/yirong.cheng.yc58@hengrui.com

Mengbo/Pengjun Zhao/Xiang

CONTACT

0518-82342973; mengbo.zhao@hengrui.com/pengjun.xiang.px6@hengrui.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: The study will be divided into two parts based on participants' RAS mutation types: Part A and Part B. Both Part A and Part B include a Phase IB stage and a Phase II stage. In the Phase IB stage, dose escalation will be conducted with two pre-specified dose levels. After completing the Phase IB dose escalation stage, the study will proceed to the Phase II efficacy expansion stage, with participants randomized 1:1 into A1/A2 or B1/B2.

Study Record Dates

• First Submitted: September 2, 2026
• First Posted: September 8, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2029
• Last Updated: September 8, 2026

Record last verified: 2026-09

Locations

CN (1)