Impact of Intraoperative Perfusion Variability on Postoperative Troponin Elevation in Geriatric Patients Undergoing Major Oncologic Surgery

NCT07786753 | Not Yet Recruiting

• 1 other identifier: AOH2026-05/89
• Study Type: observational
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective observational study aims to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation in geriatric patients undergoing major oncologic surgery. Intraoperative hemodynamic and perfusion-related parameters will be recorded, and postoperative troponin levels will be assessed to investigate whether intraoperative perfusion changes are associated with myocardial injury. Troponin measurements will be obtained preoperatively and at 24 hours after surgery

Conditions

Postoperative Troponin Elevation; Intraoperative Perfusion

Keywords

Postoperative Troponin Elevation; Geriatric Patients; Major Oncologic Surgery; Intraoperative Perfusion; Troponin; Hemodynamic Variability

Outcome Measures

Primary Outcomes (1)

• Change in Serum Troponin Concentration From Preoperative Baseline to 24 Hours After Surgery

  Postoperative troponin elevation will be assessed by comparing serum troponin levels measured preoperatively and 24 hours after surgery. Its association with intraoperative perfusion variability will be evaluated.

  Preoperatively and 24 hours after surgery

Secondary Outcomes (3)

• Association Between Intraoperative Perfusion Index and Postoperative Troponin Elevation

  Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively

• Association Between Intraoperative Pleth Variability Index and Postoperative Troponin Elevation

  Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively.

• Association Between Intraoperative Cerebral Oxygen Saturation and Postoperative Troponin Elevation

  Intraoperative monitoring from the start to the end of surgery; troponin measured preoperatively and at 24 hours postoperatively.

Study Arms (1)

Geriatric Patients Undergoing Major Oncologic Surgery

Geriatric patients undergoing elective major oncolojic surgery will be prospectively observed.Intraoperative hemodynamic and perfusion-related parameters will be recorded, and serum troponin levels will be measured preoperatively and 24 hours after surgery to evaluate the association between intraoperative perfusion variability and postoperative troponin elevation.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Geriatric patients aged 65 years or older undergoing major abdominal oncologic surgery who meet the predefined eligibility criteria and have preoperative and 24-hour postoperative troponin measurements. Intraoperative hemodynamic and perfusion parameters, including PI, PVI, and cerebral oxygen saturation measured by NIRS, will be monitored throughout surgery and recorded at 15-minute intervals.

You may qualify if:

• Age 65 years or older
• Undergoing major abdominal oncologic surgery
• Availability of preoperative and 24-hour postoperative troponin measurements
• Complete intraoperative and postoperative patient monitoring records
• Provision of written informed consent

You may not qualify if:

• Age younger than 65 years
• Absence of preoperative or 24-hour postoperative troponin measurements
• Incomplete intraoperative or postoperative patient monitoring records
• Undergoing emergency surgery
• Advanced heart failure
• ASA Physical Status IV
• Pulmonary artery pressure \>40 mmHg

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Ankara Dr. Abdurrahman Yurtaslan Oncolgy Training and Research Hospital

Yenimahalle, Ankara, 06200, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 21, 2026
• First Posted: August 26, 2026
• Study Start: September 1, 2026
• Primary Completion (Estimated): November 2, 2026
• Study Completion (Estimated): November 2, 2026
• Last Updated: September 16, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)