High-Flow Nasal Oxygyen Therapy During Sedated Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration(EBUS-TBNA)

NCT07760727 | Not Yet Recruiting

• 1 other identifier: SBU2026-02/37
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the effects of high-flow nasal oxygen therapy on respiratory complications, blood gas parameters, and post-procedural recovery in patients undergoing sedated endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Participants will be assigned to receive either high-flow nasal oxygen therapy or conventional oxygen therapy during the procedure. The incidence of respiratory complications, blood gas changes, and recovery outcomes will be compared between the two groups.

Conditions

High Flow Oxygen Therapy; ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION; Sedation; Sedation Complication; Blood Gas Analysis

Keywords

High flow oxygen therapy,; Endobronchial Ultrasound-Transbronchial Needle Aspiration(EBUS-TBNA); Sedation; Sedation Complications; Blood Gas Analysis

Outcome Measures

Primary Outcomes (1)

• Respiratory Complications

  Incidence of respiratory complications during sedated EBUS-TBNA, including hypoxemia, oxygen desaturation, apnea, airway obstruction, and the need for airway interventions.

  During the procedure

Secondary Outcomes (5)

• Oxygen partial pressure (PaO2)

  Baseline and within 15 minutes after completion of the endobronchial Ultrasound-Transbronchial Needle Aspiration (EBUS-TBNA) procedure

• Carbon dioxide partial pressure (PvCO2)

  Baseline and within 15 minutes after completion of the EBUS-TBNA

• Venous pH

  Baseline and within 15 minutes after completion of the EBUS-TBNA procedure.

• Venous Oxygen Saturation (SvO2)

  Baseline and within 15 minutes after completion of the EBUS-TBNA procedure.

• Recovry Time

  Up to 2 hours post-procedure

Study Arms (2)

Group H (High-Flow Nasal Oxygen Group)

Patients undergoing sedated EBUS-TBNA who receive high-flow nasal oxygen therapy during the procedure. Respiratory complications, oxygenation parameters, blood gas values, and post-procedural recovery outcomes are evaluated.

Device: High-Flow Nasal Oxygen Therapy

Group C (Conventional Oxygen Group)

Patients undergoing sedated EBUS-TBNA who receive conventional oxygen therapy during the procedure. Respiratory complications, oxygenation parameters, blood gas values, and post-procedural recovery outcomes are evaluated.

Device: Conventional Oxygen Therapy

Interventions

High-Flow Nasal Oxygen Therapy DEVICE

High-flow nasal oxygen therapy administered during sedated EBUS-TBNA procedures to provide enhanced oxygenation and respiratory support.

Group H (High-Flow Nasal Oxygen Group)

Conventional Oxygen Therapy DEVICE

Conventional oxygen therapy administered during sedated EBUS-TBNA procedures using standard oxygen delivery methods

Group C (Conventional Oxygen Group)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (≥18 years) scheduled to undergo sedated endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) at Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital. Participants will be allocated to receive either high-flow nasal oxygen therapy or conventional oxygen therapy during the procedure

You may qualify if:

• Age ≥18 years. Scheduled to undergo sedated EBUS-TBNA. Ability to provide written informed consent. ASA physical status I-III.

You may not qualify if:

• Age \<18 years.
• Pregnancy.
• Requirement for endotracheal intubation or general anesthesia.
• Severe hemodynamic instability.
• Refusal to participate in the study.
• Contraindication to high-flow nasal oxygen therapy.

Sponsors & Collaborators

• Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital: lead

Study Sites (1)

Ankara Dr. Abdurrahman Yurtaslan Oncolgy Training and Research Hospital

Ankara, Central, 0620, Turkey (Türkiye)

Location

Related Publications (1)

• Sampsonas F, Karamouzos V, Karampitsakos T, Papaioannou O, Katsaras M, Lagadinou M, Zarkadi E, Malakounidou E, Velissaris D, Stratakos G, Tzouvelekis A. High-Flow vs. Low-Flow Nasal Cannula in Reducing Hypoxemic Events During Bronchoscopic Procedures: A Systematic Review and Meta-Analysis. Front Med (Lausanne). 2022 Feb 24;9:815799. doi: 10.3389/fmed.2022.815799. eCollection 2022.

  PMID: 35280891 BACKGROUND

Central Study Contacts

ÖZLEM KAPUSUZ KÖRDUMAN, MD

CONTACT

+905058002027; zlmkpsz@hotmail.com

Güldeniz Argun, Prof

CONTACT

05336230405; guldargun@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiology and Reanimation Specialist

Study Record Dates

• First Submitted: August 5, 2026
• First Posted: August 12, 2026
• Study Start (Estimated): August 20, 2026
• Primary Completion (Estimated): October 20, 2026
• Study Completion (Estimated): November 20, 2026
• Last Updated: August 12, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)