Bridging Economics and Public Trust: A Study of Dengue Vaccine Cost-effectiveness and Acceptance in Thais Visiting Hospital

NCT07759596 | Active Not Recruiting

• 1 other identifier: MU-MOU TMEC 25-918
• Study Type: observational
• Target: 350
• Locations: 1 country
• Sites: 1

Brief Summary

Study 1: Cost-effectiveness of TAK-003 Dengue Vaccination in Thailand This study aims to evaluate the cost-effectiveness of introducing the live-attenuated tetravalent dengue vaccine (TAK-003) into Thailand's national immunization program. The study will compare routine vaccination strategies targeting two high-risk age groups: older children aged 9-14 years and adolescents/young adults aged 15-24 years, to identify the most appropriate target population for national implementation. A model-based economic evaluation will be conducted using a static Markov model combined with a decision tree from a societal perspective. Model parameters will be obtained from published literature, national surveillance databases, healthcare utilization data, and other relevant sources. The model will estimate lifetime health outcomes, healthcare costs, quality-adjusted life years (QALYs), incremental cost-effectiveness ratios (ICERs), and budget impact. Deterministic and probabilistic sensitivity analyses will be performed to assess uncertainty in model parameters. The findings are expected to provide evidence to support policy decisions regarding the inclusion of TAK-003 in Thailand's national immunization program. Study 2: Determinants of Dengue Vaccine Acceptance among Thai Adults and Parents This study aims to examine dengue vaccine acceptance and factors influencing vaccination decisions among Thai adults and parents of children aged 4-18 years. Understanding vaccine acceptance is essential for successful implementation of future dengue vaccination programs in Thailand. This study will employ a sequential explanatory mixed-methods design consisting of two phases. The first phase is a cross-sectional survey conducted among Thai adults and parents attending outpatient clinics at two tertiary hospitals. Participants will complete a structured questionnaire assessing sociodemographic characteristics, dengue-related experiences, psychological antecedents of vaccination using a modified Thai version of the 7Cs model, willingness to pay, and dengue vaccine acceptance. In the second phase, purposively selected participants from the quantitative survey will participate in semi-structured in-depth interviews to explore perceptions, beliefs, attitudes, and contextual factors influencing dengue vaccine decision-making. Quantitative and qualitative findings will be integrated to provide a comprehensive understanding of vaccine acceptance and hesitancy. The findings will provide evidence to inform communication strategies, public health interventions, and policy development aimed at improving dengue vaccine uptake in Thailand.

Conditions

Dengue Fever

Keywords

economic burden; vaccine acceptance; dengue vaccine; cost-effectiveness

Outcome Measures

Primary Outcomes (1)

• Dengue vaccine hesitancy measured using the 7C-model

  Dengue vaccine hesitancy will be assessed using an adapted version of the validated 7C Model of Vaccine Readiness questionnaire. The questionnaire will be adapted to the context of dengue vaccination while retaining the seven psychological antecedents of vaccination: Confidence, Complacency, Constraints, Calculation, Collective Responsibility, Compliance, and Conspiracy.

  1 year

Study Arms (1)

Objective 1- economic evaluation of Thai children without dengue vaccine

Children age 9-14 and 15-24 years without dengue vaccine

Other: Objective 1- economic evaluation of Thai children with dengue vaccine

Interventions

Objective 1- economic evaluation of Thai children with dengue vaccine OTHER

Thai children age 9-14 and 15-24 years with dengue vaccine

Objective 1- economic evaluation of Thai children without dengue vaccine

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

General population Inclusion criteria - Visiting hospitals for routine follow up their medical conditions at Med OPD, Hospital for Tropical Diseases Mahidol University. Parents Inclusion criteria \- Visiting hospitals for their children's routine follow up appointment at children OPD Siriraj Hospital, Mahidol University

You may qualify if:

• Both males and females Thai
• Adults aged 18 years and older
• Willing to participate in the study
• Never received dengue vaccine
• either single or married status without legitimate children
• having independent sources of incomes.

You may not qualify if:

• All types of Health care personnel
• visiting hospital due to clinical suspicions or confirmation of dengue infection
• Have no prior knowledge or awareness of dengue or dengue vaccines.
• Parents
• Both males and females Thai
• Adults aged 18 years and older
• Willing to participate in the study
• Having legitimate children aged 4 to 18 years old with dengue vaccine naïve
• Having independent sources of income.
• All types of Health care personnel
• Visiting hospital due to their children's illnesses such as clinical suspicions or confirmation of dengue infection.
• Have no prior knowledge or awareness of dengue or dengue vaccines.

Sponsors & Collaborators

• Mahidol University: lead
• Siriraj Hospital: collaborator

Study Sites (1)

Hospital for Tropical Diseases, Faculty of Tropical Medicine

Bangkok, Thailand

Location

MeSH Terms

Conditions

Dengue; Financial Stress

Interventions

Dengue Vaccines

Condition Hierarchy (Ancestors)

Mosquito-Borne Diseases; Vector Borne Diseases; Infections; Arbovirus Infections; Virus Diseases; Flavivirus Infections; Flaviviridae Infections; RNA Virus Infections; Hemorrhagic Fevers, Viral; Stress, Psychological; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Viral Vaccines; Vaccines; Biological Products; Complex Mixtures

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: February 23, 2026
• First Posted: August 12, 2026
• Study Start: February 2, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: August 12, 2026

Record last verified: 2026-08

Locations

TH (1)