CERVICAL EPIDURAL BLOCK IN CHRONIC NECK PAIN
CNP-TREAT
COMPARISON OF CERVICAL EPIDURAL BLOCK ALONE VERSUS COMBINED TREATMENT MODALITIES IN CHRONIC NECK PAIN
1 other identifier
interventional
60
1 country
1
Brief Summary
Chronic neck pain can negatively affect daily activities, work ability, and quality of life. Cervical epidural block is commonly used to reduce pain and inflammation, while exercise and physical therapy aim to improve muscle strength, endurance, movement control, and physical function. However, there is limited evidence comparing cervical epidural block alone with its combined use with exercise or physical therapy. This study aims to compare the effects of three treatment approaches in patients with chronic neck pain associated with cervical disc pathology or degenerative changes. Participants will receive cervical epidural block alone, cervical epidural block combined with cervical stabilization exercises, or cervical epidural block combined with physical therapy. Pain intensity, neck-related disability, and quality of life will be evaluated before treatment and at 1, 3, and 6 months after treatment using the Numeric Rating Scale, Neck Disability Index, and 12-Item Short Form Health Survey. The study will determine whether adding exercise or physical therapy to cervical epidural block provides additional clinical and functional benefits.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jul 2026
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2026
CompletedFirst Submitted
Initial submission to the registry
August 22, 2026
CompletedFirst Posted
Study publicly available on registry
August 26, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 1, 2027
August 26, 2026
August 1, 2026
1.3 years
August 22, 2026
August 22, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in Pain Intensity Assessed by the Numeric Rating Scale
Pain intensity will be assessed using the Numeric Rating Scale (NRS). Participants rate their pain on an 11-point scale ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Lower scores indicate lower pain intensity. Changes from baseline will be compared among the three treatment groups.
Baseline and 1, 3, and 6 months after treatment
Secondary Outcomes (2)
Change in Neck-Related Disability Assessed by the Neck Disability Index
Baseline and 1, 3, and 6 months after treatment
Change in Health-Related Quality of Life Assessed by the 12-Item Short Form Health Survey
Baseline and 1, 3, and 6 months after treatment
Study Arms (3)
Cervical Epidural Steroid Injection
EXPERIMENTALParticipants in this arm receive cervical epidural steroid injection alone.
Cervical Epidural Steroid Injection With Cervical Stabilization Exercises
EXPERIMENTALParticipants in this arm receive cervical epidural steroid injection combined with a cervical stabilization exercise program.
Cervical Epidural Steroid Injection With Physical Therapy
EXPERIMENTALParticipants in this arm receive cervical epidural steroid injection combined with a physical therapy program.
Interventions
Participants receive a cervical epidural steroid injection for the treatment of chronic neck pain associated with cervical radiculopathy.
Participants perform a cervical stabilization exercise program in addition to cervical epidural steroid injection.
Participants receive a physical therapy program in addition to cervical epidural steroid injection.
Eligibility Criteria
You may qualify if:
- Aged 18 to 55 years
- Neck pain lasting longer than 3 months
- Diagnosis of cervical radiculopathy
- Numeric Rating Scale (NRS) pain score of 5 or higher
You may not qualify if:
- History of spinal surgery
- Cervical spondylolisthesis
- Spinal stenosis
- Presence of a neurological deficit
- History of psychiatric disease
- Polyneuropathy
- History of spinal fracture
- Pregnancy
- History of malignancy
- Known allergy to any medication used in the study
- Central sensitization
- Widespread pain
- Regional pain associated with a systemic disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Alİ Eman, MDlead
Study Sites (1)
Sakarya Training and Research Hospital
Adapazarı, Sakarya, 54100, Turkey (Türkiye)
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
KEMAL NAS, MD, Professor
Sakarya University Training and Research Hospital, Department of Algology
- STUDY CHAIR
RIDVAN IŞIK, MD
Sakarya University Training and Research Hospital, Department of Algology
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Associate Professor, Department of Anesthesiology and Reanimation
Study Record Dates
First Submitted
August 22, 2026
First Posted
August 26, 2026
Study Start
July 1, 2026
Primary Completion (Estimated)
October 1, 2027
Study Completion (Estimated)
October 1, 2027
Last Updated
August 26, 2026
Record last verified: 2026-08
Data Sharing
- IPD Sharing
- Will not share