Effect of Prophylaxis Pastes With and Without Desensitizing Agents Prior to In-office Bleaching

NCT07770373 | Not Yet Recruiting DMC

• 1 other identifier: Dental desensitizing agent
• Study Type: interventional
• Target: 38
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate the effect of prophylaxis pastes with and without desensitizing agents prior to in-office bleaching on color change and tooth sensitivity.

Conditions

Discolored Teeth

Keywords

bleaching; desensitizing agents; discoloration

Outcome Measures

Primary Outcomes (1)

• Color change

  Tooth color will be measured using the VITA Easyshade V spectrophotometer. Color measurements will be recorded in the CIE L\*, a\*, and b\* color space, and the color difference will be calculated using the CIEDE2000 color-difference formula (ΔE00).

  Baseline, Immediate after bleaching

Secondary Outcomes (1)

• Tooth sensitivity

  Baseline, Immediate after bleaching

Study Arms (2)

Prophylaxis paste with desensitizing agent

EXPERIMENTAL

Prophylaxis paste with desensitizing agent

Other: Treatment

Prophylaxis paste without desensitizing agent

PLACEBO COMPARATOR

Prophylaxis paste without desensitizing agent

Other: Treatment

Interventions

Treatment OTHER

Prophylaxis paste will be applied to all tooth surfaces using a prophy cup attached to a low-speed contra-angle handpiece. The paste will remain on the teeth for the duration specified in the manufacturer's instructions for use before being rinsed away.

Prophylaxis paste with desensitizing agent; Prophylaxis paste without desensitizing agent

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Patients who have discolored teeth, minimum of 20 natural teeth, good oral hygiene, do not have any systemic disease.

You may not qualify if:

• Patients who have extensive prosthesis or restoration, tetracycline discoloration or fluorosis, endodontically treated teeth or gingival recession, smokers, periodontal disease, pregnant or lactating.

Sponsors & Collaborators

• Cairo University: lead

MeSH Terms

Conditions

Tooth Discoloration

Interventions

Therapeutics

Condition Hierarchy (Ancestors)

Tooth Diseases; Stomatognathic Diseases

Study Officials

• Zeinab O Tolba, Associate Professor

  Cairo University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Zeinab O Tolba, Associate Professor

CONTACT

+2 01222308738; zeinab.omar@dentistry.cu.edu.eg

Possy M Abd El Aziz, Associate Professor

CONTACT

+2 01061023968; possy.moustafa@dentistry.cu.edu.eg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Conservative Dentistry Department, Faculty of Dentistry, Cairo University

Study Record Dates

• First Submitted: August 6, 2026
• First Posted: August 18, 2026
• Study Start: August 1, 2026
• Primary Completion: August 1, 2026
• Study Completion: August 1, 2026
• Last Updated: August 18, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share