Effects of MNRI Therapy on Fine Motor Skills in Children With Developmental Delays.

NCT07764926 | Completed DMC

• 1 other identifier: REC/RCR&AHS/25/0719
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

Developmental delay refers to a child's failure to achieve age-appropriate developmental milestones and may affect multiple developmental domains. MNRI (Masgutova Neurosensorimotor Reflex Integration) therapy is designed to improve sensory-motor integration, motor coordination, and cognitive function in children with neurodevelopmental disorders by integrating impaired reflex pathways. This randomized clinical trial will be conducted at Children Complex Hospital on 34 participants divided into experimental and control groups. The experimental group will receive MNRI therapy, while the control group will receive standard care. Reflex integration and upper limb fine motor skills will be assessed over six months, and data will be analyzed using IBM SPSS Statistics.

Conditions

MNRI; Development Delay

Keywords

Delayed Milestones, MNRI, Pediatrics,

Outcome Measures

Primary Outcomes (1)

• Change in Sollerman Hand Function Test (SHFT) total score from baseline to 4 weeks

  Fine motor function will be assessed using the Sollerman Hand Function Test (SHFT), a standardized 20-task assessment of hand function during activities of daily living. The total SHFT score ranges from 0 to 80, with higher scores indicating better hand function and manual dexterity. The primary outcome will be the change in total SHFT score from baseline to the end of the 4-week intervention.

  4 weeks

Secondary Outcomes (3)

• Change in Reflex Assessment Scale (RAS) score from baseline to 4 weeks

  4 weeks

• Change in Pediatric Evaluation of Disability Inventory (PEDI) total score from baseline to 4 weeks

  4 weeks

• Change in Participation and Sensory Environment Questionnaire (PSEQ) total score from baseline to 4 weeks

  4 weeks

Study Arms (2)

MNRI Group

EXPERIMENTAL

Masgutova Neurosensorimotor Reflex Integration (MNRI) therapy is a neurodevelopmental intervention designed to improve reflex integration, sensory-motor coordination, and fine motor functioning in children with developmental delays through structured reflex-based therapeutic exercises by using Reflex assessment scales Fine motor skill assessment of upper limbs Standardized developmental assessment tools/questionnaires Statistical analysis using IBM SPSS Statistics

Other: MNRI

control group without MNRI training

OTHER

A standardized physical treatment regimen was provided (Stretching exercise, Strengthening exercise, and facilitation of developing motor milestones) for the body. Static stretches will be given. Strengthening exercises using resistance bands or light weights

Other: Conventional Physiotherapy without MNRI

Interventions

MNRI OTHER

Participants will receive Masgutova Neurosensorimotor Reflex Integration (MNRI) therapy administered by trained physiotherapists for 45-60 minutes per session, 5 days per week, for 4 weeks. Sessions will begin with stretching and strengthening exercises, followed by reflex integration activities targeting Moro, ATNR, STNR, TLR, and Spinal Galant reflexes through exercises such as Starfish, Cat-Cow, Cross Crawl, rocking, crawling, and proprioceptive activities. Upper limb training will include hand and wrist activation, proprioceptive stimulation, gripping activities, forearm activation, and grasp pattern exercises to improve fine motor skills and reflex integration.

MNRI Group

Conventional Physiotherapy without MNRI OTHER

Participants will receive a standardized conventional physiotherapy program administered by trained physiotherapists. The program will include stretching exercises for the upper and lower limb muscles, including static stretching of tight muscle groups, strengthening exercises using resistance bands or age-appropriate light weights, facilitation and practice of age-appropriate developmental motor milestones such as rolling, sitting, crawling, standing, walking, balance, and transitional movements, as well as functional upper limb activities to improve reaching, grasping, and object manipulation. Gross motor training will be individualized according to each child's developmental level. The intervention will be provided for 45-60 minutes per session, 5 days per week for 4 weeks.

control group without MNRI training

Eligibility Criteria

• Age: 2 Years - 6 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Children of 2-6 years of age presenting with development delay.
• Severity of development delay in each domain will be labeled as mild, moderate and severe categories according to Denver Developmental Scale-II .
• Children showing signs of unintegrated primitive reflexes (e.g., Moro, ATNR, STNR, TLR, etc.), which MNRI specifically targets.

You may not qualify if:

• History of orthopedic surgery within the last half a year
• Any other neurological or musculoskeletal disorders that might hamper the study's results (e.g., traumatic brain disorders, muscular dystrophy, and epilepsy).
• Patients with autism and non-cooperative for development assessment.
• Children whose development level was above 8 years of age as Griffith scale measures development age only up to 8 years .

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Imran Amjad

Lahore, Punjab Province, 5400, Pakistan

Location

Related Publications (1)

• Stivaros S, Garg S, Tziraki M, Cai Y, Thomas O, Mellor J, Morris AA, Jim C, Szumanska-Ryt K, Parkes LM, Haroon HA, Montaldi D, Webb N, Keane J, Castellanos FX, Silva AJ, Huson S, Williams S, Gareth Evans D, Emsley R, Green J; SANTA Consortium. Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA). Mol Autism. 2018 Feb 22;9:12. doi: 10.1186/s13229-018-0190-z. eCollection 2018.

  PMID: 29484149 BACKGROUND

MeSH Terms

Conditions

Learning Disabilities; Radiation induced meningioma

Condition Hierarchy (Ancestors)

Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Sonia Babar, MS-PT

  Riphah International University, Islamabad

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Single masking (participant): Participants were blinded to group allocation. The experimental and control groups were not disclosed to the participants to minimize bias.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 27, 2026
• First Posted: August 14, 2026
• Study Start: May 11, 2026
• Primary Completion: June 27, 2026
• Study Completion: July 27, 2026
• Last Updated: August 14, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)