Long-term Medical Impact of War Injuries on Military Personnel

NCT07766447 | Not Yet Recruiting

• 2 other identifiers: 2024PBMD012025-A02095-44
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

Beyond short-term multidisciplinary care, the French Armed Forces Health Service provides medical and surgical care, followed by medical and social care and long-term support for the wounded, especially when they have suffered multiple injuries during operations and are severely disabled. This involves primary phases of rehabilitation to limit the after-effects, preserve the functional prognosis and increase the autonomy of the injured person; secondary medical and social phases of rehabilitation and reintegration to restore the injured person's place in society. The reconstruction stages are therefore essential. However, little data is available on the evolution of these patients' general health. A similar follow-up cohort was set up by the British Army to monitor physical injuries during the conflict in Afghanistan. The results suggest the possibility of long-term cardiovascular and neoplastic complications in this population. Furthermore, there is no data available on the evolution of the health status of war wounded in France. A retrospective study is currently underway, TRAUM-IMPACT RETRO, with the aim of assessing the consequences of 10 years of operational engagements from 2013 to 2023. This study should enable the medical French army service to clarify the topography of injuries and the medical and social outcomes of casualties treated at the Percy National Military Institute of Surgery (HNIA Percy) during this period. Initially, a pilot study followed by a cohort study will enable the investigators to standardise the medical follow-up of war casualties and determine their medical and social outcomes. The population studied in this clinical trial corresponds to all military personnel repatriated and treated at the Percy National Military Hospital for a war injury defined as follows: "Any physical injury of a certain degree of severity directly related to the presence of the enemy, i.e. in combat or indirectly through effective participation in war operations, preparatory to or consequential to combat. " The investigators hypothesise that severely disabled wounded soldiers are at risk of specific complications leading to excess morbidity and disability, complications associated with ageing, and a risk of social and professional isolation. As a result, the participants require lifelong monitoring to prevent, detect and manage these complications, thereby ensuring that the nation gives its wounded children the recognition the participants deserve.

Conditions

War Injury; Physical Injury

Outcome Measures

Primary Outcomes (1)

• The primary outcome is the feasibility of a standardized multidisciplinary follow-up strategy, assessed by patient recruitment rate, retention rate during follow-up, completion

  Health event reported during visits over the course of the study and type of injury at inclusion (multiple trauma, limb trauma, head trauma).

  2 years

Secondary Outcomes (9)

• Longitudinal evolution of quality of life according to type of injury

  2 years

• Longitudinal changes in gait performance

  2 yaers

• Define predictive factors for the occurrence of a new diagnosis or new treatment (psychiatric illness, chronic illness, cardiovascular disease, neoplasia, or any relevant medical event).

  2 yaers

• Level of generic pain

  2 years

• Level of anxiety and depression

  2 years

Study Arms (1)

War wounded repatriated and treated at the Percy National Institute of Military Medicine

EXPERIMENTAL

Other: biological and radiological examinations

Interventions

biological and radiological examinations OTHER

The TRAUM-IMPACT study designed to assess the feasibility of establishing a long-term cohort study to monitor war casualties and will be carried out in parallel with the usual care provided.

War wounded repatriated and treated at the Percy National Institute of Military Medicine

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 18 years
• French military patient
• Patient wounded in action
• Patient repatriated and treated at the Percy National Military Hospital for a physical war injury sustained between 2020 and 2025
• Life expectancy \> 1 year
• Patient with health insurance

You may not qualify if:

• Isolated psychological injury
• Physical injury not related to war
• Patient unable to give free consent, under guardianship or curatorship
• Refusal to participate

Sponsors & Collaborators

• Direction Centrale du Service de Santé des Armées: lead

Related Publications (4)

• Bennett AN, Dyball DM, Boos CJ, Fear NT, Schofield S, Bull AMJ, Cullinan P; ADVANCE Study. Study protocol for a prospective, longitudinal cohort study investigating the medical and psychosocial outcomes of UK combat casualties from the Afghanistan war: the ADVANCE Study. BMJ Open. 2020 Oct 30;10(10):e037850. doi: 10.1136/bmjopen-2020-037850.

  PMID: 33127630 BACKGROUND

• Hoffmann C. Blessés de guerre français en Afghanistan: de la blessure à la réinsertion [Thèse d'exercice]. [France]: Université Pierre et Marie Curie (Paris). UFR de médecine Pierre et Marie Curie; 2014.

  BACKGROUND

• Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Back M, Benetos A, Biffi A, Boavida JM, Capodanno D, Cosyns B, Crawford C, Davos CH, Desormais I, Di Angelantonio E, Franco OH, Halvorsen S, Hobbs FDR, Hollander M, Jankowska EA, Michal M, Sacco S, Sattar N, Tokgozoglu L, Tonstad S, Tsioufis KP, van Dis I, van Gelder IC, Wanner C, Williams B; ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021 Sep 7;42(34):3227-3337. doi: 10.1093/eurheartj/ehab484. No abstract available.

  PMID: 34458905 BACKGROUND

• Taylor AJ, Bindeman J, Feuerstein I, Cao F, Brazaitis M, O'Malley PG. Coronary calcium independently predicts incident premature coronary heart disease over measured cardiovascular risk factors: mean three-year outcomes in the Prospective Army Coronary Calcium (PACC) project. J Am Coll Cardiol. 2005 Sep 6;46(5):807-14. doi: 10.1016/j.jacc.2005.05.049.

  PMID: 16139129 BACKGROUND

MeSH Terms

Interventions

Biological Products

Intervention Hierarchy (Ancestors)

Complex Mixtures

Central Study Contacts

Caroline DOUTRELON, Chief Medical Officer

CONTACT

0033141466272; caroline.doutrelon@intradef.gouv.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Cohort

Study Record Dates

• First Submitted: June 4, 2026
• First Posted: August 14, 2026
• Study Start (Estimated): October 1, 2026
• Primary Completion (Estimated): December 1, 2028
• Study Completion (Estimated): December 1, 2028
• Last Updated: August 14, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share