NCT07778706|Not Yet Recruiting
Intervention on Mathematical Problem-Solving Skills
Interventions in Math Learning Disabilities: Cognitive and Neural Correlates
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Interventions in Math Learning Disabilities: Cognitive and Neural Correlates
Sponsor study identifier
Secondary identifiers
NIH
interventional
160
1 country
1
Study Start
September 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
September 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
September 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing and remediating weaknesses in arithmetic skills in children, including those with mathematical learning disabilities.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 18, 2026
Actual (reported)August 21, 2026
Actual (reported)September 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
September 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
September 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Change from baseline in arithmetic task performance (reaction time)
Performance will be measured by children's reaction time (milliseconds) on arithmetic task
Baseline and post-intervention (after 6 weeks)
Change from baseline in arithmetic task performance (accuracy)
Performance will be measured by children's accuracy (% trials correct) on arithmetic task
Baseline and post-intervention (after 6 weeks)
Change from baseline in latent cognitive measures of arithmetic task performance (drift rate)
Latent cognitive processing will be measured by drift rate from children's arithmetic task performance
Baseline and post-intervention (after 6 weeks)
Participants complete 6 weeks of activities, 1-hour hybrid sessions daily for 3 days per week (in total 18 sessions), that progressively develop the efficient use of arithmetic problem-solving strategies. Before and after training, participants complete arithmetic problem-solving tasks during neuroimaging sessions.
Participants complete 6 weeks of activities, 1-hour hybrid sessions daily for 3 days per week (in total 18 sessions), that focus solely on enhancing arithmetic fluency. Before and after training, participants complete arithmetic problem-solving tasks during neuroimaging sessions.
Speeded practice training includes activities that focus solely on enhancing arithmetic fluency.
Arithmetic strategy training includes activities that progressively develop the efficient use of arithmetic problem-solving strategies.
Stanford University
Palo Alto, California, 94304, United States
Vinod Menon, Ph.D.
Stanford University
First Submitted
August 18, 2026
First Posted
August 21, 2026
Study Start
September 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
September 2031
Embracing Morning BReakfast and Activity for Classroom Engagement
Change from baseline in latent cognitive measures of arithmetic performance (post-error adjustment)
Latent cognitive processing will be measured by post-error adjustment from children's arithmetic task performance
Baseline and post-intervention (after 6 weeks)
Change from baseline in brain activation during arithmetic task performance
Neural activity will be measured during a functional magnetic resonance imaging arithmetic task. Data will consist of beta values from individual-subject contrast maps for the Small vs. Large contrast in the whole-brain general linear modeling functional magnetic resonance imaging analysis.
Baseline and post-intervention (after 6 weeks)
Change from baseline in brain representation during arithmetic task performance
Neural activity will be measured during the functional magnetic resonance imaging arithmetic task. Data will consist of spatial correlations of voxel-wise brain activation between Trained vs. Rest and Untrained vs. Rest contrasts for individual subjects.
Baseline and post-intervention (after 6 weeks)
Change from baseline in brain connectivity during arithmetic task performance
Neural activity will be measured during the functional magnetic resonance imaging arithmetic task. Data will consist of generalized psychophysiological interaction beta values from individual subject contrast maps for Small vs. Large contrast.
Baseline and post-intervention (after 6 weeks)
Change from baseline in untrained arithmetic task performance (reaction time)
Baseline and post-intervention (after 6 weeks)
Change from baseline in untrained arithmetic task performance (accuracy)
Baseline and post-intervention (after 6 weeks)
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Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
September 2031
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
August 24, 2026
Record last verified: 2026-08
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