Feasibility Randomised Controlled Trial Exploring Implementation of the Compassionate Mindful rEsilience pRogram for People With pUlmonaRY Fibrosis: The MERcURY Study

NCT07782060 | Completed

• 2 other identifiers: MHLS 24_139SB\ZA\101010662\980079
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

Pulmonary fibrosis (PF) is a chronic lung condition in which scar tissue gradually forms, impairing oxygen transfer and causing breathlessness. Individuals with PF frequently experience anxiety and depression, yet supportive care remains underdeveloped, and few evidence-based psychological interventions exist for this population, representing a critical gap in care. This feasibility randomised controlled trial (RCT) evaluated the Compassionate Mindful Resilience (CMR) programme, a 4-week online, nurse-led mindfulness-based intervention designed to improve psychological outcomes in people living with PF.

Conditions

Pulmonary Fibrosis

Outcome Measures

Primary Outcomes (1)

• Feasibility of the intervention

  Adherence

  From enrollment until the follow up interview was completed (up to 10 weeks)

Secondary Outcomes (1)

• The feasibility of collecting data on anxiety, depression, well-being, mindfulness, resilience, and self-compassion

  Baseline (week 1), post-CMR (week 4), and four-week follow-up (week 8)

Other Outcomes (1)

• Feasibility of recruitment and retention

  From recruitment until the end of the study (up to 5 months)

Study Arms (2)

Intervention group

EXPERIMENTAL

CMR is an internationally accredited 4-week programme with 2-hour online sessions delivered via Microsoft Teams

Behavioral: Compassionate mindful resilience

Waitlist group

NO INTERVENTION

This group did not receive the CMR intervention until all intervention groups had completed CMR.

Interventions

Compassionate mindful resilience BEHAVIORAL

It is an internationally accredited 4-week programme with 2-hour online sessions delivered via Microsoft Teams

Intervention group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• have a confirmed diagnosis of PF
• be aged 18 years or older
• reside in the UK or Ireland
• have the capacity to provide informed consent
• demonstrate a commitment to attend all four CMR sessions (demonstrated through discussion with the mindfulness teacher during screening)
• have access to an internet-enabled device.

You may not qualify if:

• No diagnosis of PF
• under 18 years old
• live outside of UK or Ireland
• no capacity to provide informed consent
• not willing to attend all four CMR sessions
• no access to an internet-enabled device.

Sponsors & Collaborators

• Queen's University, Belfast: lead

Study Sites (1)

Queen's University Belfast

Belfast, Please Select, BT7 1NN, United Kingdom

Location

Related Publications (2)

• Mc Veigh C, Reid J, Larkin P, Porter S, Hudson P. Palliative care for people with non-malignant respiratory disease and their carers: a review of the current evidence. J Res Nurs. 2019 Sep;24(6):420-430. doi: 10.1177/1744987119840066. Epub 2019 Apr 29.

  PMID: 34394556 BACKGROUND

• Mc Veigh C, Reid J, Larkin P, Porter S, Hudson P. The experience of palliative care service provision for people with non-malignant respiratory disease and their family carers: An all-Ireland qualitative study. J Adv Nurs. 2018 Feb;74(2):383-394. doi: 10.1111/jan.13453. Epub 2017 Nov 27.

  PMID: 28910509 BACKGROUND

MeSH Terms

Conditions

Pulmonary Fibrosis

Condition Hierarchy (Ancestors)

Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: August 12, 2026
• First Posted: August 24, 2026
• Study Start: December 1, 2024
• Primary Completion: April 21, 2025
• Study Completion: July 18, 2025
• Last Updated: August 24, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)