Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations

NCT07786467 | Not Yet Recruiting

• 1 other identifier: 33-007
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with advanced age and/or adiposity.

Conditions

No Disease or Condition is Being Directly Studied; The Focus of the Study in Healthy Volunteers

Keywords

Osteopathic Manipulation; Influenza vaccine; Aging; Body composition

Outcome Measures

Primary Outcomes (1)

• Hemagglutinin inhibition assay

  Hemagglutinin inhibition assay assess the antibody titers in patient's blood.

  baseline and 4 weeks post vaccination

Study Arms (3)

Thoracic pump only

ACTIVE COMPARATOR

Only thoracic inlet myofascial release

Other: Osteopathic Manipulation

No intervention

SHAM COMPARATOR

No intervention pre- or post-influenza vaccination.

Other: Sham

Complete lymphatic pumping

EXPERIMENTAL

Multiple sites of OMT to occur post-influenza vaccination.

Other: Osteopathic manipulation

Interventions

Osteopathic manipulation OTHER

In this intervention, participants will receive 5 minutes of thoracic inlet myofascial release 2 days prior to influenza vaccination, the day of influenza vaccination and 4 days post-influenza vaccination.

Thoracic pump only

Sham OTHER

In this intervention, participants will receive no osteopathic treatments

No intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Willing to receive OMT
• Willing to receive influenza vaccine
• Older than 18 years of age

You may not qualify if:

• Younger than 18 years of age
• Pregnancy or lactation
• Unwilling to receive the influenza vaccine
• Unwilling to receive OMT
• Open wounds
• Bone fractures
• Moderate to severe osteoporosis
• Severe COPD
• Current/active infections
• Mononucleosis infection within past 6 months
• Liver cirrhosis
• Cancer or metastatic disease
• History of DVT, PE, or blood clotting disorder
• Individuals taking blood thinning medications, except aspirin
• Having a pacemaker or other thoracic medical devices

Sponsors & Collaborators

• Lake Erie College of Osteopathic Medicine: lead

Study Sites (1)

Plaza 38 Medical Offices

Erie, Pennsylvania, 16509, United States

Location

MeSH Terms

Conditions

Influenza, Human

Interventions

Manipulation, Osteopathic; salicylhydroxamic acid

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Musculoskeletal Manipulations; Complementary Therapies; Therapeutics; Physical Therapy Modalities; Rehabilitation

Study Officials

• David Duriancik, Ph.D.

  Lake Erie College of Osteopathic Medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

David Duriancik, Ph.D.

CONTACT

814-860-5139; dduriancik@lecom.edu

Irv Freeman, J.D., Ph.D.

CONTACT

724-552-2870; ifreeman1@lecom.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 22, 2026
• First Posted: August 26, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): October 1, 2027
• Last Updated: August 27, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)