Antioxidant Nutrition and Facial Exercise for Skin Aging

NCT07792447 | Not Yet Recruiting

• 1 other identifier: UOZ-FACE-2026-02
• Study Type: interventional
• Target: 120
• Locations: 0 countries
• Sites: N/A

Brief Summary

This randomized controlled trial will evaluate the effects of a 12-week combined antioxidant-rich nutrition and facial exercise program on skin quality and wrinkle severity in middle-aged women. Participants will be randomly assigned to an intervention group or a control group. The intervention group will follow a structured antioxidant-rich dietary program combined with facial exercises, while the control group will maintain their usual lifestyle. Skin quality and wrinkle-related outcomes will be assessed at baseline and after the 12-week intervention using standardized objective measurements

Conditions

Facial Skin Aging and Wrinkle Severity

Keywords

Facial Exercise; Skin Aging; Facial Wrinkles; Middle-Aged Women

Outcome Measures

Primary Outcomes (1)

• Change in Mean Crow's Feet Wrinkle Depth

  Change in the mean bilateral crow's feet wrinkle depth from baseline to week 12, assessed using standardized three-dimensional skin imaging. Measurements will be obtained from both sides of the face and averaged to provide the participant-level value. Lower post-intervention values indicate improvement in wrinkle depth

  Baseline to 12 weeks

Study Arms (2)

intervention group

EXPERIMENTAL

Participants in the intervention group will follow a 12-week combined antioxidant-rich nutrition and facial exercise program

Behavioral: Combined Antioxidant Nutrition and Facial Exercise Program

control group

NO INTERVENTION

Participants in the control group will maintain their usual diet, skincare routine, and daily lifestyle without receiving the study intervention during the 12-week period

Interventions

Combined Antioxidant Nutrition and Facial Exercise Program BEHAVIORAL

Participants in the intervention group will complete a 12-week combined program consisting of an antioxidant-rich dietary intervention and structured facial exercises. The dietary component will emphasize regular consumption of antioxidant-rich foods, while the facial exercise component will target major facial muscle groups according to a standardized exercise protocol. Participants will be instructed to follow the program throughout the 12-week intervention period

intervention group

Eligibility Criteria

• Age: 45 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Female participants aged 45-50 years. Willing and able to participate in the 12-week intervention program. Willing to follow the assigned dietary and facial exercise program. Willing to maintain their usual skincare routine unless otherwise instructed by the study protocol. Able to provide informed consent.

You may not qualify if:

• Current smoking. Facial aesthetic procedures such as botulinum toxin injections, dermal fillers, laser treatment, chemical peels, or similar procedures within the predefined period before enrollment. Current dermatological disease or skin condition that may affect facial skin measurements. Uncontrolled chronic medical conditions that may influence skin health or participation in the intervention. Planned initiation of new skincare treatments, cosmetic products, or aesthetic procedures during the 12-week study period. Inability to perform the facial exercise program safely or comply with the dietary intervention and study procedures

Sponsors & Collaborators

• University of Zakho: lead

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 25, 2026
• First Posted: August 28, 2026
• Study Start: August 25, 2026
• Primary Completion: August 25, 2026
• Study Completion (Estimated): November 25, 2026
• Last Updated: August 28, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share