Hyperspectral Imaging in Robot-Assisted Partial Nephrectomy

NCT07803315 | Recruiting

• 1 other identifier: RAPN-HSI-059/25-ck
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this prospective observational study is to learn about the use of a novel imaging technique called hyperspectral imaging in adult participants who are having surgery for removing a tumor from their kidney. Hyperspectral imaging works by shining light on a structure (in this case, the kidney tissue with the tumor) and capturing how it reflects hundreds of very narrow color bands, including ones the human eye can't see. These patterns depend on the composition of the tissue and for example how well blood is flowing through the tissue. By studying these patterns, the investigators want to understand if this technique can be helpful for the surgery where only the part of the kidney with the tumor is removed. The main questions it aims to answer are:

• Can hyperspectral imaging show the areas of blood flow in the kidney during surgery?
• Is there a connection between the detected patterns of light and the type of kidney tumor? The imaging will happen during the already planned surgery and the participant does not need to undergo any additional tests.

Conditions

Kidney Neoplasm; Renal Mass up to 7cm

Keywords

Kidney Tumor; Partial Nephrectomy; Robotic Surgical Procedures; Minimally Invasive Surgical Procedures; Optical Imaging

Outcome Measures

Primary Outcomes (2)

• Correlation of hyperspectral imaging (HSI) data with clamping technique during robot-assisted partial nephrectomy (RAPN)

  day of surgery

• Correlation of HSI data with histopathological report

  day of surgery

Secondary Outcomes (2)

• Correlation of HSI data with demographic parameters

  day of surgery

• Correlation of HSI data and respective clamping technique with postoperative kidney function

  from the day of surgery until discharge (up to 6 days)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Eligible participants for the trial will be selected from all patients referred to the Department of Urology at the University Hospital Leipzig for undergoing partial nephrectomy.

You may qualify if:

• Patients with a kidney tumor ≤7cm
• planned robot-assisted partial nephrectomy
• age ≥ 18 years

You may not qualify if:

• patients with a previous surgery on the affected kidney
• patients with a fully intrarenal/endophytic tumor without an exophytic component
• previous malignancy with ongoing or planned nephrotoxic chemotherapy
• current immunosuppression (e.g., organ transplantation, leukemia)
• pregnancy, lactation, or women who wish to have children
• inability to give informed consent

Sponsors & Collaborators

• University of Leipzig: lead

Study Sites (1)

University Hospital Leipzig

Leipzig, 04103, Germany

RECRUITING

MeSH Terms

Conditions

Kidney Neoplasms; Carcinoma, Renal Cell

Condition Hierarchy (Ancestors)

Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type

Central Study Contacts

Jens-Uwe Stolzenburg, Professor Dr.

CONTACT

+49 3419717600; jens-uwe.stolzenburg@medizin.uni-leipzig.de

Doreen Trebst, Dr.

CONTACT

+49 3419717610; doreen.trebst@medizin.uni-leipzig.de

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr. Jens-Uwe Stolzenburg

Study Record Dates

• First Submitted: August 14, 2025
• First Posted: September 3, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): August 1, 2028
• Study Completion (Estimated): August 1, 2028
• Last Updated: September 3, 2026

Record last verified: 2026-09

Locations

DE (1)