Otago Exercise Program in Chemotherapy Induced Peripheral Neuropathy

NCT07773922 | Completed

• 1 other identifier: OTAGO-CIPN-P.T.REC/012/006339
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Forty-eight participants between the age of 35 to 55years patient treated with Taxane chemotherapy, will be randomly divided into two equal groups, each comprising 24 patients.

• Group (A): Consists of twenty- four patients have chemo therapy Induced peripheral Neuropathy and will receive Otago exercise plus resistance exercise 3times per week for 8weeks
• Group (B): Consists of twenty- four patients with Chemotherapy induced peripheral Neuropathy who will receive conventional physical therapy program including: resistance exercise for 8weeks , 3 times per week.

Conditions

Chemotherapy-induced Peripheral Neuropathy (CIPN)

Keywords

Otago Exercise Program; Chemotherapy-Induced Peripheral Neuropathy (CIPN); Muscle Weakness; Muscle Strength; Cancer Survivors; Exercise Therapy; Rehabilitation

Outcome Measures

Primary Outcomes (1)

• Muscle strength of the lower limb muscles will be assessed using a Hand-Held Dynamometer (HHD).

  Muscle strength of the lower limb muscles will be assessed using a Hand-Held Dynamometer (HHD).

  Baseline and after 8 weeks

Secondary Outcomes (1)

• Modified Total Neuropathy Score (mTNS)

  Baseline and after 8 weeks

Study Arms (2)

Otago Exercise Plus Resistance Exercise

EXPERIMENTAL

Participants will receive the Otago Exercise Program in addition to resistance exercises using elastic bands, three sessions per week for 8 weeks.

Behavioral: Otago Exercise Program

Resistance exercises

ACTIVE COMPARATOR

Participants will receive a conventional physical therapy program including resistance exercises with elastic bands, strengthening exercises, and lower limb exercises, three sessions per week for 8 weeks.

Behavioral: Resistance Exercise

Interventions

Otago Exercise Program BEHAVIORAL

An individualized Otago Exercise Program including warm-up, lower limb strengthening, balance, walking, and flexibility exercises. The program is delivered three times per week for 8 weeks under the supervision of a physical therapist.

Otago Exercise Plus Resistance Exercise

Resistance Exercise BEHAVIORAL

resistance exercises with elastic bands, strengthening exercises, and lower limb exercises, three sessions per week for 8 weeks.

Resistance exercises

Eligibility Criteria

• Age: 35 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 35-55 years. Patients undergoing taxane chemotherapy. Diagnosed with chemotherapy-induced peripheral neuropathy (CIPN). Able to understand and follow assessment and treatment instructions. Willing to provide written informed consent.

You may not qualify if:

• Pre-existing neurological disorders (e.g., multiple sclerosis, stroke, or Parkinson's disease).
• Symptomatic heart disease, including congestive heart failure, arrhythmia, or myocardial infarction within the previous 3 months.
• Severe orthopedic conditions, fractures, or chronic debilitating diseases limiting participation in the exercise program.
• Psychological, cognitive, or emotional disorders affecting participation. Uncooperative patients or those unable to follow the exercise protocol. Refusal or inability to provide informed consent

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

1 Gamma street ,Giza, Egypt -postal code:12613

Giza, Egypt, 12613, Egypt

Location

MeSH Terms

Conditions

Muscle Weakness

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Cairo University

  faculty of physical therapy

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Physiotherapist

Study Record Dates

• First Submitted: August 15, 2026
• First Posted: August 19, 2026
• Study Start: January 1, 2026
• Primary Completion: March 1, 2026
• Study Completion: April 1, 2026
• Last Updated: August 19, 2026

Record last verified: 2026-08

Locations

EG (1)