Evaluation of the Effect of Different Irrigation Activation Methods During Endodontic Retreatment

NCT07779148 | Recruiting DMC

• 1 other identifier: Endodontic Retreatment
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

The persistent and secondary intraradicular infections are the primary causes of post-treatment disease following endodontic treatment of any tooth. When conventional root canal treatment fails, endodontic retreatment is often the preferred option, as it represents one of the most conservative approaches. Endodontic retreatment involves removing old root canal filling material followed by cleaning, shaping, and refilling the canals. It may be associated with postoperative pain due to periapical tissue irritation and apical extrusion of debris during instrumentation.

Conditions

Endodontic Inflammation

Outcome Measures

Primary Outcomes (1)

• Post Operative Pain

  Assessing the post operative pain measured by a numerical pain rating scale (NRS) where the level of pain will be recorded as follows: 0 reading represents "no pain" ; 1- 3 reading represents "mild pain" ; 4- 6 reading represents "moderate pain" and 7- 10 reading representative sever pain.

  from 6 hours to 48 hours after the procedure

Study Arms (2)

Xp Finisher R file Group

ACTIVE COMPARATOR

About 17 cases suffering from caries then the Caries will be removed with a sterile stone will undergo Xp Shaper R file for irrigation activation during retreatment procedure

Procedure: Xp Finisher R file

Ultrasonic activation Group

ACTIVE COMPARATOR

About 17 cases suffering from caries then the Caries will be removed with a sterile stone will undergo Ultrasonic activation of irrigation activation during retreatment procedure

Procedure: Xp Finisher R file

Interventions

Xp Finisher R file PROCEDURE

to evaluate the incidence and severity of postoperative pain using a numeric rating scale at 24, 48, and 72 hours and periapical healing via CBCT following retreatment with two different irrigation activation techniques: 1. Xp Finisher R file activation of irrigation. 2. Ultrasonic activation of irrigation.

Also known as: Ultrasonic activation

Ultrasonic activation Group; Xp Finisher R file Group

Eligibility Criteria

• Age: 13 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Patients with mature teeth.
• Patients with failed previous Endo treatment related by periapical periodontitis
• Single Rooted with single root canal.
• Patients should be free from any systemic disease that may affect predictable outcome.
• Patients who agree to the consent and will commit to follow-up period

You may not qualify if:

• Patients with immature roots.
• Patients with any systemic disease that may affect normal healing.
• Patients with swelling.
• Pregnant females.
• Patients who could/would not participate in follow-up.
• Patients with old age.
• Teeth with periodontal involvement.
• Teeth with vertical root fractures.
• Non-restorable teeth

Sponsors & Collaborators

• Minia University: lead

Study Sites (1)

Dentistery Hospital, Minia University

Minya, Egypt

RECRUITING

MeSH Terms

Conditions

Pulpitis

Condition Hierarchy (Ancestors)

Dental Pulp Diseases; Tooth Diseases; Stomatognathic Diseases

Study Officials

• Wael Hussien kamel, M.D

  Professor of Endodontics Head of Endodontic Department,Faculty of Dentistry,Future University

  STUDY CHAIR

Central Study Contacts

Magdy Mohy Eldeen Abdulrazzak, MSC

CONTACT

+201153661666; Dentist.magdy@gmail.com

Wael Hussien kamel, professor

CONTACT

+201001251094; waelkamel.26@azhar.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer at Endodontics Department, Faculty of Dentistry

Study Record Dates

• First Submitted: August 18, 2026
• First Posted: August 21, 2026
• Study Start: August 1, 2026
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): August 10, 2027
• Last Updated: August 21, 2026

Record last verified: 2026-08

Locations

EG (1)