The Shengjing Lung Cancer Cohort (SJ-LCC) Study on Risk Factors for Disease Development and Progression

NCT07779005 | Recruiting

• 1 other identifier: 2020PS556K
• Study Type: observational
• Target: 1,500
• Locations: 1 country
• Sites: 1

Brief Summary

Modifiable risk factors, including smoking, alcohol consumption, and diet, play critical roles in cancer progression and patient prognosis. In patients diagnosed with lung cancer, these risk factors not only directly modulate host metabolism and immune regulation, but also exert indirect effects by altering the internal milieu, such as the gut microbiota-potentially exerting a profound impact on long-term clinical trajectories. Leveraging a well-characterized, longitudinally followed cohort of confirmed lung cancer patients, this study systematically assesses habitual dietary intake, emotional well-being, lifestyle behaviors, and related variables using validated instruments, including the Food Frequency Questionnaire (FFQ). Furthermore, the study integrates multidimensional biomarker profiling across tumor tissue, blood, urine, and fecal samples. By linking exposure profiles, multi-omics data, and long-term clinical follow-up records, this project aims to:

1. 1.Evaluate Prognostic Associations: Investigate the relationships between exposure profiles (e.g., dietary patterns) and long-term clinical outcomes in lung cancer patients, including progression-free survival (PFS), overall survival (OS), and recurrence risk.
2. 2.Elucidate Biological Mechanisms: Unravel the underlying mechanisms by which the "exposure profile-multi-omics" axis mediates lung cancer progression, and identify candidate biomarkers with predictive value for clinical prognosis.

Conditions

Lung Caner

Outcome Measures

Primary Outcomes (2)

• 6-Month Progression-Free Survival (PFS) Rate

  6 months

• Overall Survival (OS)

  From enrollment through study completion, up to 10 years

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Starting in February 2019, patients with histologically or cytologically confirmed lung cancer who received treatment and follow-up at Shengjing Hospital of China Medical University were enrolled in this study. Clinical and demographic characteristics were extracted from the electronic medical record (EMR) system, lifestyle habits and related exposure data were collected using a validated Food Frequency Questionnaire (FFQ), and high-quality follow-up was conducted on a regular basis.

You may qualify if:

• Patients aged between 18 and 75 years;
• Patients with newly, pathologically confirmed lung cancer;
• Patients diagnosed within the preceding 6 months (time since confirmed diagnosis \< 6 months).

You may not qualify if:

• Individuals aged outside the range of 18-75 years, or those in poor general physical condition who are unable to cooperate with the questionnaire survey;
• Patients with non-primary lung cancer, non-newly diagnosed lung cancer, or those unable to provide definitive pathological confirmation;
• Individuals with severe depression, pregnant women, or those diagnosed with severe cardiovascular/cerebrovascular diseases or severe metabolic dysfunctions affecting the liver, kidneys, or other major organs;
• Individuals unwilling to participate in the study.

Sponsors & Collaborators

• Shengjing Hospital: lead

Study Sites (1)

Shengjing Hospital affiliated to China Medical University

Shenyang, Liaoning, 110000, China

RECRUITING

Central Study Contacts

Huanhuan Chen Dr.Chen

CONTACT

+86 18940255489; 20152214@cmu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Shengjing Hospital of China Medical University

Study Record Dates

• First Submitted: August 19, 2026
• First Posted: August 21, 2026
• Study Start: February 1, 2019
• Primary Completion: December 30, 2024
• Study Completion (Estimated): December 31, 2029
• Last Updated: August 21, 2026

Record last verified: 2026-06

Locations

CN (1)