Factors Affecting Postoperative Recovery From Common Bile Duct Cysts in Children: A Multicenter Retrospective Analysis Based on Perioperative Clinical Characteristics

NCT07800169 | Completed

• 2 other identifiers: WuhanChildrensH2025FEYJS005
• Study Type: observational
• Target: 550
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective study aims to systematically analyze the factors influencing short-term rehabilitation and liver function recovery after radical surgery for pediatric common bile duct cysts, identify independent risk factors, construct a risk prediction model, and provide an evidence-based basis for optimizing perioperative management.

Conditions

Choledochal Cyst Resection

Keywords

choledochal cyst; postoperative flatus; Roux-en-Y hepaticojejunostomy; pediatric surgery

Outcome Measures

Primary Outcomes (3)

• First flatus time (hours)

  From the date of surgery until the date of first flatus, assessed up to 7 days postoperatively.

• First defecation time

  From the date of surgery until the date of first defecation, assessed up to 7 days postoperatively.

• Postoperative length of hospital stay (days)

  From the date of surgery until the date of hospital discharge, assessed up to 3 months postoperatively.

Eligibility Criteria

• Age: 1 Week - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

This study enrolled patients admitted between 2017 and 2025 to the Department of Hepatobiliary Surgery at Wuhan Children's Hospital, Anhui Provincial Children's Hospital, Shanxi Provincial Children's Hospital, Tianjin Children's Hospital, or the Affiliated Hospital of Zunyi Medical University. All patients were scheduled to receive either laparoscopic cholecystectomy and choledochal cyst excision, end-to-side jejunojejunal Y anastomosis and hepaticojejunostomy, or robot-assisted laparoscopic cholecystectomy and choledochal cyst excision, end-to-side jejunojejunal Y anastomosis and hepaticojejunostomy. The target population was patients aged 0-16 years who were definitively diagnosed with choledochal cyst via preoperative pathology or imaging examination, and met the indications for elective surgery. All enrolled patients must have complete perioperative clinical data, and be able to cooperate with postoperative follow-up observation until discharge.

You may qualify if:

• \) Age between 0-16 years, meeting the age-based classification criteria for pediatric patients; 2) Diagnosis of common bile duct cyst confirmed by imaging studies (liver and gallbladder ultrasonography, MRCP, or CT), with histological typing performed according to the Todani classification system; 3) First-time surgical resection of the common bile duct cyst combined with radical Roux-en-Y hepatojejunal anastomosis; 4) Complete clinical medical records, preoperative laboratory test data, intraoperative surgical documentation, postoperative rehabilitation and follow-up data; 5) The study cases are affiliated with respective participating research centers, and inpatient and follow-up data can be readily retrieved.

You may not qualify if:

• \) Children with severe end-stage liver cirrhosis, irreversible liver failure, or malignant biliary tract tumors; 2) Children with severe multi-organ failure (e.g., cardiac, pulmonary, or renal failure) who cannot be adequately assessed for surgical prognosis; 3) Children undergoing secondary surgery or those with recurrent choledochal cysts; 4) Children who have only undergone palliative stoma creation or percutaneous drainage without receiving radical surgical intervention; 5) Cases in which critical perioperative clinical data are missing, making it impossible to meet the requirements for data analysis.

Sponsors & Collaborators

• Wuhan Children's Hospital: lead

Study Sites (1)

Wuhan Children'c Hospital

Wuhan, Hubei, 430016, China

Location

MeSH Terms

Conditions

Choledochal Cyst

Condition Hierarchy (Ancestors)

Cysts; Neoplasms; Bile Duct Diseases; Biliary Tract Diseases; Digestive System Diseases; Digestive System Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Xueqiang Yan, Doctor

  Wuhan Children's Hospital

  STUDY CHAIR

• Liang Ge

  Tianjin Children's Hospital

  PRINCIPAL INVESTIGATOR

• Chen Yu

  Anhui Provincial Children's Hospital

  PRINCIPAL INVESTIGATOR

• Zhu Jin

  Zunyi Medical College

  PRINCIPAL INVESTIGATOR

• Xiaoxia Wu

  Shanxi Provincial Maternity and Children's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 20, 2026
• First Posted: September 2, 2026
• Study Start: January 1, 2026
• Primary Completion: July 31, 2026
• Study Completion: July 31, 2026
• Last Updated: September 2, 2026

Record last verified: 2026-08

Locations

CN (1)