Study on the Microbial Environment of Non-small Cell Lung Cancer Based on Mycogenomics and Its Clinical Relevance

NCT07783971 | Recruiting

• 1 other identifier: microbial environment
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to uncover the characteristics of the fungal flora in non-small cell lung cancer, and to investigate the relationship between pulmonary fungi and the various pathological subtypes, stages, clinical features of non-small cell lung cancer, as well as patient prognosis. It seeks to provide new perspectives for a comprehensive understanding of non-small cell lung cancer, as well as new approaches for its early diagnosis and prognosis assessment.

Conditions

Fungal Diseases; Lung Cancer (NSCLC); Microbioata

Keywords

the lung microbiome

Outcome Measures

Primary Outcomes (1)

• the fungal microbial environment

  Different fungal microbial environments were observed in different parts of lung tissue.

  baseline, pre-surgery

Study Arms (2)

Lung cancer group

The samples included in this group were lung cancer tissues.

Normal lung tissue group

The samples included in this group were normal lung tissues.

Eligibility Criteria

• Age: 30 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The research object is the patients who are newly diagnosed as "non-small cell lung cancer" and intend to undergo surgical resection

You may qualify if:

• Non-small cell lung cancer was diagnosed by biopsy before operation, frozen pathology during operation or paraffin section after operation; The patients were 30 to 80 years old; No chemotherapy, radiotherapy, targeted therapy or immunotherapy were given before operation;

Sponsors & Collaborators

• 958th Army Hospital of the Chinese People's Liberation Army: lead

Study Sites (1)

958th Army Hospital

Chongqing, Liangjiang New, 400020, China

RECRUITING

Related Publications (3)

• Dohlman AB, Klug J, Mesko M, Gao IH, Lipkin SM, Shen X, Iliev ID. A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors. Cell. 2022 Sep 29;185(20):3807-3822.e12. doi: 10.1016/j.cell.2022.09.015.

  PMID: 36179671 BACKGROUND

• Liu NN, Yi CX, Wei LQ, Zhou JA, Jiang T, Hu CC, Wang L, Wang YY, Zou Y, Zhao YK, Zhang LL, Nie YT, Zhu YJ, Yi XY, Zeng LB, Li JQ, Huang XT, Ji HB, Kozlakidis Z, Zhong L, Heeschen C, Zheng XQ, Chen C, Zhang P, Wang H. The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells. Cancer Cell. 2023 Nov 13;41(11):1927-1944.e9. doi: 10.1016/j.ccell.2023.08.012. Epub 2023 Sep 21.

  PMID: 37738973 BACKGROUND

• Narunsky-Haziza L, Sepich-Poore GD, Livyatan I, Asraf O, Martino C, Nejman D, Gavert N, Stajich JE, Amit G, Gonzalez A, Wandro S, Perry G, Ariel R, Meltser A, Shaffer JP, Zhu Q, Balint-Lahat N, Barshack I, Dadiani M, Gal-Yam EN, Patel SP, Bashan A, Swafford AD, Pilpel Y, Knight R, Straussman R. Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions. Cell. 2022 Sep 29;185(20):3789-3806.e17. doi: 10.1016/j.cell.2022.09.005.

  PMID: 36179670 BACKGROUND

Related Links

• The project has been put on record in China medical research filing system.

Biospecimen

Retention: SAMPLES WITH DNA

Lung tissue

MeSH Terms

Conditions

Mycoses; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung

Condition Hierarchy (Ancestors)

Bacterial Infections and Mycoses; Infections; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Carcinoma, Bronchogenic; Bronchial Neoplasms

Central Study Contacts

shunhong wang project leader

CONTACT

023-68762084; wangshunhong918@163.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident physician

Study Record Dates

• First Submitted: August 1, 2026
• First Posted: August 25, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): January 30, 2028
• Study Completion (Estimated): August 1, 2028
• Last Updated: August 25, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)