The Impact of Left Stellate Ganglion Block on Systemic Inflammation and Neuromodulation in CABG Surgery.

NCT07776496 | Not Yet Recruiting DMC

• 1 other identifier: Lt SGB in CABG
• Study Type: interventional
• Target: 81
• Locations: 0 countries
• Sites: N/A

Brief Summary

((82)) patients scheduled to undergo elective CABG by the same surgical team will be allocated randomly by computer-generated random numbers into two equal groups (n= 41). Study groups: Group S (Stellate Ganglion Block Group): Patients will receive an ultrasound-guided Left stellate ganglion block prior to induction of general anesthesia. The block will be performed at the C6 level under strict aseptic precautions using 5 mL of 0.25% bupivacaine. Successful blockade will be confirmed by the appearance of ipsilateral Horner's syndrome. Group C (Control Group): Patients will receive standard perioperative care without stellate ganglion block and will undergo the same anesthetic and surgical management protocol as Group S.

Conditions

Delirium - Postoperative; Inflammation Biomarkers; Stellate Ganglion Block; CABG

Keywords

postoperative Delirium; stellate ganglion block; SGB; IL6; Inflammatory biomarkers

Outcome Measures

Primary Outcomes (1)

• Interleukin 6 (IL-6) level in pg/ml change from baseline

  0 (baseline) and 6 hours after cardiopulmonary bypass

Secondary Outcomes (9)

• 1. Incidence of postoperative delirium

  day 0 to 3 days after successful extubation

• 2. Delirium severity will be assessed using the Delirium Rating Scale-Revised-98.

  day 0 to 3 days after successful extubation

• 3. CRP in mg/L, neutrophil to lymphocyte ratio (NLR) and Platelet to white cell ratio (PWR).

  day 0 (baseline) to day 3

• 4. Creatinine baseline level in mg/dl, 24 h postoperatively, 48 h postoperatively, and the urine output was recorded on the first and second postoperative days.

  0 (baseline) to 48 hours postoperative

• 6. Total intraoperative opioid consumption

  0 hour From induction of anesthesia to 5 hours after induction of anesthesia

Study Arms (2)

stellate ganglion block

EXPERIMENTAL

Group S (Stellate Ganglion Block Group): Patients will receive an ultrasound-guided Left stellate ganglion block prior to induction of general anesthesia. The block will be performed at the C6 level under strict aseptic precautions using 5 mL of 0.25% bupivacaine. Successful blockade will be confirmed by the appearance of ipsilateral Horner's syndrome.

Procedure: Stellate Ganglion Block

control

NO INTERVENTION

Group C (Control Group): Patients will receive standard perioperative care without stellate ganglion block and will undergo the same anesthetic and surgical management protocol as Group S.

Interventions

Stellate Ganglion Block PROCEDURE

ultrasound guided left stellate ganglion block in patients undergoing CABG surgery to compare with control group which not receive any block even SHAM block and show its effect on reducing inflammatory biomarkers especially il6 and its effect in reducing postoperative delirium

stellate ganglion block

Eligibility Criteria

• Age: 65 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• All elderly (≥65 years) patients of both genders, as according to the World Health Organization, the chronologic age of 65 years was accepted by most developed countries in the world as a definition of "elderly" or older person. Patients scheduled for elective cardiac surgery under general anesthesia.14
• American Society of Anesthesiologists (ASA) physical status class II or III.
• Patients will be stratified according to their baseline surgical risk utilizing the EuroSCORE II tool \>4%15.
• American Society of Anesthesiologists (ASA) physical status class II or III.

You may not qualify if:

• Pre-existing dementia or significant cognitive impairment.
• History of stroke or cerebrovascular disease.
• Contraindications to SGB (e.g., coagulopathy, local infection, or anatomical abnormalities).
• Preoperative use of antipsychotics or antidepressants.
• Sinus bradycardia \<50bpm \&complete heart block
• BMI\>35
• Redo or emergency surgery.
• On preoperative mechanical ventilation and long sedation time.
• Low EF patients \<35%.

Sponsors & Collaborators

• OMAR ABDELAZIZ ABOELFADL: lead

MeSH Terms

Conditions

Emergence Delirium

Condition Hierarchy (Ancestors)

Delirium; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

omar abulfadl abulfadl, assistant lecturer

CONTACT

+201069909234; omarabulfadl1@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: assistant lecturer of anaesthesiology, intensive care and pain management, faculty of medicine, assiut university

Study Record Dates

• First Submitted: July 30, 2026
• First Posted: August 20, 2026
• Study Start (Estimated): December 1, 2026
• Primary Completion (Estimated): March 1, 2028
• Study Completion (Estimated): August 1, 2028
• Last Updated: August 20, 2026

Record last verified: 2026-08