Comparison of KIRA Hydrating Treatment and Jet Peel for Facial Skin Hydration

NCT07793149 | Completed

• 1 other identifier: FFNS-KIRA-JET-01
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 2

Brief Summary

This study compared the efficacy and tolerability of two non-invasive facial treatment systems for improving skin hydration: a hydroabrasion-jet system (KIRA) and a conventional high-pressure jet system (JET PEEL). Twenty-three women aged 30-65 years underwent three treatment sessions using an intraindividual split-face design, with KIRA applied to the left side of the face and JET PEEL to the right side. Skin hydration was assessed by corneometry at baseline, 48 hours after the first treatment, and before the second and third treatments, with the measurement before the third treatment defined as the primary endpoint. Additional exploratory assessments included multispectral skin imaging, participant-reported treatment experience and preference, and a Day-21 follow-up. The study aimed to determine whether enhanced epidermal preparation using hydroabrasion combined with lower-pressure jet infusion could achieve hydration outcomes comparable to those obtained with a conventional higher-pressure jet system.

Conditions

Skin Rejuvenation; Facial Skin Hydration

Keywords

Skin Hydration; Hydroabrasion; Jet Infusion; Corneometry; Topical Delivery; Facial Rejuvenation; Cosmetic Jet Pressure; Epidermal Preparation

Outcome Measures

Primary Outcomes (1)

• Change in Facial Skin Hydration From Baseline to T3

  Facial skin hydration was measured separately on the KIRA-treated and JET PEEL-treated facial sides using corneometry. The primary outcome was the change in corneometer-measured skin hydration, expressed in arbitrary units (a.u.), from baseline (T0) to T3, measured before the third treatment session. The within-participant difference in change between the two facial sides was used for the primary comparison.

  Baseline (T0) to before the third treatment session (T3; approximately 14 days)

Study Arms (2)

Arm 1: KIRA Treatment - Left Facial Side

EXPERIMENTAL

Participants received treatment with the KIRA hydroabrasion-jet system on the left facial side. The protocol consisted of vacuum-assisted hydroabrasion for epidermal preparation followed by 5-bar jet infusion. Three treatment sessions were performed according to the study protocol.

Device: Hydroabrasion and Jet Infusion

Arm 2: JET PEEL Treatment - Right Facial Side

ACTIVE COMPARATOR

Participants received treatment with the JET PEEL system on the right facial side. The protocol consisted of jet-based treatment and infusion at 6.89 bar. Three treatment sessions were performed according to the study protocol.

Device: High-Pressure Jet Infusion

Interventions

Hydroabrasion and Jet Infusion DEVICE

Vacuum-assisted hydroabrasion was used for epidermal preparation, followed by jet infusion at 5 bar. The intervention was applied to the left facial side during three treatment sessions.

Arm 1: KIRA Treatment - Left Facial Side

High-Pressure Jet Infusion DEVICE

Jet-based treatment and infusion at 6.89 bar was applied to the right facial side during three treatment sessions.

Arm 2: JET PEEL Treatment - Right Facial Side

Eligibility Criteria

• Age: 30 Years - 65 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Female participants aged 30-65 years Fitzpatrick skin types II-III Presence of signs of facial skin aging, including one or more of the following: hyperkeratosis, hyperpigmentation, facial or age-related wrinkles, and enlarged pores Generally healthy and without contraindications to the study procedures Willing and able to provide informed consent and participate in the study procedures

Sponsors & Collaborators

• Faculty of Pharmacy Novi Sad: lead

Study Sites (2)

Laser Center Be You, Be You Technology d.o.o.

Belgrade, 11000, Serbia

Location

Mella Cosmetics Doo Beograd

Belgrade, 11000, Serbia

Location

Study Officials

• Katarina Obradovic

  Faculty of Pharmacy Novi Sad, University Business Academy in Novi Sad

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Outcome assessors performing the instrumental skin measurements were independent from the treatment procedure and were unaware whether participants had undergone treatment and which intervention had been applied to each side of the face.
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctoral Candidate

Model Details: Intraindividual split-face comparative study. Each participant received both interventions during the same treatment sessions: KIRA was applied to the left side of the face and JET PEEL to the right side. Outcomes were assessed separately for each facial side, allowing within-participant comparison of the two interventions.

Study Record Dates

• First Submitted: August 25, 2026
• First Posted: August 28, 2026
• Study Start: May 18, 2026
• Primary Completion: June 22, 2026
• Study Completion: July 14, 2026
• Last Updated: August 28, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

SE (2)