Clinical Cohort Construction Program of Peking University Third Hospital

NCT07762144 | Enrolling By Invitation DMC

• 1 other identifier: M2022179
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiac arrest is one of the leading life-threatening emergencies, with approximately 540,000 cases occurring annually in China. Among patients who experience cardiac arrest, active cardiopulmonary resuscitation can achieve return of spontaneous circulation in 40% of cases; however, only 1-2% ultimately survive with favorable neurological outcomes. The primary contributor to mortality and morbidity is post-cardiac arrest syndrome (PCAS). PCAS represents a distinct pathophysiological process resulting from systemic ischemia/reperfusion injury, involving multiple systems and organs, and thus requires comprehensive, systematic evaluation. At present, numerous challenges remain in the field of PCAS, including the optimal targeted temperature, additional interventions that may improve neurological prognosis, post-resuscitation myocardial dysfunction and its protective strategies, characteristics and management of dysfunction in other organs, and accurate neurological prognostication after resuscitation. Therefore, in-depth research on PCAS is urgently needed to improve outcomes in cardiac arrest survivors. This study is initiated by the Department of Emergency Medicine, Peking University Third Hospital, and involves a total of six tertiary hospitals across China, constituting a multicenter investigation. The study aims to explore the effects of different targeted temperature management strategies on mortality and neurological outcomes, and to actively investigate other interventions that may ameliorate post-resuscitation brain injury, cardiac injury, and microcirculatory dysfunction, thereby reducing mortality and improving neurological prognosis in cardiac arrest patients. Furthermore, we aim to develop a neurological prediction model for cardiac arrest patients to enable accurate prognostication of neurological outcomes, which will assist emergency physicians in providing precise prognostic information to families and facilitate shared decision-making regarding subsequent treatment plans.

Conditions

Post-Cardiac Arrest Syndrome

Keywords

Cardiac Arrest

Outcome Measures

Primary Outcomes (1)

• Whether death has occurred

  Death: any death, regardless of cause (i.e., all-cause mortality)

  1 year

Secondary Outcomes (1)

• Assessment of neurological prognosis

  1year

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will enroll all eligible patients presenting to the emergency departments of the six centers who satisfy the following inclusion and exclusion criteria

You may qualify if:

• Patients who have achieved return of spontaneous circulation (ROSC) after cardiac arrest;
• With accessible intravenous or intraosseous vascular access;
• Clinical manifestations meeting any one of the following criteria: presenting with post-resuscitation brain injury, post-resuscitation cardiac dysfunction, manifestations of systemic ischemia-reperfusion injury, or other ongoing deteriorating pathological changes.

You may not qualify if:

• Patients who have not achieved return of spontaneous circulation (ROSC) after cardiac arrest;
• Patients who have declined cardiopulmonary resuscitation (CPR) (or whose legally authorized representative has refused CPR).

Sponsors & Collaborators

• Peking University Third Hospital: lead

Study Sites (1)

Emergency Dept of Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China

Location

Related Publications (5)

• Belbasis L, Bellou V. Introduction to Epidemiological Studies. Methods Mol Biol. 2018;1793:1-6. doi: 10.1007/978-1-4939-7868-7_1.

  PMID: 29876887 BACKGROUND

• Jentzer JC, Chonde MD, Dezfulian C. Myocardial Dysfunction and Shock after Cardiac Arrest. Biomed Res Int. 2015;2015:314796. doi: 10.1155/2015/314796. Epub 2015 Sep 2.

  PMID: 26421284 BACKGROUND

• Lundin A, Djarv T, Engdahl J, Hollenberg J, Nordberg P, Ravn-Fischer A, Ringh M, Rysz S, Svensson L, Herlitz J, Lundgren P. Drug therapy in cardiac arrest: a review of the literature. Eur Heart J Cardiovasc Pharmacother. 2016 Jan;2(1):54-75. doi: 10.1093/ehjcvp/pvv047. Epub 2015 Nov 26.

  PMID: 27533062 BACKGROUND

• Shao F, Li CS, Liang LR, Qin J, Ding N, Fu Y, Yang K, Zhang GQ, Zhao L, Zhao B, Zhu ZZ, Yang LP, Yu DM, Song ZJ, Yang QL. Incidence and outcome of adult in-hospital cardiac arrest in Beijing, China. Resuscitation. 2016 May;102:51-6. doi: 10.1016/j.resuscitation.2016.02.002. Epub 2016 Feb 23.

  PMID: 26924514 BACKGROUND

• Trzeciak S, Jones AE, Kilgannon JH, Milcarek B, Hunter K, Shapiro NI, Hollenberg SM, Dellinger P, Parrillo JE. Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med. 2009 Nov;37(11):2895-903; quiz 2904. doi: 10.1097/ccm.0b013e3181b01d8c.

  PMID: 19866506 BACKGROUND

MeSH Terms

Conditions

Post-Cardiac Arrest Syndrome; Heart Arrest

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Heart Diseases; Cardiovascular Diseases; Reperfusion Injury; Vascular Diseases; Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Qing bian Ma, Doctor of Medicine

  Peking University Third Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of the Emergency Department, Peking University Third Hospital

Study Record Dates

• First Submitted: June 24, 2026
• First Posted: August 13, 2026
• Study Start: January 1, 2014
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): December 31, 2030
• Last Updated: August 13, 2026

Record last verified: 2026-08

Locations

CN (1)