GAS5 Gene Expression and IL-6 in Rheumatoid Arthritis

NCT07796841 | Not Yet Recruiting

• 1 other identifier: Soh-Med-26-8-16MS
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to investigate the expression of Growth Arrest-Specific 5 (GAS5) , a long non-coding RNA , in patients with Rheumatoid Arthritis compared with healthy individuals. The study will also assess the level of Interlukin-6 (IL-6) in the blood and explore the relationship between GAS5 expression and IL-6 levels in Rheumatoid Arthritis

Conditions

RA - Rheumatoid Arthritis

Outcome Measures

Primary Outcomes (1)

• GAS5 gene expression level

  GAS5 long non-coding RNA expression level in preipheral blood samples , assessed by quantitative real-time polymerase chain reaction (qRT-PCR) and compared between patients with rheumatoid arthritis and healthy controls

  at enrollment

Study Arms (2)

Rheumatoid Arthritis

Participants diagnosed with Rhemutoid Arthritis who meet the predefined eligibility criteria and will undergo assessment of GAS5 gene expression and serum interlukin-6 (IL-6) levels

Healthy Controls

Healthy participants without Rheumatoid Arthritis who meet the predefined eligibilty criteria and will undergo assessment of GAS5 gene expression and serum interlukin-6 (IL-6)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients diagnosed with Rheumatoid Arthritis according to 2010 ACR/EULAR classification criteria and healthy controls participants who meet the predefined eligibility criteria

You may qualify if:

• Adult patients older than 18 years patients diagnosed with Rheumatoid Arthritis according to the 2010 American collage Rheumatology / European League against Rheumatism (ACR/EULAR) classification criteria

Sponsors & Collaborators

• Sohag University: lead

Related Publications (1)

• Hegazy GA-F, Shaker O, Aly O, Zaki HH, Herzalla MR, Gomaa AF, Sayed S, Haroon MM. Expression of Two Long Noncoding Ribonucleic Acids (Growth Arrest-Specific 5 and H19) in Rheumatoid Arthritis Patients: Relation to Clinical Characteristics and Disease Activity. Indian Journal of Rheumatology. 2021;16(2):152-158.

  RESULT

MeSH Terms

Conditions

Arthritis, Rheumatoid

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Samar Mohamed Abozaid, Biochemistry demonstrator

  Faculty of Medicine , Sohag University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Samar Mohamed Abozaid, Biochemistry demonstrator

CONTACT

+20 1026386368; sm3962539@gmail.com

Hend Mohamed Omar Naguib, Biochemistry Lecturer

CONTACT

+20 1005287752; Hendmnaguib@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Demonstrator at Biochemistry and Molecular Biology department

Study Record Dates

• First Submitted: August 27, 2026
• First Posted: September 1, 2026
• Study Start: October 1, 2026
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): October 1, 2027
• Last Updated: September 1, 2026

Record last verified: 2026-08