Trials Sponsors Conditions Drugs Pricing

Conditions

Autoimmune Hepatitis Autoimmune Liver Disease Primary Biliary Cholangitis (PBC)Primary Sclerosing Cholangitis (PSC)

Outcome Measures

Primary Outcomes (1)

Establish the molecular signature of autoimmune self-antigen-specific T cells in AILD
4 years

Study Arms (1)

AILD Patients

Patients with Auto-Immune Hepatitis

Eligibility Criteria

Sexall

Healthy VolunteersNo

Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Patients with Auto-Immune Hepatitis

You may qualify if:

Patient informed consent

Sponsors & Collaborators

Nantes University Hospital
Otherlead

Study Sites (1)

Nantes University Hospital

Nantes, 44093, France

Related Publications (2)

Cardon A, Guinebretiere T, Dong C, Gil L, Ado S, Gavlovsky PJ, Braud M, Danger R, Schultheiss C, Domene A, Paul-Gilloteaux P, Chevalier C, Bernier L, Judor JP, Fourgeux C, Imbert A, Khaldi M, Bardou-Jacquet E, Elkrief L, Lannes A, Silvain C, Schnee M, Tanne F, Vavasseur F, Brusselle L, Brouard S, Kwok WW, Mosnier JF, Lohse AW, Poschmann J, Binder M, Gournay J, Conchon S, Milpied P, Renand A. Single cell profiling of circulating autoreactive CD4 T cells from patients with autoimmune liver diseases suggests tissue imprinting. Nat Commun. 2025 Jan 29;16(1):1161. doi: 10.1038/s41467-025-56363-2.
PMID: 39880819RESULT
Imbert A, Gavlovsky PJ, Judor JP, Bardou-Jacquet E, Elkrief L, Lannes A, Silvain C, Schnee M, Tanne F, Chevalier C, Vavasseur F, Khaldi M, Brouard S, Mosnier JF, Gournay J, Conchon S, Renand A. T cell immuno-phenotyping : a source of predictive biomarkers for autoimmune hepatitis relapse. Sci Rep. 2024 Oct 18;14(1):24448. doi: 10.1038/s41598-024-75624-6.
PMID: 39424872

MeSH Terms

Conditions

Hepatitis, AutoimmuneLiver Cirrhosis, BiliaryCholangitis, Sclerosing

Condition Hierarchy (Ancestors)

Hepatitis, ChronicHepatitisLiver DiseasesDigestive System DiseasesAutoimmune DiseasesImmune System DiseasesCholestasis, IntrahepaticCholestasisBile Duct DiseasesBiliary Tract DiseasesLiver CirrhosisFibrosis

Study Officials

Jérôme Gournay
Nantes University Hospital
PRINCIPAL INVESTIGATOR

Enrollment

220 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: RETROSPECTIVE
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

August 20, 2026

First Posted

August 25, 2026

Study Start

April 20, 2021

Actual (reported)

Deciphering the Self-antigen Specific T Cell Signature of Autoimmune Liver Diseases

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

AILD Patients

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (2)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Documents

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

Primary Completion

Study Completion

First Submitted

First Posted

Conditions

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

AILD Patients

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Publications (2)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Documents

Locations