Supported Online Self-Help for Veterans With Depression in Primary Care
SOS-Depression
2 other identifiers
interventional
400
1 country
2
Brief Summary
Depression is disabling and affects one in five Veterans. VA's Primary Care-Mental health Integration (PCMHI) enables specialists to support medication treatment in primary care, but timely and sufficient access to psychotherapy is unattainable despite Veteran preference for psychotherapy. This study aims to close the gap in psychotherapy access for VA primary care patients with depression by adapting PCMHI collaborative care models to improve uptake of peer-supported computerized cognitive behavioral therapy (cCBT).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable depression
Started Sep 2026
Typical duration for not_applicable depression
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 19, 2026
CompletedFirst Posted
Study publicly available on registry
August 24, 2026
CompletedStudy Start
First participant enrolled
September 1, 2026
ExpectedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2029
Study Completion
Last participant's last visit for all outcomes
August 1, 2029
August 24, 2026
August 1, 2026
2.5 years
August 19, 2026
August 19, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Patient Health Questionnaire (PHQ-9)
The Patient Health Questionnaire (PHQ-9) is a scale commonly used to measure and categorize depression symptoms. It is already administered as part of routine primary care at our study site. The minimum score is 0, the maximum is 27. A higher score indicates a worse outcome (i.e. more severe depression symptoms).
3- and 6-month follow up
Secondary Outcomes (3)
Behavioral Activation for Depression Scale (BADS-SF)
3- and 6-month follow up
Generalized Anxiety Disorder (GAD-7)
3- and 6-month follow up
World Health Organization Disability Assessment Schedule (WHODAS 2.0)
3- and 6-month follow up
Other Outcomes (1)
Treatment Engagement
6-months
Study Arms (2)
Enhanced Usual Care (EUC)
ACTIVE COMPARATORParticipants in the enhanced usual care arm will receive access to computerized cognitive behavioral therapy (cCBT) supported by a care manager in addition to the usual care provided.
Supported Online Self-help for Depression (SOS-Depression)
EXPERIMENTALParticipants in the intervention arm will receive computerized cognitive behavioral therapy (cCBT) supported by a care manager and a designated Peer support specialist in addition to the usual care provided.
Interventions
Enhanced usual care includes all the usual depression care at the VA and access to an online therapy program with no peer support sessions. The online therapy program offered consists of several modules for depression care, specifically tailored for Veterans.
Supported Online Self-help for Depression (SOS-Depression) includes all the usual depression care at the VA and access to an online therapy program with support sessions with a peer. The online therapy program consists of several modules for depression care, specifically tailored for Veterans.
Eligibility Criteria
You may qualify if:
- Must be enrolled in the VHA and currently receiving primary care services at VA Los Angeles or San Diego
- Have access to computer (mobile or desktop), internet, telephone, and email
- Able to read English text on a computer screen
- Score 10 or higher on the PHQ-9
You may not qualify if:
- Have moderate-high suicide risk (e.g. suicide flag) or active suicidality
- Have other serious mental illness (e.g. bipolar disorder, psychosis)
- Have medical disorder that would prevent/ interfere with participation (e.g. dementia/cognitive impairment, terminal illness)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
VA San Diego Healthcare System
San Diego, California, 92161, United States
VA Greater Los Angeles Healthcare System
West Los Angeles, California, 90073-1003, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- HEALTH SERVICES RESEARCH
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor of Medicine and Psychiatry
Study Record Dates
First Submitted
August 19, 2026
First Posted
August 24, 2026
Study Start (Estimated)
September 1, 2026
Primary Completion (Estimated)
March 1, 2029
Study Completion (Estimated)
August 1, 2029
Last Updated
August 24, 2026
Record last verified: 2026-08
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP
- Time Frame
- In accordance with NDA guidelines, we will complete the Collections' Data Expected section within six months of the grant award. Thereafter we will submit data every 6 months in accordance with the NDA Data Sharing Terms and Conditions Post-Award Milestones.
- Access Criteria
- UCLA is committed to the ideals of collaborative research, and as such, will adhere to the sponsors Grant Policy on Sharing of Unique Research Resources. The data collected for this research represent a valuable resource to the scientific community, and we will undertake all reasonable procedures to make them accessible to others, while respecting the special needs for confidentiality. The data collected during this clinical trial will be made available to the research community by depositing de-identified data into the NIMH Data Archive (NDA). The NDA houses, harmonizes, and shares all human-subjects data collected as part of NIMH-funded projects with the goal of accelerating progress in the research of mental health. NDA is one database infrastructure that supports efforts to make data collected by different laboratories as consistent as possible and allow other researchers to access those data for secondary use. NDA stores and shares clinical/phenotypic, imaging, genomic, and othe
The data collected during this clinical trial will be made available to the research community by depositing de-identified data into the NIMH Data Archive (NDA). All of the NIMH Common Data Elements (CDEs) will be collected for this study, following the NIMH expectations. In addition to the CDEs required by the NDA, we will also submit data elements covering demographics and health outcomes, healthcare services use, and satisfaction. We will use NIH-endorsed CDEs when possible. * Sex * Marital status * Ethnicity * Race * Level of education * Work status * Housing status * Behavioral Activation for Depression Scale (BADS-SF) * Alcohol Use Disorders Identification Test (AUDIT-C) * Columbia-Suicide Severity Rating Scale (C-SSRS) * Posttraumatic Stress Disorder (PTSD) Checklist for DSM-5 * Client Satisfaction Questionnaire (CSQ-I) * System Usability Scale (SUS)