Characterization and Validation of the Short Physical Performance Battery in Individuals Diagnosed With Parkinson's Disease

NCT07780461 | Recruiting

• 1 other identifier: PDSPPB
• Study Type: observational
• Target: 350
• Locations: 1 country
• Sites: 2

Brief Summary

Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with motor and non-motor impairments that affect physical function, mobility, balance, and quality of life. Although Galicia is one of the Spanish regions with a high prevalence of PD, comprehensive information regarding the functional characteristics of this population remains limited. This observational cross-sectional study aims to characterize the sociodemographic, clinical, cognitive, behavioral, and functional profile of individuals with Parkinson's disease in Galicia and to evaluate the validity and reliability of the Short Physical Performance Battery (SPPB) in this population. The findings will provide updated information on the functional status of people with PD in Galicia and support the use of the SPPB as a practical tool for the assessment of physical performance in clinical and research settings.

Conditions

PARKINSON DISEASE (Disorder)

Keywords

Parkinson´s Disease; Physical Function; Short Physical Performance Battery (SPPB); Functional Assessment; Psychometric Validation

Outcome Measures

Primary Outcomes (4)

• Test-Retest Reliability of the SPPB

  Reliability of the SPPB assessed through repeated administration after a minimum interval of one week using the Intraclass Correlation Coefficient (ICC).

  Baseline and 1 week

• Short Physical Performance Battery (SPPB) Total Score

  Evaluation of lower-extremity physical performance through balance, gait speed, and chair-rise tasks. Total score ranges from 0 to 12, with higher scores indicating better physical performance.

  Baseline

• Internal Consistency of the SPPB

  Internal consistency of the three SPPB components assessed using Cronbach's alpha coefficient.

  Baseline

• Convergent Construct Validity of the SPPB

  Correlation of SPPB scores with established functional assessment measures (TUG, BBS, and MDS-UPDRS Part III).

  Baseline

Secondary Outcomes (8)

• Ad Hoc Sociodemographic and Clinical Data Collection Form

  Baseline

• Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) (Goetz et al., 2008)

  Baseline

• International Physical Activity Questionnaire (IPAQ)

  Baseline

• Mini-Mental State Examination (MMSE) (Folstein et al., 1975; Spanish validation: Lobo et al., 1999)

  Baseline

• Handgrip Strength Assessment

  Baseline

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Individuals with a diagnosis of Parkinson's disease

You may qualify if:

• Clinical diagnosis of Parkinson's disease confirmed by a neurologist.
• Provision of written informed consent by the participant or, when applicable, by a legally authorized representative.

You may not qualify if:

• Inability to complete the study assessment procedures.

Sponsors & Collaborators

• University of Vigo: lead

Study Sites (2)

Asociación de Parkinson de la Provincia de Pontevedra

Pontevedra, Pontevedra, 36005, Spain

RECRUITING

Facultad de Fisioterapia

Pontevedra, Pontevedra, 36005, Spain

RECRUITING

Related Publications (11)

• Motl RW, Learmonth YC, Wojcicki TR, Fanning J, Hubbard EA, Kinnett-Hopkins D, Roberts SA, McAuley E. Preliminary validation of the short physical performance battery in older adults with multiple sclerosis: secondary data analysis. BMC Geriatr. 2015 Dec 3;15:157. doi: 10.1186/s12877-015-0156-3.

  PMID: 26630923 BACKGROUND

• Lopez-Liria R, Vega-Tirado S, Valverde-Martinez MA, Calvache-Mateo A, Martinez-Martinez AM, Rocamora-Perez P. Efficacy of Specific Trunk Exercises in the Balance Dysfunction of Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis. Sensors (Basel). 2023 Feb 6;23(4):1817. doi: 10.3390/s23041817.

  PMID: 36850413 BACKGROUND

• Leddy AL, Crowner BE, Earhart GM. Functional gait assessment and balance evaluation system test: reliability, validity, sensitivity, and specificity for identifying individuals with Parkinson disease who fall. Phys Ther. 2011 Jan;91(1):102-13. doi: 10.2522/ptj.20100113. Epub 2010 Nov 11.

