Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

NCT07773155 | Recruiting Phase 4 FDA Drug

• 1 other identifier: IRB22-1616
• Study Type: interventional
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to learn about the effectiveness of different pain control options after hand and wrist surgery, specifically Ketorolac, Tylenol, and a regional nerve block. Ketorolac (Toradol) is a nonsteroidal anti-inflammatory drug (NSAID) that is similar to ibuprofen (Motrin or Advil). Tylenol (acetaminophen) is a commonly used over the counter drug. A nerve block is pain medication that is applied directly to the nerves around the surgical site before the surgery and keeps working to reduce pain in the area for several hours after the surgery. All of these medicines and procedures are approved by the Food and Drug Administration (FDA) for patient care. This study aims to understand if using these medicines in combination helps patients having hand and wrist surgery avoid the need for opioid pain medications.

Conditions

Surgery, Upper Extremity

Keywords

Wrist Surgery, Hand Surgery, Pain Management

Outcome Measures

Primary Outcomes (1)

• Postoperative Pain, as measured by the Numeric Pain Scale

  The numerical pain rating scale is used for rating postoperative pain. Pain scores rate from 0 to 10, with higher scores indicating more severe pain.

  2 days, 1 week and 2 weeks post op

Secondary Outcomes (1)

• Opioid requirements, measured in oral morphine equivalents

  Through 2 weeks postop

Study Arms (2)

Non-Opioid

EXPERIMENTAL

Regional Nerve Block + Ketorolac (Toradol) + Tylenol (acetaminophen)

Drug: Toradol

Opioid

ACTIVE COMPARATOR

Regional Nerve Block + Oxycodone (5mg, 10 tablets) + Tylenol (acetaminophen)

Drug: Oxycodone

Interventions

Toradol DRUG

Regional Nerve Block + Toradol + Acetaminophen

Non-Opioid

Oxycodone DRUG

Regional Nerve Block + Oxycodone + Acetaminophen

Opioid

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 years or older
• Undergoing upper extremity surgery performed by a hand and upper extremity orthopaedic surgeon at the University of Chicago.
• Undergoing procedure with regional nerve block

You may not qualify if:

• Age less than 18 years
• Concomitant chronic opioid use
• Postoperative opioid use (surgery through POD 14) for condition other than repaired fracture
• Medical contraindication to ketorolac use, including pregnancy
• Undergoing multiple concurrent surgical procedures
• Unable to communicate numerical pain score

Sponsors & Collaborators

• University of Chicago: lead

Study Sites (1)

University of Chicago

Chicago, Illinois, 60637, United States

RECRUITING

MeSH Terms

Conditions

Agnosia

Interventions

Ketorolac Tromethamine; Oxycodone

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Indomethacin; Indoles; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Codeine; Morphine Derivatives; Morphinans; Opiate Alkaloids; Alkaloids; Heterocyclic Compounds, Bridged-Ring; Heterocyclic Compounds, 4 or More Rings; Phenanthrenes; Polycyclic Aromatic Hydrocarbons; Polycyclic Compounds

Central Study Contacts

Jennifer Wolf, MD

CONTACT

773-795-3583; jwolf@bsd.uchicago.edu

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 14, 2026
• First Posted: August 19, 2026
• Study Start: March 17, 2025
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 1, 2027
• Last Updated: August 19, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)