Comparison of Alignment Speed, Patient Discomfort and Root Resorption Between Two Different Sequences of Archwires

NCT07758556 | Completed

• 1 other identifier: FUCDCLINIC-2403
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 3

Brief Summary

In this Clinical trial we aim to compare alignment speed, patient discomfort and root resorption between two different sequences of NiTi archwires

Conditions

Speed of Alignment, Pain, External Root Resorption

Outcome Measures

Primary Outcomes (1)

• Speed of alignment

  Speed of alignment will be calculated in terms of number of visits

  6 months

Secondary Outcomes (1)

• Patient discomfort

  6 months

Other Outcomes (1)

• Root resorption

  6 months

Study Arms (2)

Group A

EXPERIMENTAL

Patients undergoing archwire sequence as follows 0.014 inch NiTi 0.019x0.025 inch NiTi

Device: Archwire

Group B

EXPERIMENTAL

Patients undergoing archwire sequence as follows 0.014 inch NiTi 0.018 inch NiTi 0.020 inch NiTi 0.016x0.022 inch NiTi 0.019x0.025 inch NiTi

Device: Archwire

Interventions

Archwire DEVICE

NiTi Archwires will be used for tooth alignment

Group A; Group B

Eligibility Criteria

• Age: 12 Years - 35 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Age range 12-35 years.
• Both male and female patients.
• Medically-fit patients with no medical condition associated with root resorption risk.
• No previous history of orthodontic treatment.
• Patients requiring complete upper and lower orthodontic treatment with fixed appliance.
• Angle class I, II, and III malocclusion with crowding in both maxillary and mandibular anterior dentition.
• Healthy permanent dentition with adequate oral hygiene and no periodontal diseases; before the start of orthodontic treatment.

You may not qualify if:

• Cleft lip \& palate patients
• Syndromic patients
• Patients with bone pathologies
• Habits such as smoking
• Patients with parafunctional habits or history of pre-existing root resorption
• Patients taking drugs which inhibit or accelerate tooth movement
• Tooth or teeth with periapical infection.
• Patients with pain from any other medical or dental condition that may have affected their reported discomfort scores were excluded
• Endodontically treated mandibular or maxillary anterior teeth
• Presence of blocked-out tooth that did not allow for placement of the bracket or full AW engagement at the initial bonding.

Sponsors & Collaborators

• Foundation University Islamabad: lead

Study Sites (3)

Foundation University Islamabad

Islamabad, Punjab Province, 04403, Pakistan

Location

FUI

Islamabad, Punjab Province, 43000, Pakistan

Location

FUI

Islamabad, Punjab Province, 46000, Pakistan

Location

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Shoaib Rahim, FCPS

  FUCD & H

  STUDY CHAIR

• Rozina Nazir, FCPS

  FUCD & H

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants will have no idea which group of archwires they are included in
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 6, 2026
• First Posted: August 11, 2026
• Study Start: December 20, 2024
• Primary Completion: July 2, 2025
• Study Completion: September 2, 2025
• Last Updated: August 11, 2026

Record last verified: 2026-08

Locations

PA (3)