An Exploratory Study to Evaluate Skin Brightening Effects of Different Cosmetic Formulations on UV Irradiated Tanning Model
1 other identifier
interventional
13
0 countries
N/A
Brief Summary
This is a double-blind randomized, complete block design study on Chinese population, expecting approximately 18 participants recruited and at least 10 participants to complete the whole 9-week study. The study test sites will receive a single 2MED UV radiation .
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Sep 2026
Shorter than P25 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 26, 2026
CompletedFirst Posted
Study publicly available on registry
August 31, 2026
CompletedStudy Start
First participant enrolled
September 10, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 11, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
November 11, 2026
August 31, 2026
August 1, 2026
2 months
August 26, 2026
August 26, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
L*, a*, b*, ITA
Measure skin color (L\*, a\*, b\* values, calculate ITA°) on the back test areas using Spectrophotometer, CM-26d.
From 1-week pre-treatment phase to end of study at 8 weeks
Secondary Outcomes (1)
Hydration and barrier function
From 1-week pre-treatment phase to end of study at 8 weeks
Other Outcomes (1)
Image demo
From 1-week pre-treatment phase to end of study at 8 weeks
Study Arms (12)
SMR 1
PLACEBO COMPARATORSMR 2
EXPERIMENTALSMR 3
EXPERIMENTALSMR 4
EXPERIMENTALSMR 5
EXPERIMENTALUntreated
NO INTERVENTIONPro-Derma 1
PLACEBO COMPARATORPro-Derma 2
EXPERIMENTALPro-Derma 3
EXPERIMENTALPro-Derma 4
EXPERIMENTALPro-Derma 5
EXPERIMENTALThiamidol
ACTIVE COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Healthy Chinese female or male, aged from 18 to 50 years old (both inclusive).
- Participants in good health condition as per the health history questionnaire with no disease state or physical condition that the investigator believes could interfere with the interpretation of the data.
- Participant is able to read, understand and sign an appropriate informed consent form indicating his willingness to participate.
- ITA° range 10-42°; Skin type III and IV included and can tolerance 2MED radiation.
- No history of allergic diseases or allergies to cosmetics, UV light and other topical preparations.
- No history of photosensitive diseases and no recent use of medications that affect photosensitivity.
- The test area skin (back) should be free of birthmarks, inflammation, scars, excessive hair, etc.
- No cuts, abrasions, fissures, wounds, lacerations on the test site (back).
- Participants must understand the trial process, voluntarily participate in the study, and sign a written informed consent form.
- Willing to attend the study center twice daily for product application during the study period and complete all visits.
You may not qualify if:
- Study participants are employees of Sponsor or CRO.
- The study participants participated in test involving the test site within 2 months prior to the start of this test or are currently participating in such tests.
- Study participants had any other visible signs of local irritation, erythema, or skin disease on the visible parts of the body.
- Study participants consider they are prone to breakouts and/or sensitive skin.
- Study participants had a chronic illness or had major surgery in the past year.
- Study participants were receiving any skin treatments on the test sites.
- Study participants had allergies or sensitivities to cleansing products, creams/emulsion, costume jewelry, or other things.
- Female study participants were pregnant/breastfeeding or planning to become pregnant during the trial (study participants self-declared at screening visits).
- Study participants took medication for any condition, which the researchers believe may have affected the interpretation of the data.
- Study participants had a history of psoriasis, eczema, atopic dermatitis, severe acne, etc. Or have other chronic systemic diseases.
- Study participants had received oral or topical corticosteroids and other anti-inflammatory drugs within the last 1 month.
- Study participants used tartaric acid, salicylic acid and any other products or drugs that affect skin colour (such as hydroquinones) within the last 2 months.
- Study participants used retinoic acid preparations or aesthetic treatment such as chemical stripping, laser, pulsed light, etc. in the test site in the past three months.
- Study participants were inevitably exposed to prolonged sunlight.
- Clinical evaluation considers that participants are not suitable for the test.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Unilever R&Dlead
MeSH Terms
Interventions
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 26, 2026
First Posted
August 31, 2026
Study Start
September 10, 2026
Primary Completion (Estimated)
November 11, 2026
Study Completion (Estimated)
November 11, 2026
Last Updated
August 31, 2026
Record last verified: 2026-08
Data Sharing
- IPD Sharing
- Will not share