Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Healthy Individuals H

NCT07801950 | Not Yet Recruiting

• 1 other identifier: Ec_HAvsLA_sleep_H
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in healthy individuals, who live permanently \>2600m.

Conditions

Healthy; Healthy Adult; High Altitude Effects; High Altitude; Polygraphy; Sleep; Sleep Disordered Breathing (SDB)

Keywords

Health; High Altitude; Polygraphy; Sleep; Sleep disordered breathing

Outcome Measures

Primary Outcomes (1)

• Mean nocturnal SpO2 after 7 days at sea level

  Difference/change in mean nocturnal SpO2 between 2850m and Night 7 at sea level in healthy individuals

  From high altitude (2850m) to night 7 at sea level

Secondary Outcomes (19)

• Time spent with low SpO2 after 7 days at sea level

  From high altitude (2850m) to night 7 at sea level

• Apnoea-Hypopnoea-Index AHI after 7 days at sea level

  From high altitude (2850m) to night 7 at sea level

• Oxygen-Desaturation-Index ODI after 7 days at sea level

  From high altitude (2850m) to night 7 at sea level

• Nocturnal cardiovascular autonomic control after 7 days at sea level

  From high altitude (2850m) to night 7 at sea level

• Acclimatization-Effect of mean nocturnal SpO2 at sea level

  From Night 1 to Night 7 at sea level

Study Arms (1)

Sleep-parameters at 2850m and at sea level

EXPERIMENTAL

Assessment of sleep-parameters by polygraphy in healthy individuals at 2850m (pre-descent and after re-ascent) and at sea level in between

Behavioral: Descent from 2850m to sea level and re-ascent back to 2850m

Interventions

Descent from 2850m to sea level and re-ascent back to 2850m BEHAVIORAL

Descent from 2850m to sea level with a stay for 7 days and re-ascent back to 2850m

Sleep-parameters at 2850m and at sea level

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18-80 years and of all genders
• Permanent residence \> 2600 m
• healthy: no self-perceived cardiopulmonary disease limiting daily activities
• written informed consent to participate in the study

You may not qualify if:

• Age \<18 years or \>80 years
• Participants who cannot follow the study investigations
• Participants permanently living \< 2600m.
• Participants who traveled and stayed overnight at altitudes \<2000 m in the past 4 weeks.
• any self-perceived cardiopulmonary disease limiting daily activities

Sponsors & Collaborators

• Silvia Ulrich Somaini: lead

Study Sites (1)

University Hospital of Zurich

Zurich, 8091, Switzerland

Location

MeSH Terms

Conditions

Altitude Sickness; Sleep Apnea Syndromes

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Apnea; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Study Officials

• Silvia Ulrich

  University Hospital Zurich, Departement of Pulmonology

  PRINCIPAL INVESTIGATOR

• Rodrigo Hoyos

  Hospital Carlos Andrade Marin of Quito, Ecuador

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Silvia Ulrich, Prof. Dr. med.

CONTACT

+41442552220; silvia.ulrich@usz.ch

Michael Furian, Prof. Dr. sc. ETH

CONTACT

+41442552220

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Prof. Dr. med.

Model Details: Healthy individuals living permanently \> 2600m around Quito (Ecuador) will be assessed at 2850m, after relocation to sea level for 7 days and after re-ascent

Study Record Dates

• First Submitted: August 17, 2026
• First Posted: September 3, 2026
• Study Start: September 25, 2026
• Primary Completion: October 4, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: September 3, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will share

Locations

CH (1)