Virtual Reality Versus Intradialytic Neuromuscular Electrical Stimulation on Renin Hormone in Chronic Kidney Patients

NCT07760285 | Completed DMC

• 1 other identifier: HSH000707
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Worldwide accelerated advances in physical rehabilitation of chronic kidney disease; particularly whom undergoing hemodialysis. Multimodal therapeutic approaches may maximize their recovery through preliminary evidence indicating both intradialytic neuromuscular electrical stimulation or Virtual reality-based rehabilitation (VRBR) is a relatively new method that might make it easier to simulate doing functional tasks than conventional rehabilitation.

Conditions

Chronic Kidney Disease (Stages 3b-5); Hemodialysis; Shoulder Adhesive Capsulitis

Keywords

Digital goniometer; shoulder dysfunction; shoulder pain and disability index; Virtual reality; Chronic kidney disease; Dynamometer; Renin Hormone; Intradialytic neuromuscular electrical stimulation; Maitland Mobilization

Outcome Measures

Primary Outcomes (1)

• Renin Hormone test

  SIEMENS, Blood Analyzer, Model: DCA Vantage, MPN: 4.6.0.0, USA; Hemostasis system equipment is manufactured by Siemens manumitted company, Germany for both renin hormone test and glomerular filtration rate monitoring among CKD patients collected samples early morning by responsible nursing staff from renal vein through the already inserted catheter/ or directly from patients' veins

  At pretreatment At post treatment after 8 weeks of the study protocol

Secondary Outcomes (3)

• Shoulder Range of Motion

  At pretreatment At posttreatment after 8 weeks of the study protocol

• Shoulder muscular strength

  At pretreatment At posttreatment after 8 weeks of study protocol

• The shoulder pain intensity and functional disability assessment

  At pretreatment At posttreatment of 8 weeks of the study protocol

Study Arms (3)

Experimental Group A (Virtual reality)

EXPERIMENTAL

20 participants suffering from CKD received Virtual reality by Xbox Kinect 360 console, plus conventional physical therapy protocol, along 8 weeks

Other: Virtual Reality session; Other: Conventional Physical Therapy protocol

Experimental Group B (intradialytic neuromuscular electrical stimulation )

EXPERIMENTAL

20 participants suffering from CKD received intradialytic neuromuscular electrical stimulation protocol, for 30 minutes, 3 times per week over 8 weeks.

Other: intradialytic neuromuscular electrical stimulation; Other: Conventional Physical Therapy protocol

Experimental Group A (conventional physical therapy protocol including Maitland mobilization)

EXPERIMENTAL

20 participants suffering from CKD received Maitland mobilization, plus Conventional physical therapy protocol, along 30-40 minutes, 3 sets/ week over 8 weeks.

Other: Maitland Mobilization; Other: Conventional Physical Therapy protocol

Interventions

Virtual Reality session OTHER

virtual reality exercise programs that was applied in form of a series of kinect adventure games and designed for Xbox 360 kinect console, and projected onto a 24-inch screen LED-Lit monitor; along 30-40 min, 3 sets/ week along 8 weeks

Experimental Group A (Virtual reality)

intradialytic neuromuscular electrical stimulation OTHER

The portable Chattanooga electric stimulation device has been switched on and adjusted the current amplitude/ strength from 5-140 mA according to each patients' targeted strength, frequency seated at 5Hz over shoulder musculatures under direct supervision along 30 minutes for each session, 3 sessions per week over 8 weeks

Experimental Group B (intradialytic neuromuscular electrical stimulation )

Maitland Mobilization OTHER

maitland graded oscillation technique that was applied to the glenohumeral (GH) joint in form of anteroposterior (A-P), posteroanterior (P-A), and longitudinal caudal glides; as well regarding sternoclavicular joint 'Posterior and anterior glide', plus acromioclavicular joint; anterior glide, only fifteen glides, along 30-40 min, 3 sets/ week along 8 weeks

Experimental Group A (conventional physical therapy protocol including Maitland mobilization)

Conventional Physical Therapy protocol OTHER

Active range of motion exercises; along 30-40 min, 3 sets/ week along 8 weeks

Experimental Group A (Virtual reality); Experimental Group A (conventional physical therapy protocol including Maitland mobilization); Experimental Group B (intradialytic neuromuscular electrical stimulation )

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patient underwent modified radical mastectomy from one month earlier, suffering from shoulder pain and limited range of motion were included in current study.
• Patients' age ranged from 40 to 65 years. Patients of both genders. All patients were free of any comorbidities such as systemic or neurological diseases.

You may not qualify if:

• Patient underwent modified radical mastectomy from one month earlier, suffering from shoulder pain and limited range of motion were included in current study.
• Patients' age ranged from 40 to 65 years. Patients of both genders. All patients were free of any comorbidities such as systemic or neurological diseases.

Sponsors & Collaborators

• Adly A Adam: lead

Study Sites (1)

Shebin ElKom Teaching Hospital

Cairo, Menofyia, 11432, Egypt

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Bursitis; Shoulder Pain

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Joint Diseases; Musculoskeletal Diseases; Arthralgia; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Randomized conducted via computerized 'version 25; SPSS Inc., Chicago, Illinois, USA". Each had 1 defining record to assign him/ her into triple equal groups, later were indexing cards in opaque envelopes. Thus,
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Physical Therapy Specialist

Model Details: Prospective, randomized, controlled trial

Study Record Dates

• First Submitted: August 7, 2026
• First Posted: August 12, 2026
• Study Start: January 1, 2026
• Primary Completion: July 1, 2026
• Study Completion: August 1, 2026
• Last Updated: August 12, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)