Digital Intervention for Healthcare Workers

NCT07791563 | Not Yet Recruiting

• 2 other identifiers: 2025-0594UM1TR005438
• Study Type: interventional
• Target: 201
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to test which engagement strategies lead to more participation in a digital mental health program among healthcare workers. The main questions it aims to answer is:

• Does content tailoring increase engagement with the digital program?
• Does human support increase engagement with the digital program? Researchers will compare the general intervention to a tailored intervention and to the tailored intervention with human support coaching to see what leads to more engagement with/use of the program. Participants will:
• Use a digital program weekly for 6 weeks
• Complete questionnaires at 5 times: Start of study, Week 2, Week 3 (mid-program), Week 6 (end of program), and Week 10 (follow-up)

Conditions

Healthcare Workforce Well-Being

Keywords

digital mental health interventions; engagement; healthcare workers

Outcome Measures

Primary Outcomes (4)

• Engagement with the intervention (subjective)

  The primary outcome is engagement with intervention. Subjective engagement will be measured via the TWente Engagement with Ehealth Technologies Scale (TWEETS), a 9-item measure aimed at assessing behavioral engagement, cognitive engagement, and affective engagement. A higher total score reflects a greater, more positive engagement with the digital health intervention.

  From start of intervention to end of intervention period at 6 weeks.

• Engagement - Number of Lessons

  An objective measure of engagement with the digital intervention is number of lessons read (i.e., module completion). More lessons read reflects more engagement with the intervention.

  From start of intervention to end of intervention period at 6 weeks.

• Engagement - Number of Tools

  An objective measure of engagement with the digital intervention is number of tools completed (i.e., tool usage). More tools completed reflects more engagement with the intervention.

  From start of intervention to end of intervention period at 6 weeks.

• Engagement - Duration of Time

  An objective measure of engagement with the digital intervention is the duration of time participants spend on the digital intervention site. More time on the site reflects more engagement with the intervention.

  From start of intervention to end of intervention period at 6 weeks.

Secondary Outcomes (3)

• Burnout

  From baseline to follow-up at 10 weeks.

• Depressive Symptoms

  From baseline to follow-up at 10 weeks.

• Anxiety symptoms

  From baseline to follow-up at 10 weeks.

Study Arms (3)

Control Group

ACTIVE COMPARATOR

Infographic onboarding and the Cognitive Behavioral Therapy (CBT)-based 6-week digital mental health intervention.

Behavioral: Engage

Content Tailoring Group

EXPERIMENTAL

Healthcare-worker-tailored infographic onboarding and the Cognitive Behavioral Therapy (CBT)-based 6-week digital mental health intervention with healthcare worker tailoring.

Behavioral: HCW-Tailored Engage

Content Tailoring Plus Human Support Group

EXPERIMENTAL

An onboarding engagement call with a human coach and the Cognitive Behavioral Therapy (CBT)-based 6-week digital mental health intervention with healthcare worker tailoring, plus human support via messaging (coaching).

Behavioral: HCW-Tailored Engage

Interventions

Engage BEHAVIORAL

The digital mental health intervention is based on Cognitive Behavioral Therapy principles and consists of learning modules covering basic skills (e.g., behavioral activation) and interactive tools to assist in learning and implementing the skills associated with the learning modules. Interactive tools are designed to support implementation of cognitive behavioral skills including activity scheduling and monitoring, cognitive restructuring, goal setting, relaxation, and mood tracking.

Control Group

HCW-Tailored Engage BEHAVIORAL

The digital mental health intervention is based on Cognitive Behavioral Therapy principles and consists of learning modules covering basic skills (e.g., behavioral activation) and interactive tools to assist in learning and implementing the skills associated with the learning modules. Interactive tools are designed to support implementation of cognitive behavioral skills including activity scheduling and monitoring, cognitive restructuring, goal setting, relaxation, and mood tracking. This version of the intervention contains content tailored specifically for healthcare workers, based on findings from a co-design, qualitative focus group process.

Content Tailoring Group; Content Tailoring Plus Human Support Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 years or older, all sexes
• Currently working in healthcare in the US with at least 4 hours per week of direct patient contact
• Stable access to internet
• Have a total score between 3-14 on the PHQ-9 (Patient Health Questionnaire-9), suggestive of mild to moderate depressive symptoms

You may not qualify if:

• Have a total score of ≥15 on the PHQ-9, indicating Severe Depressive symptoms.
• Currently diagnosed with a psychotic disorder or bipolar disorder, based on self-report.
• Currently receiving psychotherapy for depression or anxiety based on self-report; If on medications for depression or anxiety, must be on a stable dose of medication for at least 2 weeks.

Sponsors & Collaborators

• University of Illinois at Chicago: lead
• National Center for Advancing Translational Sciences (NCATS): collaborator

Study Sites (1)

Neuropsychiatric Institute

Chicago, Illinois, 60612, United States

Location

MeSH Terms

Interventions

engage 8200

Central Study Contacts

Jennifer Duffecy, PhD

CONTACT

312-413-1225; jduffecy@uic.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 24, 2026
• First Posted: August 28, 2026
• Study Start (Estimated): November 1, 2026
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): March 1, 2028
• Last Updated: August 28, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)