Internal Jugular Vein Collapsibility Index for Volume Status Assessment in Preeclampsia in Correlation With Normotensive Parturients : a Prospective Observational Cohort Study

NCT07786246 | Recruiting DMC

• 1 other identifier: 36264MS101010/10/25
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to assess and analyze volume status in preeclamptic patients and compare these parameters with those of normotensive pregnant ones based on the change in internal jugular vein ultrasound-based indices.

Conditions

Preeclampsia

Outcome Measures

Primary Outcomes (1)

• Measuring internal jugular vein (IJV) collapsibility index

  Measuring internal jugular vein (IJV) collapsibility index at end expiratory phase just before the induction of anesthesia and its correlation with normotensive parturients to determine the cut off value of fluid status in preeclamptic patient

  Intra-operative

Secondary Outcomes (2)

• Association between internal jugular vein ultrasound-based indices and severity of Preeclampsia.

  Intra-operative

• Value of internal Jugular vein collapsibility index in predicting post spinal hypotension

  Intra-operative

Study Arms (2)

Preeclamptic Group

Parturients diagnosed with preeclampsia diagnosed according to established diagnostic criteria of ISSHP: Pregnant female in the third trimester (after 20 weeks of pregnancy).

Control Group

Normotensive Parturients matched for gestational age at the time of Ultrasound.

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Patients admitted at obstetric theater in Tanta University Hospital

You may qualify if:

• Singleton parturients from 18 to 40 years old.
• Either normotensive or preeclamptic parturients scheduled for elective cesarean section under neuro-axial block matched for gestational age 28-40 weeks will be included:
• Normotensive group: uncomplicated normotensive pregnancy with systolic blood pressure below 140 mmHg and diastolic blood pressure below 90mmHg without proteinuria.
• Preeclamptic Group: new onset preeclamptic pregnant female with gestational hypertension after 20 weeks of pregnancy diagnosed based on ISSHP Guidelines: systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg, accompanied by one or more of the following:
• Proteinuria (≥300 mg in a 24-hour urine sample)
• Alb/Cr ratio ≥30 mg/mmol,
• Organ dysfunction (renal insufficiency (creatinine level\>1.1mg%), liver involvement (liver enzyme levels ≥3 times normal), neurological complications (Headache and blurring of vision) and hematological involvement (thrombocytopenia\<100.000)).

You may not qualify if:

• Parturients with pre-existing cardiac \& vascular disease affecting blood volume and vascular compliance: (Valvular or congenital heart disease, arrhythmia, previous history of venous thromboembolism, chronic kidney disease, gestational diabetes).
• multiple gestations
• known thyroid disorders or chronic hypertension
• patients with BMI \>40 and patients requiring emergency delivery.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University Hospital

Tanta, El-Gharbia Govenorate, 31527, Egypt

RECRUITING

MeSH Terms

Conditions

Pre-Eclampsia

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Central Study Contacts

Abdelghany AA Mohamed, MBBCH

CONTACT

+201123676274; Aldomiaty97@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of Anesthesia, Surgical Intensive Care and Pain Management

Study Record Dates

• First Submitted: August 21, 2026
• First Posted: August 25, 2026
• Study Start: October 1, 2025
• Primary Completion (Estimated): September 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: August 25, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will share
• Access Criteria: The data will be available upon a reasonable request from the corresponding author

Locations

EG (1)