Characterisation of MNEsic Involvement in Patients With Obesity.

NCT07796932 | Not Yet Recruiting

• 1 other identifier: CHUBX 2025/068
• Study Type: observational
• Target: 150
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of the study is therefore to characterise memory impairment in a middle-aged population with obesity and to clarify the role of inflammation in obesity-related memory impairment. The hypothesise that, as in an elderly population, neurological and memory impairment in a population of middle-aged obese individuals is heterogeneous, with varying levels of memory impairment characterised by neuropsychological test results. This heterogeneity in neuropsychological tests may be linked to markers of inflammation and brain imaging biomarkers identified previously in the litterature.

Conditions

Obesity (Disorder)

Keywords

neurological inflammation; Obesity; CANTAB

Outcome Measures

Primary Outcomes (1)

• Memory function characteristic

  The main objective is to characterise memory function in a population of middle-aged individuals suffering from obesity using the CANTAB Paired Associates Learning (PAL) test.

  37 months after inclusion day

Study Arms (1)

Magnetic Resonance Imaging, CANTAB questionnaires

Other: RMI and Questionnaires

Interventions

RMI and Questionnaires OTHER

Magnetic resonance imaging (MRI) will collect anatomical information (3D T1 weighted images) to compute the volumes of the hypothalamus, hippocampus and the other brain parcels. Executive functions using the CANTAB tests and validated questionnaires will be performed.

Magnetic Resonance Imaging, CANTAB questionnaires

Eligibility Criteria

• Age: 30 Years - 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Recruitment will take place within the Specialised Obesity Centre at Bordeaux University Hospital. As part of their obesity treatment within the department, new patients first attend a consultation, after which they are usually admitted for a five-day educational programme to undergo a comprehensive initial multidisciplinary assessment (covering medical, dietary, psychological, physical activity and social aspects).

You may qualify if:

• Patients suffering from obesity with a BMI between 30 and 45 kg/m²
• Patients aged between 30 and 50 receiving educational care during the week at the CSO (Endocrinology, Diabetology and Nutrition Department) of the Bordeaux University Hospital.
• Right-handed patients
• Persons affiliated with or beneficiaries of a social security scheme.
• Free, informed and express consent

You may not qualify if:

• Patients currently undergoing treatment with neuroleptics or who have stopped treatment within the last 3 months.
• Pregnant or breastfeeding patients
• Known current or past neurological disease
• Proven depressive syndrome treated
• Patients with type 1 or type 2 diabetes
• Uncontrolled dysthyroidism
• MMS\< 25
• Patients with proven genetic obesity
• Contraindication to MRI
• Chronic use of NSAIDs or corticosteroids
• Loss of 5% of body weight in the 3 months prior to the study
• Acute infection
• Persons deprived of their liberty by judicial or administrative decision
• Adults subject to legal protection measures (guardianship, curatorship, judicial protection)

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

MeSH Terms

Conditions

Obesity

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Daniela COTA, Pr

  INSERM u1215

  STUDY DIRECTOR

Central Study Contacts

Blandine GATTA-CHERIFI, Pr

CONTACT

05 24 54 93 41; blandine.gatta-cherifi@chu-bordeaux.fr

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 22, 2026
• First Posted: September 1, 2026
• Study Start (Estimated): January 1, 2027
• Primary Completion (Estimated): February 1, 2030
• Study Completion (Estimated): February 1, 2030
• Last Updated: September 1, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share