Parasternal Intercostal Plane Catheter for Pain Control After CABG Surgery

NCT07759570 | Not Yet Recruiting

• 1 other identifier: 2026.216.IRB1.015
• Study Type: interventional
• Target: 56
• Locations: 1 country
• Sites: 1

Brief Summary

Coronary artery bypass graft (CABG) surgery performed via sternotomy (incision of the breastbone) can cause severe pain after surgery; this can slow recovery and increase the need for opioid pain relievers. This study investigates whether placing a catheter to deliver a local anesthetic to the superficial parasternal intercostal plane reduces pain following this type of heart surgery. Patients undergoing CABG via sternotomy will be randomly assigned to either the catheter-based analgesia group or the standard pain management group. The researchers will compare postoperative pain levels and analgesic medication requirements between the two groups to determine whether this technique improves postoperative pain control.

Conditions

Bypass Surgery; Arrythmia; Postoperative Pain

Keywords

parasternal block; postoperative analgesia; cardiovascular surgery; arrhythmia; regional anesthesia

Outcome Measures

Primary Outcomes (1)

• Cumulative opioid consumption at 24 hours post-operatively (mg morphine equivalent).

  Cumulative opioid consumption (patient controlled analgesia and rescue analgesia) at the first 24 hours postoperatively

  Postoperative 24 hours

Secondary Outcomes (14)

• Resting NRS pain scores at 12, 24, 36, 48, 60, and 72 hours post-Surgery

  at 12, 24, 36, 48, 60, and 72 hours post-Surgery

• NRS pain scores associated with coughing at 12, 24, 36, 48, 60, and 72 hours post-Surgery

  at 12, 24, 36, 48, 60, and 72 hours post-Surgery

• Total amount of opioids consumed during the first 72 hours after surgery

  at the first 72 hours after surgery

• Time to first rescue analgesic administration

  The patient will be monitored for the first 72 hours after surgery.

• Time to extubation (in minutes) following admission to the postoperative intensive care unit

  From intensive care unit admission until extubation, assessed up to 72 hours after intensive care unit admission

Study Arms (2)

Block group

ACTIVE COMPARATOR

Patiens receiving bilateral superficial parasternal catheter at the end of the surgery

Other: Parasternal blocks

Control group

NO INTERVENTION

No superficial parasternal catheter will be placed

Interventions

Parasternal blocks OTHER

Bilateral superficial parasternal block catheters will be placed at the end of the surgery, at the level of 3rd rib using ultrasound guidance

Block group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \- Adult patients with coronary artery disease scheduled for coronary artery bypass graft surgery

You may not qualify if:

• Under 18 years of age
• ASA (American Society of Anesthesiologists) Class V patients
• Non-elective emergency cases
• Patient refusal to participate in the study
• Language barrier
• Patients who have previously undergone sternotomy
• History of significant psychiatric disorders
• Patients with known long-term opioid use
• Patients with potential contraindications to nerve blocks (bleeding diathesis, infection, and allergy to local anesthetics)
• Patients with an ejection fraction \<40%
• Patients with right ventricular systolic dysfunction (patients with TAPSE \<1.8 cm)
• Patients with a left atrial diameter \>4 cm
• Patients with severe valvular heart disease
• Patients undergoing concomitant valvular heart surgery
• Patients with a history of atrial flutter and/or atrial fibrillation

Sponsors & Collaborators

• Koc University Hospital: lead

Study Sites (1)

Koc University Hospital

Istanbul, Zeytinburnu, 34010, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Arrhythmias, Cardiac; Pain, Postoperative

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Postoperative Complications; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Statistician
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Resident

Study Record Dates

• First Submitted: July 31, 2026
• First Posted: August 12, 2026
• Study Start (Estimated): August 30, 2026
• Primary Completion (Estimated): October 30, 2026
• Study Completion (Estimated): November 15, 2026
• Last Updated: August 12, 2026

Record last verified: 2026-08

Data Sharing

• IPD Sharing: Will share
• Time Frame: Starting at the completion of the study (anticipated November 2026) with no end date
• Access Criteria: Anonymized patient data will be open to be accessed by any researcher

Locations

TU (1)