Stakeholder-Informed RSV Prevention Economic Model in Botswana

NCT07756528 | Active Not Recruiting

• 2 other identifiers: 814288318586-00001
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this mixed methods study is to engage stakeholders to develop a health economic model to estimate the costs, health benefits, and value of respiratory syncytial virus (RSV) prevention strategies. The model will help decision-makers in Botswana determine whether and how to introduce RSV prevention interventions for infants, including monoclonal antibodies. The main questions the study aims to answer are: How could RSV prevention strategies be delivered to infants in Botswana? What costs, health benefits, and implementation factors should be included in a health economic model? What information do policymakers, healthcare providers, funders, researchers, and other stakeholders need to make decisions about RSV prevention? Participants will include key stakeholders involved in health policy, clinical care, financing, research, and child health in Botswana. Participants may be asked to complete an interview, take part in a stakeholder workshop, complete a survey, and help review or interpret model findings. The study will not test an RSV product in infants or provide medical treatment.

Conditions

RSV

Keywords

Respiratory syncytial virus; RSV monoclonal antibody; Health economic model; Budget impact; Cost-effectiveness; Stakeholder engagement; Decision analysis

Outcome Measures

Primary Outcomes (1)

• Completion of a stakeholder-informed health economic model to evaluate RSV prevention strategies for infants in Botswana.

  Model completion will be measured as the number of pre-specified model development milestones completed. Milestones include: finalizing the model structure; identifying and documenting model input parameters; programming the model; conducting internal model checks; generating base-case results; conducting sensitivity analyses; reviewing model assumptions and preliminary results with stakeholders; and producing final model outputs for dissemination.

  July 1, 2026 to December 30, 2027

Secondary Outcomes (1)

• Stakeholder-rated quality of engagement

  July 1, 2026 to December 30, 2027

Study Arms (1)

Stakeholder group representing policymakers, healthcare providers, researchers, funders, an

Up to 40 stakeholders will participate in an interview and up to 20 will participate in a workshop on health economic modeling and a pre/post survey.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We will establish a 20-member stakeholder advisory board representing policymakers (n=5), funders (n=3), healthcare providers (n=5), researchers (n=2), and leaders representing patient groups (n=5).

You may qualify if:

• Expertise or Role:
• Policymakers: Currently employed in or recently retired from a government health agency, Ministry of Health, or other institution with responsibility for health policy, immunization, or maternal/child health.
• Funders: Employed by or affiliated with an organization that funds health services, immunization programs, or health research in Botswana or the region.
• Healthcare providers: Licensed clinicians (e.g., pediatricians, nurses, midwives) with direct experience delivering maternal or child health services in Botswana.
• Researchers: Active or recent experience in health economics, public health, or RSV-related research, with relevance to LMICs.
• Patient representatives: Affiliated with or leading a civil society or patient advocacy organization focused on child health, immunization, or health equity in Botswana.
• Geographic Relevance: Based in Botswana or with demonstrated experience working within Botswana's health system or policy landscape.
• Language: Comfortable speaking and reading English or Setswana.

Sponsors & Collaborators

• University of California, San Diego: lead
• Botswana Harvard AIDS Institute Partnership: collaborator

Study Sites (1)

Botswana Harvard Health Partnership

Gaborone, Gaborone, Botswana

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: August 6, 2026
• First Posted: August 10, 2026
• Study Start: July 1, 2026
• Primary Completion (Estimated): October 1, 2027
• Study Completion (Estimated): December 30, 2027
• Last Updated: August 10, 2026

Record last verified: 2026-07

Data Sharing

• IPD Sharing: Will not share

Locations

BO (1)