Sub-junctional Pinhole Technique

NCT07763223 | Completed DMC

• 1 other identifier: PRT-RCT-2026-001
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

Pinhole Regenerative Therapy (PRT) following minimally invasive non-surgical periodontal therapy (MINST) in the treatment of intrabony defects associated with Stage III Grade B periodontitis. Eligible patients with 2- or 3-wall intrabony defects will be randomly allocated to the study groups. Clinical outcomes, including probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain, together with radiographic bone defect fill assessed by periapical radiographs and CBCT, will be evaluated over a 6-month follow-up period to determine the effectiveness of the proposed minimally invasive regenerative approacا

Conditions

Periodontal Intrabony Defects; Stage III Grade B Periodontitis

Keywords

Stage III Periodontitis; Pinhole Regenerative Therapy (PRT); Periodontal Regeneration; Periodontal Therapy

Outcome Measures

Primary Outcomes (1)

• Composite Clinical Outcome

  Composite outcome of pocket closure ≤4 mm, clinical attachment level (CAL) gain ≥3 mm, and absence of bleeding on probing (BOP).

  9 months

Secondary Outcomes (4)

• Probing Pocket Depth

  Base line ( day one ), and at nine months

• Clinical Attachment Level (CAL)

  Base line ( day one ), and at nine months

• Patient Satisfaction (Postoperative Pain)

  Immediately after surgery, Day 1, Day 2, and Day 3

• Operation Chair Time

  During the Intervention

Study Arms (1)

Sub-junctional Pinhole Technique (S-PHT)

EXPERIMENTAL

Participants with Stage III periodontitis and intrabony defects received minimally invasive non-surgical periodontal therapy (MINST), followed 4 weeks later by sub-junctional pinhole technique (S-PHT), including minimally invasive defect degranulation and xenogenic bone graft placement through a facial pinhole without flap elevation

Procedure: Sub-junctional Pinhole Technique (S-PHT)

Interventions

Sub-junctional Pinhole Technique (S-PHT) PROCEDURE

Four weeks after minimally invasive non-surgical therapy (MINST), intrabony defects were accessed through a small facial pinhole. Defect degranulation was performed using minimally invasive ultrasonic and hand instruments, followed by placement of hydrated xenogenic bone graft (Geistlich Bio-Oss) through the same pinhole without flap elevation

Sub-junctional Pinhole Technique (S-PHT)

Eligibility Criteria

• Age: 39 Years - 61 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients aged 39-61 years.
• Systemically healthy patients.
• Diagnosed with Stage III periodontitis.
• Presence of probing pocket depth (PPD) ≥ 6 mm.
• Presence of clinical attachment loss (CAL) ≥ 4 mm.
• Presence of at least one 2- or 3-wall interproximal intrabony defect with:
• Defect depth ≥ 3 mm.
• Angulation width ≥ 45°.
• Each participant contributed one maxillary or mandibular single- or multi-rooted interproximal intrabony defect.

You may not qualify if:

• Patients with any systemic condition contraindicating surgical intervention.
• Pregnant or lactating females.
• Smokers.
• Alcoholic patients.
• History of periodontal therapy within the previous 6 months.
• History of antibiotic administration within the previous 6 months.
• Patients with unacceptable oral hygiene after re-evaluation following Step 1 and Step 2 periodontal therapy.
• Teeth with any degree of mobility.

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Department of Periodontology, Faculty of Dentistry, Al-Azhar University, Cairo, Egypt

Cairo, Nasr City, 11675, Egypt

Location

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Mahmoud taha eldestawy, Profesor

  Alazhar

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: No masking was used in this case series. All participants received the same intervention, and no blinding of participants or investigators was performed
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Eligible patients with Stage III Grade B periodontitis and intrabony defects will be randomly assigned to the study groups in a parallel design to evaluate minimally invasive non-surgical therapy with or without the proposed pinhole regenerative

Study Record Dates

• First Submitted: August 5, 2026
• First Posted: August 13, 2026
• Study Start: June 30, 2025
• Primary Completion: April 25, 2026
• Study Completion: June 27, 2026
• Last Updated: August 13, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)