The Cohort Construction Project of Peking University Third Hospital

NCT07761676 | Recruiting DMC

• 2 other identifiers: BYSYDL2024010IRB00006761-M20250131
• Study Type: observational
• Target: 100,000
• Locations: 1 country
• Sites: 1

Brief Summary

The specific construction goals for this period include enrolling 100,000 individuals for dynamic follow-up, perfecting the biobank by collecting biological samples from 20,000 individuals, and gathering health questionnaire information from 30,000 people. The near-term goals emphasize the use of health check-up data combined with advanced artificial intelligence technologies to build disease prediction models and explore the association between retinal photographs and overall health status, which will assist in early screening and personalized interventions for high-risk populations. The medium- to long-term goals focus on biological age-related research, utilizing telomere length and multi-omics technologies to assess the differences between biological age and chronological age and analyze their key influencing factors. Data collection will be implemented through the health check-up centers of multiple campuses of PUTH.

Conditions

Multiple Chronic Conditions (Unspecified); Large-scale Health Examination Cohort

Keywords

Health Management; Health Check-up; Cohort Study

Outcome Measures

Primary Outcomes (11)

• Systolic and Diastolic Blood Pressure

  Blood pressure will be measured using a standardized mercury sphygmomanometer after at least 5 minutes of rest in a seated position. Both systolic blood pressure (SBP) and diastolic blood pressure (DBP) will be recorded.

  through study completion, an average of 3 year

• Fasting Lipid Profile (Total Cholesterol, Triglycerides, LDL-C, and HDL-C)

  Venous blood samples will be collected after at least 8 hours of overnight fasting. Serum levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) will be measured using an automated biochemical analyzer at the central laboratory of Peking University Third Hospital.

  through study completion, an average of 3 year

• Fasting Blood Glucose (FBG)

  Fasting venous blood samples will be collected after at least 8 hours of overnight fasting. Serum glucose levels will be measured using an automated biochemical analyzer at the central laboratory of Peking University Third Hospital.

  through study completion, an average of 3 year

• Glycated Hemoglobin (HbA1c)

  Fasting venous blood samples will be collected and analyzed using high-performance liquid chromatography (HPLC) at the central laboratory of Peking University Third Hospital. HbA1c reflects average blood glucose levels over the previous 2 to 3 months.

  through study completion, an average of 3 year

• Complete Blood Count (CBC)

  Fasting venous blood samples will be collected and analyzed using an automated hematology analyzer at the central laboratory of Peking University Third Hospital. Key parameters include white blood cell count (WBC), red blood cell count (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and platelet count (PLT).

  through study completion, an average of 3 year

• Routine Urinalysis

  Midstream clean-catch urine specimens will be collected and analyzed using an automated urine analyzer and microscopy at the central laboratory of Peking University Third Hospital. Key parameters include urine specific gravity, pH, protein, glucose, ketones, bilirubin, urobilinogen, nitrite, leukocyte esterase, and microscopic examination of red blood cells, white blood cells, and casts.

  through study completion, an average of 3 year

• Liver Function Panel

  Fasting venous blood samples will be collected and analyzed using an automated biochemical analyzer at the central laboratory of Peking University Third Hospital. Key parameters include alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin (TBIL), direct bilirubin (DBIL), total protein (TP), and albumin (ALB).

  through study completion, an average of 3 year

• Renal Function Panel

  Fasting venous blood samples will be collected and analyzed using an automated biochemical analyzer at the central laboratory of Peking University Third Hospital. Key parameters include serum creatinine (Cr), blood urea nitrogen (BUN), uric acid (UA), and estimated glomerular filtration rate (eGFR) calculated using the CKD-EPI or MDRD equation.

  through study completion, an average of 3 year

• Pulmonary Assessment

  Chest X-ray or low-dose chest CT will be performed according to standardized protocols at the Radiology Department of Peking University Third Hospital. Findings will be interpreted by certified radiologists. Results will be reported as presence or absence of pulmonary abnormalities (e.g., nodules, infiltrates, or other clinically significant findings).

  through study completion, an average of 3 year

• Abdominal Ultrasound Assessment

  Abdominal ultrasound will be performed according to standardized protocols at the Radiology Department of Peking University Third Hospital for evaluation of the liver, gallbladder, pancreas, spleen, and kidneys. Findings will be interpreted by certified radiologists. Results will be reported as presence or absence of abnormalities in each organ.

  through study completion, an average of 3 year

• Carotid Artery Ultrasound Assessment

  Carotid artery ultrasound will be performed according to standardized protocols at the Radiology Department of Peking University Third Hospital for assessment of carotid intima-media thickness (CIMT) and plaque detection. CIMT will be measured in millimeters (mm). Plaque will be reported as present or absent. All findings will be interpreted by certified radiologists.

  through study completion, an average of 3 year

Secondary Outcomes (8)

• BMI

  through study completion, an average of 3 year

• Body Fat Percentage

  through study completion, an average of 3 year

• Visceral Fat Area

  through study completion, an average of 3 year

• Skeletal Muscle Mass

  through study completion, an average of 3 year

• Handgrip Strength

  through study completion, an average of 3 year

Other Outcomes (2)

• Thyroid Function Panel

  Measured at baseline and at each annual health examination visit

• Inflammatory Biomarker Panel

  Measured at baseline and at each annual health examination visit

Study Arms (1)

Functional Community Health Examination Cohort

This cohort consists of employees from functional community units (such as government agencies, schools, and enterprises) who undergo regular health examinations at the Physical Examination Center of Peking University Third Hospital. The cohort integrates both retrospective and prospective data, with long-term follow-up and biospecimen collection (serum) stored in the hospital's biobank.

Other: observational study

Interventions

observational study OTHER

This is an observational study designed to investigate the mental health status and its influencing factors in the general physical examination population. No interventions are assigned to participants based on a protocol.

Functional Community Health Examination Cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of individuals who voluntarily undergo health examinations at the Physical Examination Center of Peking University Third Hospital. Participants are recruited from group health examination populations (including employees from functional community units such as government agencies, schools, and enterprises) who have undergone at least two consecutive health examinations at the center. The study includes both retrospective and prospective participants, with long-term follow-up and biospecimen collection (serum) stored in the hospital's biobank.

You may qualify if:

• Age ≥ 18 years. Participants must be from group health examination populations who have undergone at least two consecutive health examinations at our Physical Examination Center.

You may not qualify if:

• Failure to provide informed consent. Incomplete data, including incomplete health examination self-administered questionnaires.

Sponsors & Collaborators

• Peking University Third Hospital: lead

Study Sites (1)

Physical Examination Center, Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum specimens derived from residual blood samples of employees from functional community units who undergo regular health examinations at the Physical Examination Center of Peking University Third Hospital will be retained and stored in the Biobank of Peking University Third Hospital.

MeSH Terms

Conditions

Multiple Chronic Conditions

Interventions

Observation

Condition Hierarchy (Ancestors)

Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Officials

• Peng Wang, MMed

  Peking University Third Hospital

  STUDY DIRECTOR

Central Study Contacts

Liyuan Tao, PhD

CONTACT

+86 13581552613; tendytly@163.com

Honghai He, MPH

CONTACT

+86 15101049480; hehonghai2011@126.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 16, 2026
• First Posted: August 12, 2026
• Study Start: February 21, 2025
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: August 12, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)