Predictors of ICU Admission and In-Hospital Mortality in Hospitalized Patients With Lupus Nephritis: The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and C Reactive Protein to Serum Albumin Ratio

NCT07783711 | Not Yet Recruiting

• 1 other identifier: Prognosis in lupus nephritis
• Study Type: observational
• Target: 55
• Locations: 0 countries
• Sites: N/A

Brief Summary

To identify clinical and laboratory predictors of ICU admission and in-hospital mortality among hospitalized adults with lupus nephritis by evaluating the prognostic performance of NLR and CAR, comparing them with CRP and albumin using ROC analysis, determining optimal cutoff values, and identifying independent predictors through multivariable logistic regression

Conditions

Lupus Nephritis (LN)

Keywords

NLR CAR

Outcome Measures

Primary Outcomes (1)

• Number of participants of ICU admission or In-hospital mortality.

  8 weeks

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hospitalized adult patients with Lupus Nephritis.

You may qualify if:

• Age ≥18 years.
• Diagnosis of systemic lupus erythematosus according to the 2019 EULAR/ACR Classification Criteria.
• Biopsy-proven lupus nephritis or clinically diagnosed lupus nephritis according to the treating nephrologist based on clinical, laboratory and immunological findings.
• Hospitalization because of active lupus nephritis or complications related to lupus nephritis.
• Provision of written informed consent.

You may not qualify if:

• Age below 18 years.
• Previous kidney transplantation.
• Maintenance dialysis for more than three months before hospital admission.
• Active malignancy.
• Pregnancy.
• Refusal to participate

Sponsors & Collaborators

• Khaled Samir Malak Nashed: lead
• Assiut University: collaborator

Related Publications (1)

• Chen Y, Wu X, Chen X, Li M, Luo C, Shi Y, Li J, Wu L. Correlations of baseline neutrophil-lymphocyte ratio with prognosis of patients with lupus nephritis: A single-center experience. Rheumatol Immunol Res. 2023 Dec 19;4(4):196-203. doi: 10.2478/rir-2023-0029. eCollection 2023 Dec.

  PMID: 38125645 BACKGROUND

MeSH Terms

Conditions

Lupus Nephritis

Condition Hierarchy (Ancestors)

Glomerulonephritis; Nephritis; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Lupus Erythematosus, Systemic; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Samir Kamal

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Khaled Samir Malak

CONTACT

+201554715247; Khaled.18313263@med.aun.edu.eg

Alaa Omar Ahmed

CONTACT

+201023658355; Alaa_omar11@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Khaled Samir Malak

Study Record Dates

• First Submitted: August 21, 2026
• First Posted: August 25, 2026
• Study Start (Estimated): September 1, 2026
• Primary Completion (Estimated): September 1, 2028
• Study Completion (Estimated): October 1, 2028
• Last Updated: August 26, 2026

Record last verified: 2026-08