Full Pulpotomy in Permanent Teeth With Irreversible Pulpitis and Apical Periodontitis

NCT07768852 | Not Yet Recruiting

• 1 other identifier: 550/226
• Study Type: interventional
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study will evaluate whether full pulpotomy can successfully treat mature permanent teeth with irreversible pulp inflammation and a periapical lesion. Full pulpotomy involves removing the inflamed pulp tissue from the crown of the tooth while preserving the healthy tissue inside the roots. The study will assess pain relief, patient satisfaction, and clinical and radiographic healing over time, including healing of the periapical lesion using dental X-rays and limited-field CBCT imaging. The findings may help determine whether full pulpotomy can provide a less invasive alternative to root canal treatment for selected teeth with periapical lesions.

Conditions

Irreversible Pulpitis With Apical Periodontitis

Keywords

Pulpitis; Periapical lesion; Pulpotomy; Laser

Outcome Measures

Primary Outcomes (1)

• Success of pulpotomy

  Treatment success will be determined by the absence of clinical signs and symptoms of disease, together with radiographic evidence of healing or reduction of the periapical lesion.

  6 and 12 months

Secondary Outcomes (1)

• Postoperative pain

  3 and 7 days after treatment

Other Outcomes (2)

• Oral health-related quality of life

  Before treatment, 1 week and 12 months after treatment

• Tooth Survival

  12, 24, and 36 months

Study Arms (1)

Pulpotomy for permanent teeth with irreversible pulpitis and apical periodontitis.

EXPERIMENTAL

Participants will receive full pulpotomy for permanent teeth with irreversible pulpitis and apical periodontitis. Treatment outcomes will be evaluated clinically and radiographically during follow-up.

Procedure: Full pulpotomy

Interventions

Full pulpotomy PROCEDURE

Full pulpotomy will be performed in permanent teeth with irreversible pulpitis and apical periodontitis, with diode laser-assisted hemostasis and calcium silicate-based pulp capping. The intervention is distinguished by the treatment of teeth with radiographic evidence of apical periodontitis using a full pulpotomy approach rather than conventional root canal treatment.

Also known as: Cervical pulpotomy, Coronal pulpotomy

Pulpotomy for permanent teeth with irreversible pulpitis and apical periodontitis.

Eligibility Criteria

• Age: 8 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Non -contributory medical history (SAI, II).
• Posterior permanent tooth (premolar, molar).
• Age range 8-30 years
• Deep caries extending into the inner quarter of dentin or exposing the pulp on the periapical radiograph
• The tooth should give positive response to cold sensibility testing
• Clinical diagnosis of symptomatic/asymptomatic irreversible pulpitis based on the symptoms, radiographic findings and results of cold testing
• The tooth is restorable, probing pocket depth and mobility are within normal limits
• Periapical radiograph demonstrates the presence of periapical lesion.

You may not qualify if:

• Non-restorable tooth.
• Signs of pulpal necrosis including sinus tract or swelling.
• Evidence of necrotic tissue in one or all canals.
• Profuse pulpal bleeding and inability to achieve hemostasis.

Sponsors & Collaborators

• King Abdullah University Hospital: lead

Related Links

• A review study published by main investigator on managemnt of teeth with carious pulp exposure with variable diagnosis and periapical status.

MeSH Terms

Conditions

Pulpitis

Condition Hierarchy (Ancestors)

Dental Pulp Diseases; Tooth Diseases; Stomatognathic Diseases

Study Officials

• Nessrin Taha, DClinDent, PhD

  Jordan University of Science and Technology

  STUDY CHAIR

Central Study Contacts

Nessrin Taha, DclinDent (Endo), PhD

CONTACT

+962776566110; n.taha@just.edu.jo

Nessrin Taha, PhD

CONTACT

+962777258907; nessrin_taha@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: This is a single-arm, prospective clinical study. All eligible participants will receive the same full pulpotomy treatment protocol, including diode-laser-assisted hemostasis and calcium silicate-based pulp capping. Treatment outcomes will be evaluated clinically and radiographically during follow-up. There is no randomization or concurrent control group.

Study Record Dates

• First Submitted: August 8, 2026
• First Posted: August 17, 2026
• Study Start (Estimated): October 7, 2026
• Primary Completion (Estimated): October 1, 2028
• Study Completion (Estimated): October 1, 2030
• Last Updated: August 17, 2026

Record last verified: 2026-08