The Effectiveness of Strength Training and Self-management in Reducing Symptoms for Individuals With Knee Osteoarthritis

NCT07804212 | Not Yet Recruiting DMC

• 1 other identifier: PTVGH26-CT4-04
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the effectiveness of an intervention combining strength training and self-management education in improving symptoms, sleep quality, emotional well-being, and quality of life in patients with knee osteoarthritis. This study employs a quasi-experimental design. Participants diagnosed with knee osteoarthritis were recruited from the outpatient orthopedics and rehabilitation departments of a public regional teaching hospital in southern Taiwan. They were randomly assigned to either an experimental group (n = 50) or a control group (n = 50). Due to the nature of the intervention, blinding was not feasible, and participants were aware of their group assignment. The experimental group also participated in a home-based strength training program, while the control group received conventional osteoarthritis routine care. Data were collected at baseline, one month, and three months post-intervention during follow-up appointments.

Conditions

Osteoarthritis

Keywords

strength training; self-management; knee osteoarthritis

Outcome Measures

Primary Outcomes (4)

• Emotional well-being measured by the HADS

  The HADS consists of anxiety and depression subscales, each with seven items and a maximum score of 21; higher scores indicate greater symptom severity.

  Baseline, 1 month, and 2 months

• Sleep quality measured by the PSQ

  The PSQI comprises seven components: subjective sleep quality, sleep latency, sleep duration, sleep efficiency, sleep disturbance, use of sleep medication, and daytime dysfunction. Scores range from 0 to 21, with higher scores indicating poorer sleep quality.

  Baseline, 1 month, and 2 months

• Quality of life measured by the EQ-5D-3L

  EQ-5D-3L comprises two components: (1) the EQ-5D health index. A maximum total score of 15; lower scores indicate better health-related quality of life. (2) EQ-VAS uses a visual analog scale with a maximum score of 100.

  Baseline, 1 month, and 2 months

• OA symptoms measured by the WOMAC

  WOMAC: The Mandarin Chinese version uses a 100-mm visual analog scale, with ends representing opposite symptoms like "no pain" to "very painful," "no stiffness" to "very stiff," and "no difficulty" to "very difficult." Scores range from 0 to 100 per question, with pain up to 500, stiffness up to 200, and activity up to 1700 points.

  Baseline, 1 month, and 2 months

Study Arms (2)

Strength Training Group

EXPERIMENTAL

A structured home-based strength training program consisting of knee endurance exercises, sit-to-stand transitions, walking, and range-of-motion (ROM) exercises. The intervention is performed three times per week for 8 weeks. To ensure exercise fidelity and safety, the 'teach-back' method is utilized during initial instruction, and participants maintain a daily exercise log to monitor compliance.

Other: Strength Training

conventional osteoarthritis routine care

OTHER

The group will receive conventional osteoarthritis routine care. Follow-up assessments will be conducted during the second clinic visit (1 month post-enrollment) and the third clinic visit (2 months post-enrollment).

Other: Strength Training

Interventions

Strength Training OTHER

A structured home-based strength training program consisting of knee endurance exercises, sit-to-stand transitions, walking, and range-of-motion (ROM) exercises. The intervention is performed three times per week for 8 weeks. To ensure exercise fidelity and safety, the 'teach-back' method is utilized during initial instruction, and participants maintain a daily exercise log to monitor compliance.

Strength Training Group; conventional osteoarthritis routine care

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 45 or older
• Diagnosed with symptomatic knee osteoarthritis by a physician
• Normal hearing and able to communicate effectively

You may not qualify if:

• Severe inflammatory arthritis
• Pending or previous unilateral or bilateral total knee replacement
• Contraindications to exercise therapy
• Received physical therapy or knee injections in the past month
• Psychiatric or cognitive impairments

Sponsors & Collaborators

• Pingtung Veterans General Hospital: lead

Study Sites (1)

Fooyin University

Kaohsiung City, Taiwan (r.o.c.), 831301, Taiwan

Location

MeSH Terms

Conditions

Osteoarthritis; Osteoarthritis, Knee

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Central Study Contacts

Ching-Ju Chen, PhD

CONTACT

+886923911285; FT096@fy.edu.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 10, 2026
• First Posted: September 4, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): May 11, 2027
• Study Completion (Estimated): May 11, 2027
• Last Updated: September 24, 2026

Record last verified: 2026-05

Data Sharing

• IPD Sharing: Will share

Locations

TW (1)