NCT07766720

Brief Summary

Eggshell membrane and Curcumin supplementation prior to intense exercise may reduce inflammation, muscle and joint pain, and promote recovery. This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients affects recovery from intense exercise.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
5mo left

Started Feb 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress59%
Feb 2026Dec 2026

Study Start

First participant enrolled

February 1, 2026

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

July 30, 2026

Completed
15 days until next milestone

First Posted

Study publicly available on registry

August 14, 2026

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 15, 2026

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2026

Last Updated

August 14, 2026

Status Verified

August 1, 2026

Enrollment Period

9 months

First QC Date

July 30, 2026

Last Update Submit

August 10, 2026

Conditions

Exercise-induced Muscle SorenessExercise-induced Joint PainExercise-induced Joint StiffnessExercise-induced Cartilage Turnover

Keywords

intense exerciseNEMcurQ+eggshell membranecurcumin

Outcome Measures

Primary Outcomes (1)

  • VAS Muscle Soreness Rating

    Changes in Visual Analog Scale (VAS) ratings of muscle soreness (rated from zero to 100 mm) from baseline following intense exercise. The higher the rating, the more muscle soreness so negative changes in VAS would equate to improvement.

    2 weeks

Secondary Outcomes (4)

  • Urinary CTX-II

    2 weeks

  • Muscle Damage

    2 weeks

  • Exercise Performance

    2 weeks

  • Inflammation Biomarkers

    2 weeks

Study Arms (4)

Active, EM

EXPERIMENTAL

500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule.

Dietary Supplement: NEM® brand eggshell membrane powderDietary Supplement: Curc Placebo

Active, curc

EXPERIMENTAL

2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.

Dietary Supplement: curQ+® brand highly absorbable curcuminDietary Supplement: EM Placebo

Placebo

PLACEBO COMPARATOR

500 mg/day of psyllium husk fiber powder in a single #0 capsule PLUS 2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.

Dietary Supplement: EM PlaceboDietary Supplement: Curc Placebo

Active, EM+Curc

EXPERIMENTAL

500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule PLUS 2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.

Dietary Supplement: NEM® plus curQ+® combination

Interventions

NEM® brand eggshell membrane powderDIETARY_SUPPLEMENT

500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule.

Active, EM
curQ+® brand highly absorbable curcuminDIETARY_SUPPLEMENT

2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.

Active, curc
EM PlaceboDIETARY_SUPPLEMENT

500 mg/day of psyllium husk fiber powder in a single #0 capsule.

Active, curcPlacebo
Curc PlaceboDIETARY_SUPPLEMENT

2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.

Active, EMPlacebo
NEM® plus curQ+® combinationDIETARY_SUPPLEMENT

500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule PLUS 2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.

Active, EM+Curc

Eligibility Criteria

Age18 Years - 40 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Age 18 to 40 at the time of consent.
  • Healthy and recreationally active.
  • Ability to comply with study procedures.
  • Agree to refrain from alcohol intake and use of non-steroidal anti-inflammatory (NSAIDS), aspirin, and other over-the-counter pain medications for 48 hours prior to and after completion of each testing session.

You may not qualify if:

  • No recent history of exercise training
  • An orthopedic limitation that would prevent the ability to perform the exercise intervention.
  • Participants who currently smoke cigarettes.
  • Known allergies to eggs, sulfur, or curcumin.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Exercise & Sport Nutrition Lab - Texas A&M University

College Station, Texas, 77843, United States

RECRUITING

Study Officials

  • Richard B. Kreider, Ph.D.

    Exercise & Sport Nutrition Lab, Texas A&M University

    PRINCIPAL INVESTIGATOR

  • Kevin J. Ruff, Ph.D.

    ESM Technologies, LLC

    STUDY DIRECTOR

Central Study Contacts

Richard B. Kreider, Ph.D.

CONTACT

(979) 458-1498rbkreider@tamu.edu

Christopher Rasmussen, M.S.

CONTACT

(979) 458-1498crasmussen@tamu.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: Single-Dummy, Placebo-controlled, Parallel-Group
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 30, 2026

First Posted

August 14, 2026

Study Start

February 1, 2026

Primary Completion (Estimated)

October 15, 2026

Study Completion (Estimated)

December 31, 2026

Last Updated

August 14, 2026

Record last verified: 2026-08

Data Sharing

IPD Sharing
Will not share

Locations

US(1)