  PMID: 21071506 BACKGROUND

• Kim Y, Park I, Kang M. Convergent validity of the international physical activity questionnaire (IPAQ): meta-analysis. Public Health Nutr. 2013 Mar;16(3):440-52. doi: 10.1017/S1368980012002996. Epub 2012 Jul 2.

  PMID: 22874087 BACKGROUND

• Kegelmeyer DA, Kloos AD, Thomas KM, Kostyk SK. Reliability and validity of the Tinetti Mobility Test for individuals with Parkinson disease. Phys Ther. 2007 Oct;87(10):1369-78. doi: 10.2522/ptj.20070007. Epub 2007 Aug 7.

  PMID: 17684089 BACKGROUND

• Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994 Mar;49(2):M85-94. doi: 10.1093/geronj/49.2.m85.

  PMID: 8126356 BACKGROUND

• Brusse KJ, Zimdars S, Zalewski KR, Steffen TM. Testing functional performance in people with Parkinson disease. Phys Ther. 2005 Feb;85(2):134-41.

  PMID: 15679464 BACKGROUND

• Bennie, S., Bruner, K., Dizon, A., Fritz, H., Goodman, B., & Peterson, S. (2003). Measurements of Balance: Comparison of the Timed "Up and Go" Test and Functional Reach Test with the Berg Balance Scale. Journal Of Physical Therapy Science, 15(2), 93-97. https://doi.org/10.1589/jpts.15.93

  BACKGROUND

• Temporiti F, Mandaresu S, Calcagno A, Coelli S, Bianchi AM, Gatti R, Galli M. Kinematic evaluation and reliability assessment of the Nine Hole Peg Test for manual dexterity. J Hand Ther. 2023 Jul-Sep;36(3):560-567. doi: 10.1016/j.jht.2022.01.007. Epub 2022 Feb 26.

  PMID: 35232627 BACKGROUND

• Morris ME, Martin CL, Schenkman ML. Striding out with Parkinson disease: evidence-based physical therapy for gait disorders. Phys Ther. 2010 Feb;90(2):280-8. doi: 10.2522/ptj.20090091. Epub 2009 Dec 18.

  PMID: 20022998 BACKGROUND

• Martinez-Martin P, Rodriguez-Blazquez C, Alvarez-Sanchez M, Arakaki T, Bergareche-Yarza A, Chade A, Garretto N, Gershanik O, Kurtis MM, Martinez-Castrillo JC, Mendoza-Rodriguez A, Moore HP, Rodriguez-Violante M, Singer C, Tilley BC, Huang J, Stebbins GT, Goetz CG. Expanded and independent validation of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). J Neurol. 2013 Jan;260(1):228-36. doi: 10.1007/s00415-012-6624-1. Epub 2012 Aug 5.

  PMID: 22865238 BACKGROUND

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Irimia Mollinedo-Cardalda, PT, PhD

  Universidade de Vigo

  PRINCIPAL INVESTIGATOR

• Iris Machado de Oliveira, PT, PhD

  Universidade de Vigo

  STUDY CHAIR

• Diego Férnandez-Vázquez, PT, PhD

  Univeridad Rey Juan Carlos

  STUDY CHAIR

• Esther Monge-Pereira, PT, PhD

  Universidade de Vigo

  STUDY CHAIR

Central Study Contacts

Irimia Mollinedo-Cardalda, PT, PhD

CONTACT

+34986801771; imollinedo@uvigo.es

Esther Monge-Pereira, PT, PhD

CONTACT

+34986801750; esther.monge@uvigo.es

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Week
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Permanent Lecturer in Physiotherapy

Study Record Dates

• First Submitted: August 3, 2026
• First Posted: August 21, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): November 25, 2026
• Study Completion (Estimated): December 25, 2026
• Last Updated: August 25, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

ES (2)